BRENDA - Enzyme Database
show all sequences of 3.4.17.20

Plasma and recombinant thrombin-activable fibrinolysis inhibitor (TAFI) and activated TAFI compared with respsct to glycosylation, thrombin/thrombomodulin-dependent activation, thermal stability, and enzymatic properties

Boffa, M.B.; Wang, W.; Bajzar, l.; Nesheim, M.E.; J. Biol. Chem. 273, 2127-2135 (1998)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
thrombin
activation
Homo sapiens
Thrombomodulin
activation
Homo sapiens
Cloned(Commentary)
Cloned (Commentary)
Organism
expression in BHK-cells
Homo sapiens
Inhibitors
Inhibitors
Commentary
Organism
Structure
2-Guanidinoethylmercaptosuccinic acid
i.e. GEMSA
Homo sapiens
6-aminohexanoic acid
-
Homo sapiens
potato carboxypeptidase inhibitor
-
Homo sapiens
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
3.41
-
N-[3-(2-Furylacryloyl)]-L-Ala-L-Lys
recombinant enzyme
Homo sapiens
4.71
-
N-[3-(2-Furylacryloyl)]-L-Ala-L-Lys
plasma-derived enzyme
Homo sapiens
766
-
Hippuryl-L-Lys
plasma-derived enzyme
Homo sapiens
783
-
hippuryl-L-Arg
recombinant enzyme
Homo sapiens
817
-
hippuryl-L-Arg
plasma-derived enzyme
Homo sapiens
933
-
Hippuryl-L-Lys
recombinant enzyme
Homo sapiens
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
12000
-
x * 25000 + x * 12000, derived by cleavage at Arg330, inactive form, SDS-PAGE
Homo sapiens
25000
-
x * 25000 + x * 12000, derived by cleavage at Arg330, inactive form, SDS-PAGE
Homo sapiens
35000
-
x * 35000, active enzyme
Homo sapiens
46000
-
x * 46000, enzymes rTAFI and pTAFI, deglycosylated enzymes, slight differences in MW might be due to differences in glycosylation, SDS-PAGE
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
Fibrin, partially degraded + H2O
Homo sapiens
-
?
-
-
?
Organism
Organism
UniProt
Commentary
Textmining
Homo sapiens
-
-
-
Purification (Commentary)
Purification (Commentary)
Organism
of cloned enzyme from BHK-cells
Homo sapiens
Source Tissue
Source Tissue
Commentary
Organism
Textmining
plasma
-
Homo sapiens
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [mol/min/mg]
Specific Activity Maximum [mol/min/mg]
Commentary
Organism
0.017
-
substrate hippuryl-L-Arg
Homo sapiens
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
Fibrin, partially degraded + H2O
-
28933
Homo sapiens
Fibrin, partially degraded + L-Lys + L-Arg
-
28933
Homo sapiens
?
Fibrin, partially degraded + H2O
-
28933
Homo sapiens
?
-
-
-
?
Hippuryl-L-Arg + H2O
-
28933
Homo sapiens
Hippuric acid + L-Arg
-
28933
Homo sapiens
?
Hippuryl-L-Lys + H2O
-
28933
Homo sapiens
Hippuric acid + L-Lys
-
28933
Homo sapiens
?
N-[3-(2-Furylacryloyl)]-L-Ala-L-Lys + H2O
-
28933
Homo sapiens
N-[3-(2-Furylacryloyl)]-L-Ala + L-Lys
-
28933
Homo sapiens
?
Subunits
Subunits
Commentary
Organism
?
derived from zymogen by cleavage at Arg92, SDS-PAGE
Homo sapiens
?
x * 25000 + x * 12000, derived by cleavage at Arg330, inactive form, SDS-PAGE
Homo sapiens
?
x * 46000, enzymes rTAFI and pTAFI, deglycosylated enzymes, slight differences in MW might be due to differences in glycosylation, SDS-PAGE
Homo sapiens
?
