Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
molecular dynamics simulations of the complex with luteolin. The 3' and 4' hydroxyl group on B-ring as well as 5 and 7 hydroxyl group on A-ring helps luteolin to interact with the Asn391, Asn406, Tyr417, His450, Glu451, Val447, Glu512, Asn545, Gln566, and Arg572 residues | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
fisetin | - |
Homo sapiens | |
galangin | - |
Homo sapiens | |
genistein | - |
Homo sapiens | |
kaempferol | - |
Homo sapiens | |
luteolin | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9NY33 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Arg-Arg-2-naphthylamide + H2O | - |
Homo sapiens | Arg-Arg + 2-naphthylamine | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.022 | - |
pH 7.4, 37°C | Homo sapiens | luteolin | |
0.0234 | - |
pH 7.4, 37°C | Homo sapiens | galangin | |
0.0249 | - |
pH 7.4, 37°C | Homo sapiens | fisetin | |
0.0329 | - |
pH 7.4, 37°C | Homo sapiens | kaempferol | |
0.0366 | - |
pH 7.4, 37°C | Homo sapiens | genistein |