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Literature summary for 3.4.24.83 extracted from

  • Maize, K.M.; Kurbanov, E.K.; Johnson, R.L.; Amin, E.A.; Finzel, B.C.
    Ligand-induced expansion of the S1 site in the anthrax toxin lethal factor (2015), FEBS Lett., 589, 3836-3841 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.83

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Rosetta2 pLysS cells Bacillus anthracis

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drop vapor diffusion method Bacillus anthracis

Inhibitors

Inhibitors Comment Organism Structure
(2R)-2-[(4-fluoro-3-methoxybenzene-1-sulfonyl)(2-methylpropyl)amino]-N-hydroxy-3-methylbutanamide
-
 Bacillus anthracis
(2R)-2-[(4-fluoro-3-methylbenzene-1-sulfonyl)(2-methylpropyl)amino]-N-hydroxy-3-methylbutanamide
-
 Bacillus anthracis
(2R)-2-[(4-fluoro-3-methylbenzene-1-sulfonyl)amino]-N-hydroxy-2-(oxan-4-yl)acetamide
-
 Bacillus anthracis
(2R)-2-[(4-fluoro-3-methylbenzene-1-sulfonyl)[(4-nitrophenyl)methyl]amino]-N-hydroxypropanamide
-
 Bacillus anthracis
N-hydroxy-N2-[[3-(methoxymethyl)phenyl]sulfonyl]-N2-(2-methylpropyl)-D-valinamide
-
 Bacillus anthracis

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ contains zinc Bacillus anthracis

Organism

Organism UniProt Comment Textmining
Bacillus anthracis P15917
-
-

Purification (Commentary)

Purification (Comment) Organism
nickel affinity column chromatography and Superdex S200 gel filtration Bacillus anthracis

Synonyms

Synonyms Comment Organism
anthrax toxin lethal factor
-
 Bacillus anthracis

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0001
-
 pH and temperature not specified in the publication Bacillus anthracis (2R)-2-[(4-fluoro-3-methylbenzene-1-sulfonyl)amino]-N-hydroxy-2-(oxan-4-yl)acetamide
0.0149
-
 pH and temperature not specified in the publication Bacillus anthracis (2R)-2-[(4-fluoro-3-methylbenzene-1-sulfonyl)[(4-nitrophenyl)methyl]amino]-N-hydroxypropanamide
0.09
-
 pH and temperature not specified in the publication Bacillus anthracis (2R)-2-[(4-fluoro-3-methylbenzene-1-sulfonyl)(2-methylpropyl)amino]-N-hydroxy-3-methylbutanamide
0.267
-
 pH and temperature not specified in the publication Bacillus anthracis (2R)-2-[(4-fluoro-3-methoxybenzene-1-sulfonyl)(2-methylpropyl)amino]-N-hydroxy-3-methylbutanamide
0.95
-
 pH and temperature not specified in the publication Bacillus anthracis N-hydroxy-N2-[[3-(methoxymethyl)phenyl]sulfonyl]-N2-(2-methylpropyl)-D-valinamide