x * 35000, active enzyme
Homo sapiens
Temperature Stability [C]
Temperature Stability Minimum [C]
Temperature Stability Maximum [C]
Commentary
Organism
-
-
enzyme pTAFI and rTAFI stable
Homo sapiens
22
-
half-life 120-150 min
Homo sapiens
30
-
half-life 40-50 min
Homo sapiens
37
-
half-life 8-9 min, stable in presence of inhibitors 2-guanidinoethylmercaptosuccinic acid or 6-aminohexanoic acid
Homo sapiens
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
40.7
-
Hippuryl-L-Lys
plasma-derived enzyme
Homo sapiens
45.6
-
Hippuryl-L-Lys
recombinant enzyme
Homo sapiens
52.4
-
hippuryl-L-Arg
plasma-derived enzyme
Homo sapiens
56.7
-
hippuryl-L-Arg
recombinant enzyme
Homo sapiens
248
-
N-[3-(2-Furylacryloyl)]-L-Ala-L-Lys
recombinant enzyme
Homo sapiens
293
-
N-[3-(2-Furylacryloyl)]-L-Ala-L-Lys
plasma-derived enzyme
Homo sapiens
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
thrombin
activation
Homo sapiens
Thrombomodulin
activation
Homo sapiens
Cloned(Commentary) (protein specific)
Commentary
Organism
expression in BHK-cells
Homo sapiens
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
2-Guanidinoethylmercaptosuccinic acid
i.e. GEMSA
Homo sapiens
6-aminohexanoic acid
-
Homo sapiens
potato carboxypeptidase inhibitor
-
Homo sapiens
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
3.41
-
N-[3-(2-Furylacryloyl)]-L-Ala-L-Lys
recombinant enzyme
Homo sapiens
4.71
-
N-[3-(2-Furylacryloyl)]-L-Ala-L-Lys
plasma-derived enzyme
Homo sapiens
766
-
Hippuryl-L-Lys
plasma-derived enzyme
Homo sapiens
783
-
hippuryl-L-Arg
recombinant enzyme
Homo sapiens
817
-
hippuryl-L-Arg
plasma-derived enzyme
Homo sapiens
933
-
Hippuryl-L-Lys
recombinant enzyme
Homo sapiens
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
12000
-
x * 25000 + x * 12000, derived by cleavage at Arg330, inactive form, SDS-PAGE
Homo sapiens
25000
-
x * 25000 + x * 12000, derived by cleavage at Arg330, inactive form, SDS-PAGE
Homo sapiens
35000
-
x * 35000, active enzyme
Homo sapiens
46000
-
x * 46000, enzymes rTAFI and pTAFI, deglycosylated enzymes, slight differences in MW might be due to differences in glycosylation, SDS-PAGE
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
Fibrin, partially degraded + H2O
Homo sapiens
-
?
-
-
?
Purification (Commentary) (protein specific)
Commentary
Organism
of cloned enzyme from BHK-cells
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
plasma
-
Homo sapiens
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [mol/min/mg]
Specific Activity Maximum [mol/min/mg]
Commentary
Organism
0.017
-
substrate hippuryl-L-Arg
Homo sapiens
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
Fibrin, partially degraded + H2O
-
28933
Homo sapiens
Fibrin, partially degraded + L-Lys + L-Arg
-
28933
Homo sapiens
?
Fibrin, partially degraded + H2O
-
28933
Homo sapiens
?
-
-
-
?
Hippuryl-L-Arg + H2O
-
28933
Homo sapiens
Hippuric acid + L-Arg
-
28933
Homo sapiens
?
Hippuryl-L-Lys + H2O
-
28933
Homo sapiens
Hippuric acid + L-Lys
-
28933
Homo sapiens
?
N-[3-(2-Furylacryloyl)]-L-Ala-L-Lys + H2O
-
28933
Homo sapiens
N-[3-(2-Furylacryloyl)]-L-Ala + L-Lys
-
28933
Homo sapiens
?
Subunits (protein specific)
Subunits
Commentary
Organism
?
derived from zymogen by cleavage at Arg92, SDS-PAGE
Homo sapiens
?
x * 25000 + x * 12000, derived by cleavage at Arg330, inactive form, SDS-PAGE
Homo sapiens
?
x * 46000, enzymes rTAFI and pTAFI, deglycosylated enzymes, slight differences in MW might be due to differences in glycosylation, SDS-PAGE
Homo sapiens
?
