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Literature summary for 3.4.21.37 extracted from

  • Salipante, S.J.; Rojas, M.E.; Korkmaz, B.; Duan, Z.; Wechsler, J.; Benson, K.F.; Person, R.E.; Grimes, H.L.; Horwitz, M.S.
    Contributions to neutropenia from PFAAP5 (N4BP2L2), a novel protein mediating transcriptional repressor cooperation between Gfi1 and neutrophil elastase (2009), Mol. Cell. Biol., 29, 4394-4405.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.37

Activating Compound

Activating Compound Comment Organism Structure
additional information enhancement of neutrophil elastase corepressor activity through nuclear localization Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression of neutrophil elastase and phosphonoformate immunoassociated protein in the yeast two hybrid system, overall protein interaction analysis, overview. PFAAP5 coimmunoprecipitates with neutrophil elastase and Gfi1 in transfected NIH 3T3 cells expressing the Myc-tagged proteins Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information nuclear localization of neutrophil elastase enhances Gfi1 corepressor activity in reporter assays in recombinant NIH 3T3 cells. Silencing of neutrophil elastase, Gfi1, or PFAAP5 upregulates ELA2 and AZU1 in HL-60 promyelocytes Homo sapiens
N95A/N144A the neutrophil elastase glycosylation variant is located in the nucleus Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasmic vesicle predominantly Homo sapiens 31410
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nucleus neutrophil elastase N95A/N144A glycosylation variant in the nucleus. Nuclear localization of neutrophil elastase enhances Gfi1 corepressor activity in reporter assays in recombinant NIH 3T3 cells Homo sapiens 5634
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens neutrophil elastase interacts with phosphonoformate immunoassociated protein 5, i.e. PFAAP5 or N4BP2L2, with potential participation in a feedback circuit in which neutrophil elastase regulates its own transcription ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein neutrophil elastase N95A/N144A glycosylation variant is located in the nucleus Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
leukocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information neutrophil elastase interacts with phosphonoformate immunoassociated protein 5, i.e. PFAAP5 or N4BP2L2, with potential participation in a feedback circuit in which neutrophil elastase regulates its own transcription Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
neutrophil elastase
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 Homo sapiens