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Literature summary for 3.4.17.21 extracted from

  • Castelletti, D.; Fracasso, G.; Alfalah, M.; Cingarlini, S.; Colombatti, M.; Naim, H.Y.
    Apical transport and folding of prostate-specific membrane antigen occurs independent of glycan processing (2006), J. Biol. Chem., 281, 3505-3512.
    View publication on PubMed
Search for more literature for 3.4.17.21

Cloned(Commentary)

Cloned (Comment) Organism
expression in COS-1 cells, mannose-rich glycosylation of the recombinant enzyme in absence of an inhibitor, recombinant glycosylation and subcellular transport analysis, overview, stable expression in MDCK cells at the cell surface Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
 Homo sapiens 9986
-
plasma membrane type II transmembrane glycoprotein Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O Homo sapiens
-
 N-acetyl-alpha-L-aspartate + L-glutamate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein type II transmembrane glycoprotein, N- and O-glycosylation, mannose-rich glycosylation renders the enzyme trypsin-insensitive, which is typical for Golgi-located enzyme, overview Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
prostate
-
 Homo sapiens
-
prostate carcinoma cell overexpression of PMSA Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O
-
 Homo sapiens N-acetyl-alpha-L-aspartate + L-glutamate
-
 ?
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O i.e. NAAG Homo sapiens N-acetyl-alpha-L-aspartate + L-glutamate
-
 ?

Synonyms

Synonyms Comment Organism
Prostate-specific membrane antigen
-
 Homo sapiens
PSMA
-
 Homo sapiens