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Literature summary for 3.4.21.78 extracted from

  • Velaga, S.; Ukena, S.; Dringenberg, U.; Alter, C.; Pardo, J.; Kershaw, O.; Franzke, A.
    Granzyme a is required for regulatory T-cell mediated prevention of gastrointestinal graft-versus-host disease (2015), PLoS ONE, 10, e0124927 .
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
additional information cell depleted bone marrow cells (TCD BM) and isolated T cell populations of wild type (WT) and gzmA-/- C57/BL6 donor mice are transferred into the BALB/c recipient mice after lethal irradiation. Immune tolerant and GvHD mice are monitored comparatively after adoptive T cell transfer for incidence, severity and clinical manifestation of GvHD by clinical and histopathological grading. After irradiation and transplantation the body weight of recipient mice declines in all treatment groups and increases again one week after transplantation. But two weeks after transplantation, mice from the GvHD group continuously lost weight in contrast to the immune tolerant groups. Histopathological investigations confirm a severe inflammation especially in the small and large intestine as GvHD target organs. Enzyme-deficient gzmA-/- Tregs cannot efficiently protect from GvHD-related inflammation and organ destruction in the intestinal tract with relevant crypt apoptosis detected in the small and large intestine Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus P11032
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-

Source Tissue

Source Tissue Comment Organism Textmining
gastrointestinal tract
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 Mus musculus
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large intestine
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 Mus musculus
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small intestine
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 Mus musculus
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splenocyte
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 Mus musculus
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T-lymphocyte regulatory T cells (Tregs), CD4+ T-cells and CD4+CD25- T-cells from wild-type and gzmA-/- mice Mus musculus
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Synonyms

Synonyms Comment Organism
Gzma
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 Mus musculus

General Information

General Information Comment Organism
malfunction phenotypic characterization of gzmA-/- regulatory T cells (Tregs) efficiently homing to secondary lymphoid organs, GzmA-/- Tregs home efficiently to secondary lymphoid organs, overview. No difference between wild-type and GZMA-/- mice in Treg numbers in spleen and peripheral lymph nodes. Enzyme-deficient gzmA-/- Tregs cannot efficiently protect from GvHD-related inflammation and organ destruction in the intestinal tract with relevant crypt apoptosis detected in the small and large intestine Mus musculus
physiological function granzyme A is required for regulatory T-cell mediated prevention of gastrointestinal graft-versus-host disease. Analysis of the role of granzyme A (GZMA) in a haploidentical murine graft-versus-host disease (GvHD) model using gzmA-/- donor regulatory T cells (Tregs) to clarify the functional relevance of GZMA for Treg-mediated suppression of GvHD. GZMA expressing Tregs protect against GvHD-related tissue damage of the intestine Mus musculus