BRENDA - Enzyme Database
show all sequences of 3.4.24.84

The Arabidopsis AtSTE24 is a CAAX protease with broad substrate specificity

Bracha, K.; Lavy, M.; Yalovsky, S.; J. Biol. Chem. 277, 29856-29864 (2002)

Data extracted from this reference:

Cloned(Commentary)
Cloned (Commentary)
Organism
expression of AtSte24 in Sacchromyces cerevisiae ste24DELTA mutant
Arabidopsis thaliana
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
endoplasmic reticulum
-
Arabidopsis thaliana
5783
-
integral to membrane
hydropathy blot analysis suggests 7 membrane-spanning domains
Arabidopsis thaliana
-
-
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
additional information
zinc metalloprotease motif HEXXH
Arabidopsis thaliana
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
48455
-
x * 48455, deduced from nucleotide sequence
Arabidopsis thaliana
Organism
Organism
UniProt
Commentary
Textmining
Arabidopsis thaliana
Q8RX88
-
-
Homo sapiens
O75844
-
-
Saccharomyces cerevisiae
P47154
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
flower
-
Arabidopsis thaliana
-
leaf
-
Arabidopsis thaliana
-
stem
-
Arabidopsis thaliana
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
a-factor + H2O
-
638978
Arabidopsis thaliana
fragments of a-factor
-
638978
Arabidopsis thaliana
?
CaM53 + H2O
CaM53 is a prenylated C2+-calmodulin from petunia
638978
Arabidopsis thaliana
fragments of CaM53
-
638978
Arabidopsis thaliana
?
RACU88402 + H2O
RACU88402 is a Rac-like GTPase
638978
Arabidopsis thaliana
fragments of RACU88402
-
638978
Arabidopsis thaliana
?
Subunits
Subunits
Commentary
Organism
?
x * 48455, deduced from nucleotide sequence
Arabidopsis thaliana
Synonyms
Synonyms
Commentary
Organism
AtSte24
-
Arabidopsis thaliana
Cloned(Commentary) (protein specific)
Commentary
Organism
expression of AtSte24 in Sacchromyces cerevisiae ste24DELTA mutant
Arabidopsis thaliana
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
endoplasmic reticulum
-
Arabidopsis thaliana
5783
-
integral to membrane
hydropathy blot analysis suggests 7 membrane-spanning domains
Arabidopsis thaliana
-
-
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
additional information
zinc metalloprotease motif HEXXH
Arabidopsis thaliana
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
48455
-
x * 48455, deduced from nucleotide sequence
Arabidopsis thaliana
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
flower
-
Arabidopsis thaliana
-
leaf
-
Arabidopsis thaliana
-
stem
-
Arabidopsis thaliana
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
a-factor + H2O
-
638978
Arabidopsis thaliana
fragments of a-factor
-
638978
Arabidopsis thaliana
?
CaM53 + H2O
CaM53 is a prenylated C2+-calmodulin from petunia
638978
Arabidopsis thaliana
fragments of CaM53
-
638978
Arabidopsis thaliana
?
RACU88402 + H2O
RACU88402 is a Rac-like GTPase
638978
Arabidopsis thaliana
fragments of RACU88402
-
638978
Arabidopsis thaliana
?
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 48455, deduced from nucleotide sequence
Arabidopsis thaliana
Other publictions for EC 3.4.24.84
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
753395
Spear
ZMPSTE24 missense mutations t ...
Homo sapiens
Dis. Model. Mech.
11
dmm033670
2018
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15
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1
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15
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3
-
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-
-
-
-
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-
2
2
-
-
-
755334
Clark
Human CaaX protease ZMPSTE24 ...
Homo sapiens
Protein Sci.
26
242-257
2017
-
-
1
1
1
-
5
-
-
1
-
3
-
4
-
-
1
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-
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4
-
1
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5
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1
-
1
1
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5
5
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1
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3
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1
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-
4
-
-
-
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-
-
-
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-
754136
Hildebrandt
Ste24p mediates proteolysis o ...
Saccharomyces mikatae
J. Biol. Chem.
291
14185-14198
2016
-
-
-
-
-
-
-
6
-
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2
-
2
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12
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1
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6
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2
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-
12
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
719313
Ahmad
Homozygous null mutations in Z ...
Homo sapiens
Clin. Genet.
81
158-164
2012
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
-
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1
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3
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-
-
-
-
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-
-
-
-
-
735044
Barrowman
Requirements for efficient pro ...
Homo sapiens
PLoS ONE
7
e32120
2012
-
1
1
-
9
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
1
-
2
-
2
-
-
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-
-
-
-
-
-
-
-
-
1
1
-
-
9
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
710803
Smigiel
Novel frameshifting mutations ...
Homo sapiens
Am. J. Med. Genet. A
152A
447-452
2010
-
1
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
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1
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1
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-
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-
-
-
-
-
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-
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-
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-
-
-
718809
Goulbourne
HIV protease inhibitors inhibi ...
Homo sapiens
Biochem. Soc. Trans.
38
292-296
2010
-
-
-
-
-
-
1
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
1
-
1
-
-
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-
-
-
-
-
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-
-
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-
-
-
-
-
-
1
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-
-
-
-
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-
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-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
712629
Rivas
Accelerated features of age-re ...
Mus musculus
J. Gerontol. A Biol. Sci. Med. Sci.
64
1015-1024
2009
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
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-
1
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-
1
-
-
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-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
678447
Porter
Inhibition of the CaaX proteas ...
Arabidopsis thaliana, Homo sapiens, Saccharomyces cerevisiae
Biochim. Biophys. Acta
1773
853-862
2007
-
-
-
-
-
-
6
-
-
-
-
-
-
3
-
-
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-
3
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6
