Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | complement activation via the lectin pathway on zymosan particles is at least 4times more efficient than via the classical pathway on sheep erythrocytes coated with antibody. Every C4b deposited via the lectin pathway is capable of forming a convertase in contrast to only one of four C4b molecules deposited via the classical pathway. Rate of formation of lectin pathway C3/C5 convertases depends on the activation of C4 and C2 by MASP-2 | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | activation of complement via the lectin pathway may be a more prominent contributor to the pathology of inflammatory reactions as compared to activation of complement via the classical pathway | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000051 | - |
complement component C5 | high affinity C5 convertase (EAC1,C3bC4b,C2a) | Homo sapiens | |
0.0056 | - |
complement component C5 | surface-bound C5 convertase (EAC1,C4b,C2a) | Homo sapiens | |
0.0089 | - |
complement component C5 | soluble monomeric C5 convertase (C4b,C2a) | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
complement proteins purified by gel filtration, to homogeneity | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
plasma | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
complement component C5 + H2O | - |
Homo sapiens | complement component C5a + complement component C5b | - |
? |
Synonyms | Comment | Organism |
---|---|---|
C3/C5 convertase | - |
Homo sapiens |
C5 convertase | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.02 | - |
complement component C5 | high affinity C5 convertase (EAC1,C3bC4b,C2a) | Homo sapiens | |
0.022 | - |
complement component C5 | soluble monomeric C5 convertase (C4b,C2a) | Homo sapiens | |
0.03 | - |
complement component C5 | surface-bound C5 convertase (EAC1,C4b,C2a) | Homo sapiens |