Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | efficacy of grape seed extract in negatively regulating uPA expression and cell migration using highly metastatic androgen-independent PC3 prostate cancer cells as a model. Grape seed extract inhibits and downregulates NFkB-dependent urokinase plasminogen activator promoter activity | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
PC-3 cell | - |
Homo sapiens | - |
prostate cancer cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
uPA | - |
Homo sapiens |
Urokinase plasminogen activator | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | efficacy of grape seed extract in downregulating uPA expression and cell migration using highly metastatic androgen-independent PC-3 prostate cancer cells as a model. Grape seed extract inhibits DNA-binding activity of the transcription factor nuclear factor kappa B, which in turn decreases NFkB-dependent uPA transcription. Grape seed extract also inhibits NFkB-dependent urokinase plasminogen activator promoter activity | down |
General Information | Comment | Organism |
---|---|---|
metabolism | NFkappaB-dependent regulation of urokinase plasminogen activator | Homo sapiens |
physiological function | the urokinase plasminogen activator system is implicated in cell migration and cancer metastasis | Homo sapiens |