Crystallization (Comment) | Organism |
---|---|
crystal structure at 1.6 A resolution of PBP5 in complex with a substrate-like peptide boronic acid, suggesting a hydrogen-bonding network, involving Lys-213, Ser-110, and a bridging water molecule, to polarize the hydrolytic water molecule | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Boc-gamma-D-Glu-L-Lys-(Cbz)-D-boroAla-(-)-pinanediol | effective inhibitor of the D-alanine CPase activity of PBP5 | Escherichia coli |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
6.4 | - |
Boc-gamma-D-Glu-L-Lys-(Cbz)-D-Ala-D-Ala | - |
Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | P0AEB2 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Boc-gamma-D-Glu-L-Lys-(Cbz)-D-Ala-D-Ala | - |
Escherichia coli | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
D-alanine-carboxypeptidase | - |
Escherichia coli |
PBP5 | - |
Escherichia coli |
penicillin-binding protein 5 | - |
Escherichia coli |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.013 | - |
Boc-gamma-D-Glu-L-Lys-(Cbz)-D-boroAla-(-)-pinanediol | - |
Escherichia coli |