Cloned (Comment) | Organism |
---|---|
cloning of Acy1 from a mouse kidney library, expression of the C-terminal fragment in HEK-293 cells, in vitro expression of the GST-tagged C-terminal fragment, expression as myc-tagged enzyme in Cos-7 cells, expression with murine sphingosine kinase type 1, SphK1, in a yeast two-hybrid system | Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | metalloenzyme | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | the enzyme is involved in the regulation of oxidative stress, and, by direct interaction, of sphingosine kinase type 1, SphK1, which has a role in cell growth promotion and inhibition of tumor cell apoptosis, Acy1 induces redistribution of SphK1 to the plasma membrane from cytosol, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant GST-tagged C-terminal fragment from an in vitro expression system by glutathione affinity chromatography | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme is involved in the regulation of oxidative stress, and, by direct interaction, of sphingosine kinase type 1, SphK1, which has a role in cell growth promotion and inhibition of tumor cell apoptosis, Acy1 induces redistribution of SphK1 to the plasma membrane from cytosol, overview | Mus musculus | ? | - |
? | |
additional information | the enzyme interacts with sphingosine kinase type 1, SphK1 | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Acy1 | - |
Mus musculus |
aminoacylase 1 | - |
Mus musculus |
sphingosine kinase 1-interacting protein | - |
Mus musculus |