Literature summary for 3.4.22.32 extracted from
Manosroi, W.; Chankhampan, C.; Manosroi, J.; Manosroi, A.
In vitro anti-cancer activity comparison of the freeze-dried and spray-dried bromelain from pineapple stems (2017), Chiang Mai J. Sci., 44, 1407-1418 .
No PubMed abstract available
Application
Application |
Comment |
Organism |
medicine |
potential of the stem bromelain to be developed as an active compound for lung cancer therapy because of its high anti-proliferation and apoptosis-induction activity in A549 cells |
Ananas comosus |
pharmacology |
in vitro anti-cancer activity (anti-proliferation and apoptosis induction) comparison of the freeze-dried and spray-dried bromelain from pineapple stems |
Ananas comosus |
Organism
Organism |
UniProt |
Comment |
Textmining |
Ananas comosus |
P14518 |
from Thailand |
- |
Purification (Commentary)
Purification (Comment) |
Organism |
bromelain is precipitated from the pineapple stem juice by 95% v/v ethanol and then freeze-dried or spray-dried to get the dry powder |
Ananas comosus |
Source Tissue
Source Tissue |
Comment |
Organism |
Textmining |
stem |
- |
Ananas comosus |
- |
Substrates and Products (Substrate)
Substrates |
Comment Substrates |
Organism |
Products |
Comment (Products) |
Rev. |
Reac. |
casein + H2O |
- |
Ananas comosus |
? |
- |
? |
|
General Information
General Information |
Comment |
Organism |
physiological function |
the highest anti-proliferation of the freeze-dried and the spray-dried bromelain versus A549 cells are observed with IC50 values of 0.0183 and 0.0264 mg/ml, respectively. For apoptotic induction, the highest activity of the freeze-dried and the spray-dried bromelain is observed on KB (7.53%) and A549 (6.29%) cell lines, respectively. Stem bromelain exhibits apoptotic induction activity on DU145, HT-29, A549, KB, HeLa, and HuTu-80 cells, but not on Hep-G2 cells |
Ananas comosus |