x * 35000, active enzyme
Homo sapiens
Temperature Stability [C] (protein specific)
Temperature Stability Minimum [C]
Temperature Stability Maximum [C]
Commentary
Organism
-
-
enzyme pTAFI and rTAFI stable
Homo sapiens
22
-
half-life 120-150 min
Homo sapiens
30
-
half-life 40-50 min
Homo sapiens
37
-
half-life 8-9 min, stable in presence of inhibitors 2-guanidinoethylmercaptosuccinic acid or 6-aminohexanoic acid
Homo sapiens
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
40.7
-
Hippuryl-L-Lys
plasma-derived enzyme
Homo sapiens
45.6
-
Hippuryl-L-Lys
recombinant enzyme
Homo sapiens
52.4
-
hippuryl-L-Arg
plasma-derived enzyme
Homo sapiens
56.7
-
hippuryl-L-Arg
recombinant enzyme
Homo sapiens
248
-
N-[3-(2-Furylacryloyl)]-L-Ala-L-Lys
recombinant enzyme
Homo sapiens
293
-
N-[3-(2-Furylacryloyl)]-L-Ala-L-Lys
plasma-derived enzyme
Homo sapiens
Other publictions for EC 3.4.17.20
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
754521
Mertens
Inhibition of the procarboxyp ...
Homo sapiens
J. Thromb. Haemost.
17
878-884
2019
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
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1
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1
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
-
754518
Leenaerts
Carboxypeptidase U (CPU, carb ...
Homo sapiens
J. Thromb. Haemost.
16
2057-2069
2018
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
2
-
-
1
-
4
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
755576
Leenaerts
Plasma carboxypeptidase U (CP ...
Homo sapiens
Thromb. Haemost.
117
1498-1508
2017
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
1
-
3
-
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-
-
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-
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-
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-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
754511
Leenaerts
Plasma levels of carboxypepti ...
Homo sapiens
J. Thromb. Haemost.
13
2227-2232
2015
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
5
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
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-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
707113
Heylen
Development of a sensitive and ...
Homo sapiens
Anal. Biochem.
396
152-154
2010
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
1
-
-
3
-
3
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
1
-
-
3
-
-
-
-
2
-
-
-
-
-
-
-
-
2
2
707122
Heylen
Measurement of carboxypeptidas ...
Homo sapiens
Anal. Biochem.
403
114-116
2010
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
3
-
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-
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-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
707597
Fernandez
Progress in metallocarboxypept ...
Homo sapiens
Biochimie
93
1484-1500
2010
-
-
-
-
-
-
13
-
-
-
1
1
-
3
-
1
-
-
-
2
-
-
1
1
3
-
-
-
-
-
-
-
-
2
-
11
-
-
-
-
-
-
-
11
13
2
-
-
-
1
1
-
-
1
-
-
2
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
709727
Brouns
The decrease in procarboxypept ...
Homo sapiens
J. Thromb. Haemost.
8
75-80
2010
-
1
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
2
-
-
-
-
4
-
-
-
-
-
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-
-
-
-
-
-
1
-
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-
-
-
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-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
696559
Higuchi
Thrombomodulin suppresses inva ...
Homo sapiens
Biol. Pharm. Bull.
32
179-185
2009
-
1
-
-
1
-
-
-
-
-
1
-
-
3
-
-
1
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697399
Matus
Procarboxypeptidase U (TAFI) a ...
Homo sapiens
Clin. Chim. Acta
401
158-161
2009
-
1
-
-
1
-
-
-
-
-
-
-
-
6
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
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-
1
-
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697427
Brouns
Carboxypeptidase U (TAFIa) dec ...
Homo sapiens
Clin. Neurol. Neurosurg.
111
165-170
2009
-
1
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
1
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
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-
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-
-
-
-
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697478
Muto
EF6265, a novel thrombin-activ ...
Rattus norvegicus
Crit. Care Med.
37
1744-1749
2009
-
1
-
-
-
-
1
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
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-
-
-
1
-
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-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697622
Erem
Increased thrombin-activatable ...
Homo sapiens
Endocrine
35
75-80
2009
-
1
-
-
1
-
-
-
-
-
-
-
-
6
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
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-
1
-
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1
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-
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
698151
Ikeda
Presence of thrombin-activatab ...
Homo sapiens
Helicobacter
14
147-155
2009
-
1
-
-
1
-
-
-
-
-
-
-
-
8
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
698377
Cetinkalp
The effect of hormone replacem ...
Homo sapiens
Intern. Med.