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
682549
Coffinier
HIV protease inhibitors block ...
Mus musculus
Proc. Natl. Acad. Sci. USA
104
13432-13437
2007
-
-
-
-
-
-
2
-
-
-
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4
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1
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2
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2
2
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-
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-
-
-
-
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-
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-
-
667497
Corrigan
Prelamin A endoproteolytic pro ...
Homo sapiens
Biochem. J.
387
129-138
2005
-
-
1
-
1
-
2
-
3
1
1
-
-
2
-
-
1
-
-
-
-
-
3
-
1
-
-
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-
-
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-
1
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-
1
-
-
2
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3
1
1
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-
1
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
669751
Moulson
Homozygous and compound hetero ...
Homo sapiens
J. Invest. Dermatol.
125
913-919
2005
-
1
-
-
-
-
-
-
-
-
-
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2
-
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-
2
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2
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1
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2
-
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-
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-
-
670378
Varela
Accelerated ageing in mice def ...
Mus musculus
Nature
437
564-568
2005
-
1
-
-
1
-
-
-
-
-
-
-
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3
-
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-
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4
-
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2
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1
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1
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4
-
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-
638978
Bracha
The Arabidopsis AtSTE24 is a C ...
Arabidopsis thaliana, Homo sapiens, Saccharomyces cerevisiae
J. Biol. Chem.
277
29856-29864
2002
-
-
1
-
-
-
-
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2
1
1
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9
-
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3
-
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3
1
1
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1
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2
1
1
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3
-
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3
1
-
-
-
-
-
-
-
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638977
Tam
The multispanning membrane pro ...
Saccharomyces cerevisiae
J. Biol. Chem.
276
46798-46806
2001
-
-
-
-
-
-
1
-
2
2
-
-
-
2
-
-
1
-
-
-
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1
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1
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2
2
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1
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1
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-
652151
Leung
Biochemical studies of Zmpste2 ...
Mus musculus
J. Biol. Chem.
276
29051-29058
2001
-
-
1
-
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-
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-
1
-
-
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4
-
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2
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1
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1
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1
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2
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654005
Pei
Type II CAAX prenyl endopeptid ...
Saccharomyces cerevisiae
Trends Biochem. Sci.
26
275-277
2001
-
-
-
-
-
-
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-
1
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1
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2
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1
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638976
Schmidt
Reconstitution of the Ste24p-d ...
Homo sapiens, Saccharomyces cerevisiae
J. Biol. Chem.
275
6227-6233
2000
-
-
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1
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2
3
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4
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4
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4
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653214
Trueblood
The CaaX proteases, Afc1p and ...
Saccharomyces cerevisiae
Mol. Cell. Biol.
20
4381-4392
2000
-
-
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1
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2
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2
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1
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2
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638974
Tam
Dual roles for Ste24p in yeast ...
Homo sapiens, Saccharomyces cerevisiae
J. Cell Biol.
142
635-649
1998
-
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1
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2
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1
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4
-
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4
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1
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1
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2
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1
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4
-
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638975
Schmidt
Endoplasmic reticulum membrane ...
Saccharomyces cerevisiae
Proc. Natl. Acad. Sci. USA
95
11175-11180
1998
-
-
-
-
-
-
-
-
3
-
-
-
-
2
-
-
-
-
-
1
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3
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1
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651423
Boyartchuk
Roles pf prenyl protein protea ...
Saccharomyces cerevisiae
Genetics
150
95-1001
1998
-
-
-
-
-
-
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1
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3
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2
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1
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2
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638973
Fujimura-Kamada
A novel membrane-associated me ...
Saccharomyces cerevisiae
J. Cell Biol.
136
271-285
1997
-
-
1
-
3
-
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1
1
1
1
-
6
-
-
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-
-
-
-
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2
1
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1
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653884
Boyartchuk.V.L.; Ashby
Modulation of Ras and a-factor ...
Saccharomyces cerevisiae
Science
275
1796-1800
1997
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