Activating Compound | Comment | Organism | Structure |
---|---|---|---|
A23187 | induces granzyme B expression in mast cell lines HMC-1 and LAD2 and cord blood-derived mast cells | Homo sapiens | |
compound 48/80 | induces granzyme B expression in mast cell line LAD2 and cord blood-derived mast cells | Homo sapiens | |
additional information | mature skin-derived mast cells only produce granzyme B upon IgE-dependent stimulation by FcepsilonRI | Homo sapiens | |
PMA | stimulates | Homo sapiens | |
SERPINB9 | - |
Homo sapiens | |
Substance P | induces granzyme B expression in mast cell line LAD2 and cord blood-derived mast cells | Homo sapiens |
Application | Comment | Organism |
---|---|---|
additional information | role for granzyme B as mediator in mast cell biology | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | active in cytoplasmic granules, mainly located in the dense core, partially colocalizes with tryptase in granules with both lysosomal and secretory features | Homo sapiens | 5737 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colon | between smooth muscle cells | Homo sapiens | - |
mast cell | cord blood- and mature skin-derived mast cells. Majority of lesional mast cells express abundant GrB | Homo sapiens | - |
additional information | unstimulted HMC-1 cells and LAD 2 cells show no Grb mRNA and protein, expression upon stimulation with non-physiological stimuli | Homo sapiens | - |
skin | around skin appendages | Homo sapiens | - |
tonsil | around small vessels | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-Ile-Glu-Thr-Asp-p-nitroanilide + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cytotoxic lymphocyte-associated protease | - |
Homo sapiens |
cytotoxic lymphocyte-specific protein | - |
Homo sapiens |
GrB | - |
Homo sapiens |