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Information on EC 3.4.24.40 - serralysin

for references in articles please use BRENDA:EC3.4.24.40

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IUBMB Comments

A 50 kDa extracellular endopeptidase from Pseudomonas aeruginosa [1,2,6], Escherichia freundii , Serratia marcescens [4,5,6] and Erwinia chrysanthemi . There is broad specificity in cleavage of the insulin B chain, with some species variations. The pH optimum for digesting various proteins is about 9 - 10. In peptidase family M10 (interstitial collagenase family). Formerly included in EC 3.4.24.4

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Reaction Schemes
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Preferential cleavage of bonds with hydrophobic residues in P1'

Synonyms
protease i, serralysin, arazyme, protease c, extracellular metalloproteinase, zinc proteinase, thermostable alkaline protease, pseudomonas aeruginosa alkaline protease, amp-p, thermoalkaline protease, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
Preferential cleavage of bonds with hydrophobic residues in P1'
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