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Literature summary for 3.4.21.78 extracted from

  • Zhu, P.; Zhang, D.; Chowdhury, D.; Martinvalet, D.; Keefe, D.; Shi, L.; Lieberman, J.
    Granzyme A, which causes single-stranded DNA damage, targets the double-strand break repair protein Ku70 (2006), EMBO Rep., 7, 431-437.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Ku70 double strand break repair protein + H2O Homo sapiens
-
 ? cleavage of Ku70 after R301, disrupting Ku complex binding to DNA and blocking of Ku70 antiapoptotic functions ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ku70 double strand break repair protein + H2O
-
 Homo sapiens ? cleavage of Ku70 after R301, disrupting Ku complex binding to DNA and blocking of Ku70 antiapoptotic functions ?
Ku70 double strand break repair protein + H2O
-
 Homo sapiens ? cleavage of Ku70 after R301, disrupting Ku complex binding to DNA ?