Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | induction of granzyme B by a DNase1 hypersensitive site 3.9 kb upstream of the transcription start site of granzyme B | Mus musculus |
Cloned (Comment) | Organism |
---|---|
CTLL R8 cell line stably transfected with GFP reporter constructs | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | deletion of the DNase1 hypersensitive site upstream of the granzyme B gene results in a 10fold reduction in expression | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
C57 and Balb/C mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | in activated but not resting primary CD8+ T cells, a DNase1 hypersensitive site pesent upstream of the granzyme B gene. Thymocytes do not express granzyme B. MTL 2.8.2 cell line constitutively expresses granzyme B at a high level. CTLL R8 cell line constitutively expresses endogenous granzyme B gene | Mus musculus | - |
splenocyte | - |
Mus musculus | - |