Literature summary for 3.4.21.36 extracted from

Hilpert, K.; Wessner, H.; Schneider-Mergener, J.; Welfle, K.; Misselwitz, R.; Welfle, H.; Hocke, A.C.; Hippenstiel, S.; Hohne, W.
Design and characterization of a hybrid miniprotein that specifically inhibits porcine pancreatic elastase (2003), J. Biol. Chem., 278, 24986-24993.

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Inhibitors

Inhibitors	Comment	Organism	Structure
EETI II	trypsin-specific squash inhibitor from Ecballium elaterium	Sus scrofa
HEI-TOE I	hybrid inhibitor from Ecballium elaterium and the optimized binding loop of the third domain of turkey ovomucoid inhibitor	Sus scrofa
HEI-TOE II	-	Sus scrofa
HEI-TOE III	-	Sus scrofa
MCEI III	-	Sus scrofa
OMTKY3	third Kazal-type domain of ovomucoid inhibitor from turkey egg white	Sus scrofa
PACTLEYRC	-	Sus scrofa
PMTLEYR	-	Sus scrofa

Organism

Organism	UniProt	Comment	Textmining
Sus scrofa	P00772	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
succinyl-Ala-Ala-Phe-4-nitroanilide + H2O	-	Sus scrofa	succinyl-Ala-Ala-Phe + 4-nitroaniline	-	?

Synonyms

Synonyms	Comment	Organism
PPE	-	Sus scrofa

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.000000024	-	OMTKY3	pH 8.5, 25°C	Sus scrofa
0.000013	-	MCEI III	pH 8.5, 25°C	Sus scrofa
0.000049	-	PMTLEYR	pH 5.5, 25°C	Sus scrofa
0.000056	-	HEI-TOE III	pH 8.5, 25°C	Sus scrofa
0.00007	-	HEI-TOE II	pH 8.5, 25°C	Sus scrofa
0.000098	-	HEI-TOE I	pH 8.5, 25°C	Sus scrofa
0.00013	-	HEI-TOE I	pH 6.5, 25°C	Sus scrofa
0.00024	-	HEI-TOE III	pH 5.0, 25°C	Sus scrofa
0.00029	-	HEI-TOE III	pH 7.5, 25°C	Sus scrofa
0.00031	-	HEI-TOE III	pH 6.5, 25°C	Sus scrofa
0.00033	-	HEI-TOE I	pH 5.5, 25°C	Sus scrofa
0.00038	-	HEI-TOE I	pH 7.5, 25°C	Sus scrofa
0.00063	-	PMTLEYR	pH 7.5, 25°C	Sus scrofa
0.00067	-	PMTLEYR	pH 8.5, 25°C	Sus scrofa
0.0013	-	PMTLEYR	pH 6.5, 25°C	Sus scrofa
0.17	-	PACTLEYRC	pH 8.5, 25°C	Sus scrofa
0.82	-	EETI II	pH 8.5, 25°C	Sus scrofa

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Release 2023.1 (January 2023)