Literature summary for 3.4.22.51 extracted from

Cianni, L.; Sartori, G.; Rosini, F.; De Vita, D.; Pires, G.; Lopes, B.R.; Leitao, A.; Burtoloso, A.C.B.; Montanari, C.A.
Leveraging the cruzain S3 subsite to increase affinity for reversible covalent inhibitors (2018), Bioorg. Chem., 79, 285-292 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
N-(1-cyanocyclopropyl)-Nalpha-(phenylacetyl)-L-phenylalaninamide	pKi: 6.4 (-log(Ki/M))	Trypanosoma cruzi
N-(1-cyanocyclopropyl)-Nalpha-[(4-fluorophenyl)acetyl]-L-phenylalaninamide	pKi: 6.3 (-log(Ki/M))	Trypanosoma cruzi
N-(1-cyanocyclopropyl)-Nalpha-[(4-hydroxyphenyl)acetyl]-L-phenylalaninamide	pKi: 7.0 (-log(Ki/M))	Trypanosoma cruzi
N-(1-cyanocyclopropyl)-Nalpha-[(4-iodophenyl)acetyl]-L-phenylalaninamide	pKi: 7.2 (-log(Ki/M))	Trypanosoma cruzi
N-(1-cyanocyclopropyl)-Nalpha-[(4-methylphenyl)acetyl]-L-phenylalaninamide	pKi: 6.6 (-log(Ki/M))	Trypanosoma cruzi
N-(1-cyanocyclopropyl)-Nalpha-[(pyridin-4-yl)acetyl]-L-phenylalaninamide	pKi: 5.9 (-log(Ki/M))	Trypanosoma cruzi
N-(1-cyanocyclopropyl)-Nalpha-[[4-(trifluoromethyl)phenyl]acetyl]-L-phenylalaninamide	pKi: 6.6 (-log(Ki/M))	Trypanosoma cruzi
Nalpha-[(3-chlorophenyl)acetyl]-N-(1-cyanocyclopropyl)-L-phenylalaninamide	pKi: 6,4 (-log(Ki/M)); pKi: 6.6 (-log(Ki/M))	Trypanosoma cruzi
Nalpha-[(4-bromophenyl)acetyl]-N-(1-cyanocyclopropyl)-L-phenylalaninamide	pKi: 6.9 (-log(Ki/M))	Trypanosoma cruzi
Nalpha-[(4-chlorophenyl)acetyl]-N-(1-cyanocyclopropyl)-L-phenylalaninamide	pKi: 7.2 (-log(Ki/M))	Trypanosoma cruzi

Organism

Organism	UniProt	Comment	Textmining
Trypanosoma cruzi	P25779	-	-

Synonyms

Synonyms	Comment	Organism
cruzain	-	Trypanosoma cruzi

General Information

General Information	Comment	Organism
physiological function	the enzyme is the etiological agent of Chagas disease	Trypanosoma cruzi

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Release 2023.1 (January 2023)