Literature summary for 3.4.17.20 extracted from

Leenaerts, D.; Aernouts, J.; Van Der Veken, P.; Sim, Y.; Lambeir, A.M.; Hendriks, D.
Plasma carboxypeptidase U (CPU, CPB2, TAFIa) generation during in vitro clot lysis and its interplay between coagulation and fibrinolysis (2017), Thromb. Haemost., 117, 1498-1508 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q96IY4	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	the inactive precursor procarboxypeptidase U is converted to its active form by thrombin, the thrombin-thrombomodulin complex or plasmin	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood plasma	in all individuals, carboxypeptidase U generation is biphasic. Marked inter-individual differences are present and a reference range is determined. The endogenous Carboxypeptidase U generation potential is the composite effect of multiple factors. With respect to the first carboxypeptidase U activity peak characteristics, a correlations with baseline proCPU concentration, proCPU Thr325Ile polymorphism, time to clot initiation and the clot lysis time is detected. The second CPU peak is related with baseline proCPU levels and with the maximum turbidity of the clot lysis profile	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
benzoyl-o-cyano-Phe-Arg + H2O	-	Homo sapiens	benzoyl-o-cyano-Phe + Arg	-	?

Synonyms

Synonyms	Comment	Organism
CPB2	-	Homo sapiens
CPU	-	Homo sapiens
TAFIa	-	Homo sapiens

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Release 2023.1 (January 2023)