Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9H300 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293A cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphoglycerate mutase 5 + H2O | mitochondrial Ser/Thr protein phosphatase PGAM5 | Homo sapiens | ? | substrate is cleaved in its N-terminal transmembrane domain in response to mitochondrial membrane potential loss and mediated by presenilin-associated rhomboid-like protein. In response to membrane potential loss, the enzyme dissociates from substrate PINK1, a mitochondrial Ser/Thr protein kinase, and reciprocally associates with substrate PGAM5. Results suggest that the enzyme mediates differential cleavage of PINK1 and PGAM5 depending on the health status of mitochondria | ? |
Synonyms | Comment | Organism |
---|---|---|
PARL | - |
Homo sapiens |
presenilin-associated rhomboid-like protein | - |
Homo sapiens |