48
281-285
2009
-
1
-
-
1
-
-
-
-
-
-
-
-
4
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
699869
Marx
The activation peptide of thro ...
Homo sapiens
J. Thromb. Haemost.
7
445-452
2009
-
1
-
-
2
-
-
-
-
-
-
-
-
1
-
1
1
-
-
-
-
-
1
-
2
1
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
699870
Foley
Soluble thrombomodulin partial ...
Homo sapiens
J. Thromb. Haemost.
7
453-459
2009
1
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
699871
Miah
Functional analysis of mutant ...
Homo sapiens
J. Thromb. Haemost.
7
665-672
2009
3
-
2
-
10
1
-
12
-
-
-
-
-
1
-
-
1
-
-
-
-
-
2
-
2
-
-
-
12
-
-
-
-
-
-
-
3
-
2
-
-
10
1
-
-
-
12
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
12
-
-
-
-
-
-
-
-
-
-
701295
Heylen
Procarboxypeptidase U (TAFI) c ...
Homo sapiens
Thromb. Res.
124
427-432
2009
-
1
-
-
2
-
-
-
-
-
-
-
-
6
-
-
-
-
-
1
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
709725
Willemse
Carboxypeptidase U (TAFIa): a ...
Homo sapiens
J. Thromb. Haemost.
7
1962-1971
2009
3
-
-
-
-
-
13
-
-
-
-
1
-
3
-
-
-
-
-
1
-
-
1
-
3
-
-
-
-
-
-
-
-
-
-
2
3
-
-
-
-
-
-
2
13
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
696925
Nielsen
Clot life span model analysis ...
Homo sapiens
Blood Coagul. Fibrinolysis
19
283-287
2008
-
1
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
696926
Kilicarslan
Fenofibrate improves endotheli ...
Homo sapiens
Blood Coagul. Fibrinolysis
19
310-314
2008
-
1
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
696929
Nielsen
Argatroban enhances fibrinolys ...
Homo sapiens
Blood Coagul. Fibrinolysis
19
793-800
2008
-
1
-
-
-
-
1
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697425
Koldas
Thrombin-activatable fibrinoly ...
Homo sapiens
Clin. Lung Cancer
9
112-115
2008
-
1
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697552
Akinci
Gestational diabetes has no ad ...
Homo sapiens
Diabetes Res. Clin. Pract.
81
93-96
2008
-
1
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697721
Koutroubakis
Plasma thrombin-activatable fi ...
Homo sapiens
Eur. J. Gastroenterol. Hepatol.
20
912-916
2008
-
1
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697791
Erdogan
Thrombin-activatable fibrinoly ...
Homo sapiens
Exp. Clin. Endocrinol. Diabetes
116
143-147
2008
-
1
-
-
1
-
-
-
-
-
-
-
-
4
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
698144
Karakurt
Increased thrombin-activatable ...
Homo sapiens
Gynecol. Endocrinol.
24
491-497
2008
-
1
-
-
1
-
-
-
-
-
-
-
-
4
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
699864
Willemse
Carboxypeptidase U (TAFIa) act ...
Homo sapiens
J. Thromb. Haemost.
6
200-202
2008
-
1
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
1
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
700206
Sanglas
Structure of activated thrombi ...
Homo sapiens, Bos taurus
Mol. Cell
31
598-606
2008
-
-
-
2
-
-
1
2
-
-
-
2
-
4
-
-
2
-
-
2
-
-
4
-
4
2
-
-
2
2
-
-
-
-
-
-
-
-
-
-
2
-
-
-
1
-
2
-
-
-
2
-
-
-
2
-
2
-
-
4
-
2
-
-
2
2
-
-
-
-
-
-
-
-
-
700614
Soni
Antithrombotic effects due to ...
Rattus norvegicus
Pharmacology
82
304-309
2008
-
1
-
-
-
-
-
-
-
-
-
-
-
13
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
701278
Folkeringa
Absolute risk of venous and ar ...
Homo sapiens
Thromb. Haemost.
100
38-44
2008
-
1
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
701280
Bruno
Immune complex-mediated glomer ...
Mus musculus
Thromb. Haemost.
100
90-100
2008
-
1
-
-
1
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667710
Valnickova
Post-translational modificatio ...
