Any feedback?
Literature summary for 3.4.21.105 extracted from
- An alternative processing pathway of APP reveals two distinct cleavage modes for rhomboid protease RHBDL4 (2018), Biol. Chem., 399, 1399-1408 .
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | introduction of positively charged amino acid residues in the transmembrane sequence of the substrate redirects the RHBDL4-mediated cleavage of amyloid precursor protein from its ectodomain closer towards the transmembrane sequence, possibly inducing an ER-associated degradation of the substrate. The cytoplasmic tail and proposed palmitoylation sites in the ectodomain of amyloid precursor protein are not essential for the RHBDL4-mediated amyloid precursor protein processing | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| transfection of HEK-293T cell | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| S144A | inactive | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| amyloid precursor protein + H2O | - |
Homo sapiens | ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| RHBDL4 | - |
Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
