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Information on EC 3.4.24.26 - pseudolysin

for references in articles please use BRENDA:EC3.4.24.26

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IUBMB Comments

In peptidase family M4 (thermolysin family). From the pathogenic bacteria Pseudomonas aeruginosa and Legionella pneumophila, and causes tissue damage.

The enzyme appears in viruses and cellular organisms
Reaction Schemes
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Hydrolysis of proteins including elastin, collagen types III and IV, fibronectin and immunoglobulin A, generally with bulky hydrophobic group at P1'. Insulin B chain cleavage pattern identical to that of thermolysin, but specificity differs in other respects

Synonyms
pseudomonas aeruginosa elastase, pseudolysin, neutral metalloproteinase, pseudomonas elastase, elastase b, pseudomonas protease, elastolytic metalloproteinase, aeruginolysin, lasb protease, a2 elastase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
Hydrolysis of proteins including elastin, collagen types III and IV, fibronectin and immunoglobulin A, generally with bulky hydrophobic group at P1'. Insulin B chain cleavage pattern identical to that of thermolysin, but specificity differs in other respects
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