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Literature summary for 3.4.24.40 extracted from

  • Laarman, A.J.; Bardoel, B.W.; Ruyken, M.; Fernie, J.; Milder, F.J.; van Strijp, J.A.; Rooijakkers, S.H.
    Pseudomonas aeruginosa alkaline protease blocks complement activation via the classical and lectin pathways (2012), J. Immunol., 188, 386-393.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
human complement component C1 + H2O Pseudomonas aeruginosa
-
 ?
-
 ?
human complement component C2 + H2O Pseudomonas aeruginosa
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
human complement component C1 + H2O
-
 Pseudomonas aeruginosa ?
-
 ?
human complement component C2 + H2O
-
 Pseudomonas aeruginosa ?
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 ?

Synonyms

Synonyms Comment Organism
AprA
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 Pseudomonas aeruginosa
Pseudomonas aeruginosa alkaline protease
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 Pseudomonas aeruginosa

General Information

General Information Comment Organism
physiological function the alkaline protease AprA is associated with bacterial virulence and interferes with complement-mediated lysis of erythrocytes and complement activation. AprA potently blocks phagocytosis and killing of Pseudomonas by human neutrophils. AprA inhibits opsonization of bacteria with C3b and the formation of the chemotactic agent C5a. AprA specifically blocks C3b deposition via the classical and lectin pathways, whereas the alternative pathway is not affected. AprA degrades both human C1s and C2, and the mechanism of action for complement inhibition is cleavage of C2, overview Pseudomonas aeruginosa