Cloned (Comment) | Organism |
---|---|
expression of wild-type and mutant enzymes in EA.hy926 cells, co-expression with activated protein C | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
R155A/R271A/R286A | site-directed mutagenesis, the mutation of enzyme's proteolytic cleavage sites hinder the activation of the enzyme | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | - |
Homo sapiens | 9986 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the ligand occupancy of endothelial protein C receptor by caveolin-1 switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells, overview | ? | - |
? | |
protease-activated receptor 1 + H2O | Homo sapiens | endothelial protein C receptor-dependent cleavage of PAR-1 on vascular endothelial cells, the enzyme exhibts anti-inflammatory activity | ? | - |
? | |
protein C zymogen + H2O | Homo sapiens | on vascular endothelial cells | activated protein C + propeptide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | prothrombin requires activation by proteolytic cleavage, clevage sites are R155, R271, and R286, in vitro activation by Taipan snake venom | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endothelial cell | vascular, cell surface | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the ligand occupancy of endothelial protein C receptor by caveolin-1 switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells, overview | Homo sapiens | ? | - |
? | |
protease-activated receptor 1 + H2O | endothelial protein C receptor-dependent cleavage of PAR-1 on vascular endothelial cells, the enzyme exhibts anti-inflammatory activity | Homo sapiens | ? | - |
? | |
protease-activated receptor 1 + H2O | endothelial protein C receptor-dependent cleavage of PAR-1 | Homo sapiens | ? | - |
? | |
protein C zymogen + H2O | - |
Homo sapiens | activated protein C + propeptide | - |
? | |
protein C zymogen + H2O | on vascular endothelial cells | Homo sapiens | activated protein C + propeptide | - |
? |