Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.5.1.52 extracted from

  • MIsaghi, S.; Korbel, G.A.; Kessler, B.; Spooner, E.; Ploegh, H.L.
    Z-VAD-fmk inhibits peptide:N-glycanase and may result in ER stress (2006), Cell Death Differ., 13, 163-165.
    View publication on PubMed
Search for more literature for 3.5.1.52

Inhibitors

Inhibitors Comment Organism Structure
additional information the enzyme is preferably inhibited by aspartate-based inhibitors Saccharomyces cerevisiae
Z-VAD-fmk i.e. carbobenzyloxy-Val-Ala-Asp-alpha-fluoromethylketone, a broad-spectrum caspase inhibitor, potent inhibition, binding structure determination and analysis with wild-type and mutant C191A enzyme, the inhibitor binds covalently to the catalytic residue Cys191, but not to the catalytic His218 Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Reaction

Reaction Comment Organism Reaction ID
Manalpha(1-6)(Xylbeta(1-2))Manbeta(1-4)GlcNAcbeta(1-4)(Fucalpha(1-3))GlcNAc-Asn-Asp-Glu-Ser-Ser + H2O = Manalpha(1-6)(Xylbeta(1-2))Manbeta(1-4)GlcNAcbeta(1-4)(Fucalpha(1-3))GlcNAc + Asn-Asp-Glu-Ser-Ser the catalytic triad is formed by Cys191, His218, and Asp235 Saccharomyces cerevisiae
a

Synonyms

Synonyms Comment Organism
peptide:N-glycanase
-
 Saccharomyces cerevisiae
YPng1
-
 Saccharomyces cerevisiae