Homo sapiens
Biochemistry
45
1525-1535
2006
-
-
-
-
-
1
-
-
-
-
-
-
-
4
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
668287
Willemse
Measurement of procarboxypepti ...
Homo sapiens
Clin. Chem.
52
30-36
2006
-
-
-
-
-
-
-
-
1
-
-
-
-
6
-
1
-
-
-
3
1
-
2
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
3
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
669459
Ceresa
Generation of a stable activat ...
Homo sapiens
J. Biol. Chem.
281
15878-15883
2006
-
-
-
-
1
-
-
-
1
-
-
1
-
4
-
1
-
-
-
1
-
-
2
-
4
1
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
1
-
-
1
-
-
2
-
1
-
2
-
1
-
-
-
-
-
-
-
-
-
670949
Uszynski
Thrombin activatable fibrinoly ...
Homo sapiens
Thromb. Res.
119
241-245
2006
-
-
-
-
-
-
-
-
1
-
-
1
-
4
-
-
-
-
-
4
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
670058
Guimaraes
A new functional assay of thro ...
Homo sapiens
J. Thromb. Haemost.
3
1284-1292
2005
-
-
-
-
-
-
-
-
1
1
-
1
-
3
-
-
-
-
-
2
1
-
1
-
2
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
1
-
-
-
-
-
2
1
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
670059
Marx
Role of isoleucine residues 18 ...
Homo sapiens
J. Thromb. Haemost.
3
1293-1300
2005
-
-
-
-
2
-
-
-
-
1
-
1
-
1
-
1
-
-
-
-
1
-
3
-
5
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
1
-
1
-
-
1
-
-
-
1
-
3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
670060
Willemse
Fast kinetic assay for the det ...
Homo sapiens
J. Thromb. Haemost.
3
2353-2355
2005
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
1
-
-
-
3
1
-
1
-
3
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
3
1
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
670466
Borgstroem
Active carboxypeptidase B is p ...
Homo sapiens
Pancreatology
5
530-536
2005
-
1
-
-
-
-
-
-
1
-
-
-
-
3
-
1
-
-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
670474
Bouma
Thrombin activatable fibrinoly ...
Homo sapiens, Mus musculus
Pathophysiol. Haemost. Thromb.
33
375-381
2005
-
-
-
-
2
2
-
-
2
-
-
4
-
2
-
2
-
-
-
2
-
-
6
-
8
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
-
2
-
-
4
-
-
2
-
-
2
-
-
6
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
670939
Frere
Quantification of thrombin act ...
Homo sapiens
Thromb. Haemost.
94
373-379
2005
-
-
1
-
-
-
-
-
1
-
-
-
-
1
-
-
1
-
-
1
-
-
1
-
2
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
670940
Leurs
Carboxypeptidase U (TAFIa): a ...
Homo sapiens
Thromb. Haemost.
94
471-487
2005
-
-
1
-
3
-
10
-
1
1
-
4
-
4
-
2
1
1
-
7
1
-
7
-
4
-
-
2
-
-
-
-
-
7
-
2
-
-
1
-
-
3
-
2
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7
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1
1
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4
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1
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7
1
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7
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2
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1
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3
1
2
1
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5
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2
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4
5
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1
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1
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1
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3
1
1
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Inhibition of carboxypeptidase ...
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1
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4
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1
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1
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2
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2
1
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2
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1
1
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2
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1
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1
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8
2
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3
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1
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3
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2
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2
2
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2
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2
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2
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Design and synthesis of potent ...
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1
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7
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1
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19
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19
20
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1
1
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1
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1
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-
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-
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-
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668290
Stroemqvist
Properties of recombinant huma ...
Homo sapiens
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2004
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1
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1
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1
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1
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2
1
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5
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1
3
1
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1
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1
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1
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1
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1
1
1
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2
1
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5
-
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-
1
1
-
-
-
1
-
-
-
-
-
-
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668341
Marx
Thrombin-activatable fibrinoly ...
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2
2
11
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2
2
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4
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2
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3
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2
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4
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6
-
10
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2
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3
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2
2
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11
2
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2
2
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4
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3
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4
-
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6
-
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Marx P.
Mechanism of action of carboxy ...
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1
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1
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5
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1
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1
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1
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-
1
-
-
-
-
-
-
-
-
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670291
Matthews
Carboxypeptidase N: a pleiotro ...
