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Literature summary for 3.5.1.104 extracted from
- Polysaccharide deacetylases serve as new targets for the design of inhibitors against Bacillus anthracis and Bacillus cereus (2018), Bioorg. Med. Chem., 26, 3845-3851 .
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| crystal structure analysis of Zn-bound enzyme | Bacillus cereus |
| crystal structure analysis of Zn-bound enzyme | Bacillus anthracis |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | construction of Bacillus anthracis 7702 DELTAba1977 mutant strain | Bacillus anthracis |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-naphthoxyhydroxamic acid | - |
Bacillus anthracis |  |
| 1-naphthoxyhydroxamic acid | - |
Bacillus cereus | |
| 3-biphenylhydroxamic acid | - |
Bacillus anthracis | |
| 3-biphenylhydroxamic acid | - |
Bacillus cereus | |
| N-hydroxy-3-phenoxybenzamide | - |
Bacillus anthracis | |
| N-hydroxy-3-phenoxybenzamide | - |
Bacillus cereus | |
| N-hydroxy-4-(naphthalene-1-yl)benzamide | - |
Bacillus anthracis | |
| N-hydroxy-4-(naphthalene-1-yl)benzamide | a potent competitive inhibitor; a potent competitive inhibitor | Bacillus cereus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0048 | - |
(GlcNAc)5 | pH 6.8, 22°C | Bacillus cereus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | a zinc metalloenzyme | Bacillus cereus | |
| Zn2+ | a zinc metalloenzyme | Bacillus anthracis | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacillus anthracis | A0A2B6CE99 | - |
- |
| Bacillus anthracis | A0A2P0HD08 | - |
- |
| Bacillus cereus | Q81EJ6 | - |
- |
| Bacillus cereus | Q81EK9 | - |
- |
| Bacillus cereus ATCC 14579 | Q81EJ6 | - |
- |
| Bacillus cereus ATCC 14579 | Q81EK9 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (GlcNAc)5 + H2O | - |
Bacillus cereus | ? | - |
? | |
| (GlcNAc)5 + H2O | - |
Bacillus cereus ATCC 14579 | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| BA1961 | - |
Bacillus anthracis |
| BA1977 | - |
Bacillus anthracis |
| BC1960 | - |
Bacillus cereus |
| Bc1974 | - |
Bacillus cereus |
| BC_1960 | - |
Bacillus cereus |
| BC_1974 | - |
Bacillus cereus |
| peptidoglycan GlcNAc deacetylases | - |
Bacillus cereus |
| peptidoglycan GlcNAc deacetylases | - |
Bacillus anthracis |
| peptidoglycan N-acetylglucosamine deacetylase | - |
Bacillus cereus |
| peptidoglycan N-acetylglucosamine deacetylase | - |
Bacillus anthracis |
| pgdA_1 | - |
Bacillus anthracis |
| pgdA_2 | - |
Bacillus anthracis |
| PGNGdacs | - |
Bacillus cereus |
| PGNGdacs | - |
Bacillus anthracis |
| polysaccharide deacetylase | - |
Bacillus cereus |
| polysaccharide deacetylase | - |
Bacillus anthracis |
| yheN | - |
Bacillus anthracis |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 22 | - |
assay at room temperature | Bacillus cereus |
| 37 | - |
assay at | Bacillus anthracis |
| 50 | - |
- |
Bacillus cereus |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 3000 | - |
(GlcNAc)5 | pH 6.8, 22°C | Bacillus cereus | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6 | - |
- |
Bacillus cereus |
| 6.8 | - |
- |
Bacillus cereus |
| 7.3 | - |
assay at | Bacillus anthracis |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | inhibition kinetic analysis | Bacillus cereus | |
| additional information | - |
additional information | inhibition kinetic analysis | Bacillus anthracis | |
| 0.0087 | - |
N-hydroxy-4-(naphthalene-1-yl)benzamide | pH 6.8, 22°C | Bacillus cereus | |
| 0.066 | - |
N-hydroxy-4-(naphthalene-1-yl)benzamide | pH 6.0, 50°C | Bacillus cereus | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0433 | - |
pH 6.8, 22°C | Bacillus cereus | N-hydroxy-4-(naphthalene-1-yl)benzamide | |
| 0.132 | - |
pH 6.0, 50°C | Bacillus cereus | N-hydroxy-4-(naphthalene-1-yl)benzamide | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| additional information | sequence comparisons of the PGNGdacs BC1960, BA1961, BC1974 and BA1977 from Bacillus cereus and Bacillus anthracis | Bacillus cereus |
| additional information | sequence comparisons of the PGNGdacs BC1960, BA1961, BC1974 and BA1977 from Bacillus cereus and Bacillus anthracis | Bacillus anthracis |
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