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Literature summary for 3.4.24.26 extracted from

  • Casilag, F.; Lorenz, A.; Krueger, J.; Klawonn, F.; Weiss, S.; Haeussler, S.
    The LasB elastase of Pseudomonas aeruginosa acts in concert with alkaline protease AprA to prevent flagellin-mediated immune recognition (2016), Infect. Immun., 84, 162-171 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.26

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Pseudomonas aeruginosa
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
flagellin + H2O Pseudomonas aeruginosa the enzyme is capable of degrading exogenous flagellin under calcium-replete conditions and prevents flagellin-mediated immune recognition ?
-
 ?
flagellin + H2O Pseudomonas aeruginosa UCBPP-PA14 the enzyme is capable of degrading exogenous flagellin under calcium-replete conditions and prevents flagellin-mediated immune recognition ?
-
 ?

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa Q02RJ6
-
-
Pseudomonas aeruginosa UCBPP-PA14 Q02RJ6
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification LasB is produced as a precursor protein that requires autocatalytic processing to ensure proper folding as it is exported across the outer membrane. Ca2+ is needed either for efficient transcription of lasB or during the process of folding and export, as calcium plays a role in the structural integrity of LasB Pseudomonas aeruginosa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
flagellin + H2O the enzyme is capable of degrading exogenous flagellin under calcium-replete conditions and prevents flagellin-mediated immune recognition Pseudomonas aeruginosa ?
-
 ?
flagellin + H2O the enzyme is capable of degrading exogenous flagellin under calcium-replete conditions and prevents flagellin-mediated immune recognition Pseudomonas aeruginosa UCBPP-PA14 ?
-
 ?

Synonyms

Synonyms Comment Organism
ealastase LasB
-
 Pseudomonas aeruginosa

Expression

Organism Comment Expression
Pseudomonas aeruginosa it is possible that the induction of LasB production is increased by the combined regulatory activities of the Las and Rhl systems in a manner not applicable to AprA up

General Information

General Information Comment Organism
physiological function virulence factor Pseudomonas aeruginosa