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Literature summary for 3.4.17.23 extracted from

  • Lee, J.H.; Lee, Y.; Lee, S.K.; Kim, J.; Lee, C.S.; Kim, N.H.; Kim, H.G.
    Versatile role of ACE2-based biosensors for detection of SARS-CoV-2 variants and neutralizing antibodies (2022), Biosens. Bioelectron., 203, 114034 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
analysis ACE2-based biosensor designed to detect both SARS-CoV-2 S1 mutations and neutralizing antibodies. In binding mode, the biosensor works by detecting binding of the spike protein to an immobilized ACE2 receptor and is able to detect S1 proteins of the alpha (500 pg/ml) and beta variants (10 ng/ml), as well as wild-type S1 (10 ng/ml), of SARSCoV-2 and it distinguishes wild-type SARS-CoV-2 S1 from the S1 alpha and beta variants via color differences. A modification to the protocol enables the ACE2-based biosensor to operate in blocking mode to detect neutralizing antibodies in serum samples from COVID-19 patients Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9BYF1
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