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Literature summary for 3.5.1.105 extracted from

  • Kim, E.J.; Park, M.K.; Byun, H.J.; Kang, G.J.; Yu, L.; Kim, H.J.; Shim, J.G.; Lee, H.; Lee, C.H.
    YdjC chitooligosaccharide deacetylase homolog induces keratin reorganization in lung cancer cells involvement of interaction between YDJC and CDC16 (2018), Oncotarget, 9, 22915-22928 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.1.105

Application

Application Comment Organism
diagnostics the overall survival is high in lung cancer patients having low expression level of YDJC, while progression free survival is decreased in patients having high expression level of YDJC Homo sapiens

Protein Variants

Protein Variants Comment Organism
D13A site-directed mutagenesis, the enzyme mutant lost its activity to induce sphingosylphosphorylcholine (SPC)-induced phosphorylation and reorganization of keratin 8. Overexpression of YDJCD13A cannot induce K8 phosphorylation, and YDJCD13A overexpression suppresses SPC-induced migration and invasion of A549 lung cancer cells. For gene silencing of YDJC, the A-549, H-1703, and H-23 cells are transfected with YDJC siRNA or control siRNA and stimulated with or without SPC Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
CDC16 binds to the enzyme and inhibits sphingosylphosphorylcholine (SPC)-induced phosphorylation and reorganization of keratin 8 (K8) induced by YdjC Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens YDJC binds to CDC16 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens A8MPS7
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
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lung
-
 Homo sapiens
-
lung cancer cell YDJC expression is increased in patient lung adenocarcinoma Homo sapiens
-
NCI-H1703 cell
-
 Homo sapiens
-
NCI-H23 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information YDJC binds to CDC16 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
chitooligosaccharide deacetylase homolog
-
 Homo sapiens
YdjC
-
 Homo sapiens
YDJC deacetylase
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens sphingosylphosphorylcholine induced expression of YDJC in a dose- and time-dependent manner up

General Information

General Information Comment Organism
evolution YDJC belongs to the YDJC superfamily and exerts deacetylase activity Homo sapiens
malfunction gene silencing of YDJC suppresses sphingosylphosphorylcholine (SPC)-induced events. YdjC overexpression induces the SPC-induced events. YdjC deacetylase dominant negative mutant (YDJCD13A) does not induce SPC-induced events. YDJC siRNA reduces ERK activation and overexpression of YDJC induces ERK activation. The siRNA of ERK1 or ERK2 suppresses YDJC-induced phosphorylation and reorganization of keratin 8 (K8), and migration and invasion Homo sapiens
metabolism involvement of the deacetylase activity of YDJC in keratin reorganization Homo sapiens
physiological function role and molecular mechanisms of YdjC chitooligosaccharide deacetylase homologue YDJC in sphingosylphosphorylcholine (SPC)-induced phosphorylation and reorganization of keratin 8 (K8), and migration and invasion (SPC-induced events), overview Homo sapiens