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Information on EC 3.4.21.43 - classical-complement-pathway C3/C5 convertase

for references in articles please use BRENDA:EC3.4.21.43

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IUBMB Comments

A complex of complement fragments C4b, C2a and C2b. C2a contains the active site, C2b the site for C4b binding. C2a and C2b are formed by cleavage of proenzyme C2 by complement subcomponent C1s. Cleavage of C5 requires complement fragment C3b which binds C5 and renders it susceptible to cleavage by the C4b,2a complex. Includes former EC 3.4.21.44. Complement component C2a is in peptidase family S1 (trypsin family)

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
Selective cleavage of Arg-/-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg-/- bond in complement component C5 alpha-chain to form C5a and C5b

Synonyms
c3bbbp, c4b2a, classical pathway c3 convertase, classical c3 convertase, c4b,2a, classical pathway c5 convertase, complement c3 convertase, cp c3 convertase, c4bc2a, classical c5 convertase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
Selective cleavage of Arg-/-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg-/- bond in complement component C5 alpha-chain to form C5a and C5b
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