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Literature summary for 3.4.22.51 extracted from
- First quantum mechanics/molecular mechanics studies of the inhibition mechanism of cruzain by peptidyl halomethyl ketones (2015), Biochemistry, 54, 3381-3391 .
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | cruzain is a primary cysteine protease expressed by the protozoan parasite Trypanosoma cruzi during Chagas disease infection, and thus, the development of inhibitors of this protein is a promising target for designing an effective therapy against the disease | Trypanosoma cruzi |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| benzoyl-Tyr-Ala-chloromethyl ketone | first quantum mechanics/molecular mechanics studies show that benzoyl-Tyr-Ala-chloromethyl ketone is a good candidate for the development of a proper inhibitor of cruzain, which in turn can be used in the treatment of Chagas desease | Trypanosoma cruzi |  |
| benzoyl-Tyr-Ala-fluoromethyl ketone | - |
Trypanosoma cruzi | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Trypanosoma cruzi | P25779 | - |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| cruzain | - |
Trypanosoma cruzi |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | the enzyme is expressed by the protozoan parasite Trypanosoma cruzi during Chagas disease infection | Trypanosoma cruzi |
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