Literature summary for 3.4.17.23 extracted from

Miller, A.; Leach, A.; Thomas, J.; McAndrew, C.; Bentley, E.; Mattiuzzo, G.; John, L.; Mirazimi, A.; Harris, G.; Gamage, N.; Carr, S.; Ali, H.; Van Montfort, R.; Rabbitts, T.
A super-potent tetramerized ACE2 protein displays enhanced neutralization of SARS-CoV-2 virus infection (2021), Sci. Rep., 11, 10617 .

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Application

Application	Comment	Organism
drug development	a super-potent tetramerized ACE2 protein displays enhanced neutralization of SARS-CoV-2 virus infection	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9BYF1	-	-

Subunits

Subunits	Comment	Organism
tetramer	a super-potent tetravalent form of ACE2 is produced by protein engineering technology, that couples to the human immunoglobulin gamma1 Fc region, using a self-assembling, tetramerization domain from p53 protein. This high molecular weight Quad protein (ACE2-Fc-TD) retains binding to the SARS-CoV-2 receptor binding spike protein and can form a complex with the spike protein plus anti-viral antibodies. The ACE2-Fc-TD acts as a powerful decoy protein that out-performs soluble monomeric and dimeric ACE2 proteins and blocks both SARS-CoV-2 pseudovirus and SARS-CoV-2 virus infection with greatly enhanced efficacy	Homo sapiens

Synonyms

Synonyms	Comment	Organism
ACE2	-	Homo sapiens

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Release 2023.1 (January 2023)