Application | Comment | Organism |
---|---|---|
medicine | the use of drugs capable of inhibiting Rho GTPase activity, such as statins, may provide a means to attenuate intoxication during Bacillus anthracis infection | Bacillus anthracis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
fluvastatin | statins attenuate lethal factor action action. statin treatment maintains macrophage cell viability above 60% of untreated control cells even after 9 h of lethal toxin treatment. Statins decrease mitogen-activated protein kinase cleavage | Bacillus anthracis | |
mevastatin | statins attenuate lethal factor action action. statin treatment maintains macrophage cell viability above 60% of untreated control cells even after 9 h of lethal toxin treatment. Statins decrease mitogen-activated protein kinase cleavage | Bacillus anthracis | |
additional information | statin-mediated effects on lethal toxin action are attributable to disruption of Rho GTPases. The Rho GTPase-inactivating toxin, toxin B, does not significantly affect lethal toxin binding or internalization, suggesting that the Rho GTPases regulate trafficking and/or localization of lethal toxin once internalized | Bacillus anthracis | |
simvastatin | statins attenuate lethal factor action action. statin treatment maintains macrophage cell viability above 60% of untreated control cells even after 9 h of lethal toxin treatment. Statins decrease mitogen-activated protein kinase cleavage | Bacillus anthracis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bacillus anthracis | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
mitogen-activated protein kinase + H2O | - |
Bacillus anthracis | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
anthrax lethal toxin | - |
Bacillus anthracis |