Application | Comment | Organism |
---|---|---|
medicine | pleiotropic pro-apoptotic function of gzmB presumably to counteract evasion strategies of pathogens and to control tumors | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | gzmB-/-CTL cells, no cleavage of Bid | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
B6 background | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cytotoxic T-lymphocyte cell line | expresses gzmB. Positive gzmB cytotoxic T-lymphocyte cells abrogate target cell proliferation by inducing cell death, independent of caspases and mitochondrial signaling. Positive gzmB cytotoxic T-lymphocyte cells independently induce pro-apoptotic processes either via caspase-3/-7, leading to plasma membrane perturbance and ROS production or via Bid/Bak/Bax, resulting in cytochrome c release, whereby both pathways elicit loss of mitochondrial membrane potential | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
BID + H2O | - |
Mus musculus | truncated BID + ? | - |
? | |
pro-caspase-3 + H2O | - |
Mus musculus | caspase-3 + ? | - |
? | |
pro-caspase-7 + H2O | - |
Mus musculus | caspase-7 + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GzmB | - |
Mus musculus |