Literature summary for 3.4.21.78 extracted from

Zhu, P.; Zhang, D.; Chowdhury, D.; Martinvalet, D.; Keefe, D.; Shi, L.; Lieberman, J.
Granzyme A, which causes single-stranded DNA damage, targets the double-strand break repair protein Ku70 (2006), EMBO Rep., 7, 431-437.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
Ku70 double strand break repair protein + H2O	Homo sapiens	-	?	cleavage of Ku70 after R301, disrupting Ku complex binding to DNA and blocking of Ku70 antiapoptotic functions	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Ku70 double strand break repair protein + H2O	-	Homo sapiens	?	cleavage of Ku70 after R301, disrupting Ku complex binding to DNA and blocking of Ku70 antiapoptotic functions	?
Ku70 double strand break repair protein + H2O	-	Homo sapiens	?	cleavage of Ku70 after R301, disrupting Ku complex binding to DNA	?

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Release 2023.1 (January 2023)