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2004
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1
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4
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1
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1
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1
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1
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3
-
-
-
-
-
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-
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-
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670892
Bouma
New insights into factors affe ...
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2004
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1
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1
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5
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1
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1
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1
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-
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-
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-
-
-
-
-
-
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670931
Mousa
Thrombin activatable fibrinoly ...
Homo sapiens
Thromb. Haemost.
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2004
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-
-
-
-
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1
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1
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3
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1
1
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1
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2
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1
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1
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1
1
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1
-
-
-
-
-
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-
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-
-
-
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649320
Mao
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5
5
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1
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1
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5
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4
5
1
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5
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5
5
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1
-
-
-
-
1
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-
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647563
Kawamura
Elastase from activated human ...
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1
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1
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1
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1
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1
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1
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-
1
-
-
-
-
-
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-
-
-
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650827
Lazoura
Rational structure-based desig ...
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3
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1
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2
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-
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3
2
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-
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-
-
-
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-
1
-
-
-
-
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652361
Schneider
Amino acid residues in the P6- ...
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2
1
1
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16
5
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-
-
-
-
-
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-
-
1
-
-
3
-
-
-
-
4
-
-
1
1
-
-
4
1
-
-
-
-
2
1
-
-
16
5
-
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653144
Campbell
Inactivation of C3a and C5a oc ...
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2002
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1
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3
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2
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1
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-
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3
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-
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653145
Komura
Heat stability of carboxypepti ...
Cavia porcellus, Oryctolagus cuniculus, Homo sapiens, Rattus norvegicus
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2002
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4
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8
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4
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4
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4
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8
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653977
Bouma
Thrombin-activatable fibrinoly ...
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3
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1
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3
1
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1
1
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1
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10
3
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1
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1
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2
1
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9
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Marx
Inactivation of active thrombi ...
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2
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1
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-
1
1
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1
1
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1
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1
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2
1
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1
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1
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2
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653143
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Molecular cloning and partial ...
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1
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1
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1
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28932
Bajazar
Both cellular and soluble form ...
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1
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28933
Boffa
Plasma and recombinant thrombi ...
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28934
Kokame
Activation of thrombin-activab ...
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28935
Cote
Functional characterization of ...
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28936
Sakharov
On the mechanism of the antifi ...
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1
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28937
Nesheim
Thrombin, thrombomodulin and T ...
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1
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28938
Von dem Borne
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28939
Broze
Thrombin-dependent inhibition ...
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-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
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-
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-
28940
Bajzar
TAFI, or plasma procarboxypept ...
Homo sapiens
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16603-16608
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2
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-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
28941
Broze
Coagulation-dependent inhibiti ...
Homo sapiens
Blood
88
3815-3823
1996
2
-
-
-
-
-
-
-
-
-
1
1
-
1
-
-
1
-
-
1
-
1
2
2
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
1
-
1
-
1
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
28942
Tan
Activation and characterizatio ...
Homo sapiens
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34
5811-5816
1995
-
-
-
-
-
1
-
10
-
1
-
-
-
4
-
-
-
-
-
2
1
-
10
-
-
-
-
-
10
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
10
-
1
-
-
-
-
-
-
-
2
1
-
10
-
-
-
-
10
2
-
-
-
-
-
-
-
-
-
28943
Bajzar
Purification and characterizat ...
Homo sapiens
J. Biol. Chem.
270
14477-14484
1995
1
-
-
-
-
-
1
-
-
-
3
1
-
2
-
-
1
-
-
1
1
-
1
3
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
3
1
-
-
-
1
-
1
1
-
1
3
-
-
-
-
-
-
-
-
-
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-
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-
-
28944
Wang
Carboxypeptidase U, a plasma c ...
Homo sapiens
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269
15937-15944
1994
-
-
-
-
-
1
2
2
-
1
2
-
-
3
-
-
1
-
-
1
1
-
3
1
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
2
-
1
2
-
-
-
-
1
-
1
1
-
3
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
28945
Eaton
Isolation, molecular cloning, ...
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1
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5
-
-
-
-
-
1
2
-
3
1
-
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-
-
-
-
-
-
-
-
-
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-
-
1
-
-
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-
-
-
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-
-
-
-
-
-
-
1
2
-
3
1
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