Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,10-phenanthroline | - |
Homo sapiens | |
CP-013043 | - |
Homo sapiens | |
CP-143217 | - |
Homo sapiens | |
CP-349547 | - |
Homo sapiens | |
FUT175 | potent C1s inhibitor | Homo sapiens | |
PHA-00737785 | - |
Homo sapiens | |
serine protease inhibitor 1 | - |
Homo sapiens | |
serine protease inhibitor 2 | - |
Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
86000 | - |
1 * 88000 ,immunoblotting, both joint fluid and purified material, 1 * 90000, SDS-PAGE and 1 * 86000, SDS-PAGE | Homo sapiens |
88000 | - |
1 * 88000 ,immunoblotting, both joint fluid and purified material, 1 * 90000, SDS-PAGE and 1 * 86000, SDS-PAGE | Homo sapiens |
90000 | - |
1 * 88000 ,immunoblotting, both joint fluid and purified material, 1 * 90000, SDS-PAGE and 1 * 86000, SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
by gel filtration and on affinity column | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
insulin-like growth factor-I binding protein-5 + H2O | C1s accounts for the proteolytic activity in human osteoarthritis fluid for insulin-like growth factor-I binding protein-5 | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 88000 ,immunoblotting, both joint fluid and purified material, 1 * 90000, SDS-PAGE and 1 * 86000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
C1s | - |
Homo sapiens |
complement 1s | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00007 | - |
- |
Homo sapiens | CP-143217 | |
0.001 | - |
- |
Homo sapiens | CP-349547 | |
0.001 | - |
- |
Homo sapiens | CP-013043 | |
0.0103 | - |
- |
Homo sapiens | PHA-00737785 | |
0.1 | - |
- |
Homo sapiens | 1,10-phenanthroline | |
0.1 | - |
- |
Homo sapiens | FUT175 | |
0.1 | - |
- |
Homo sapiens | serine protease inhibitor 1 | |
0.1 | - |
- |
Homo sapiens | serine protease inhibitor 2 |