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Information on EC 3.5.1.14 - N-acyl-aliphatic-L-amino acid amidohydrolase

for references in articles please use BRENDA:EC3.5.1.14
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IUBMB Comments
Contains Zn2+. The enzyme is found in animals and is involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). It acts on mercapturic acids (S-conjugates of N-acetyl-L-cysteine) and neutral aliphatic N-acyl-alpha-amino acids. Some bacterial aminoacylases demonstrate substrate specificity of both EC 3.5.1.14 and EC 3.5.1.114. cf. EC 3.5.1.15, aspartoacylase and EC 3.5.1.114, N-acyl-aromatic-L-amino acid amidohydrolase.
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Word Map
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
aminoacylase, acylase i, aminoacylase i, aminoacylase 1, aminoacylase-1, l-aminoacylase, aaiii, porcine kidney aminoacylase, pacy1, phoacy, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
an N-acetyl-L-cysteine-S-conjugate + H2O = an L-cysteine-S-conjugate + acetate
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(2)
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an N-acyl-aliphatic-L-amino acid + H2O = an aliphatic L-amino acid + a carboxylate
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