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Ala-Ala-2-naphthylamide + H2O
Ala-Ala + 2-naphthylamine
Ala-Ala-2-naphthylamide + H2O
Ala-Ala + 2-naphtylamine
Substrates: assay at 37°C, pH 8.0
Products: -
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Ala-Ala-2-naphtylamide + H2O
Ala-Ala + 2-naphthylamine
Ala-Ala-Ala-Ala + H2O
Ala-Ala + Ala-Ala
-
Substrates: action of goat brain DPP-III on the peptide is investigated, substrate is hydrolyzed
Products: -
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Ala-Ala-beta-naphthylamide + H2O
Ala-Ala + beta-naphthylamine
-
Substrates: 10.0% activity
Products: -
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Ala-Arg-2-naphthylamide + H2O
Ala-Arg + 2-naphthylamine
Ala-Arg-2-naphtylamide + H2O
Ala-Arg + 2-naphthylamine
Ala-Phe-2-naphthylamide + H2O
Ala-Phe + 2-naphthylamine
Substrates: -
Products: -
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Ala-Phe-2-naphthylamide + H2O
Ala-Phe + 2-naphtylamine
Substrates: assay at 37°C, pH 8.0
Products: -
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angiotensin II + H2O
Asp-Arg + Val-Tyr + Ile-His + Pro-Phe
Arg-Arg-2-naphthylamide + H2O
Arg-Arg + 2-naphthylamine
Arg-Arg-2-naphtylamide + H2O
Arg-Arg + 2-naphthylamine
Arg-Arg-4-methoxy-2-naphthylamide + H2O
Arg-Arg + 4-methoxy-2-naphthylamine
Arg-Arg-4-methoxy-beta-naphthylamide + H2O
Arg-Arg + 4-methoxy-beta-naphthylamine
-
Substrates: activity assay, 100% activity
Products: -
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Arg-Arg-4-methylcoumarin 7-amide + H2O
Arg-Arg + 7-amino-4-methylcoumarin
Substrates: -
Products: -
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Arg-Arg-7-amido-4 methylcoumarin + H2O
?
-
Substrates: -
Products: -
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Arg-Arg-7-amido-4-methylcoumarin + H2O
Arg-Arg + 7-amino-4-methylcoumarin
-
Substrates: assay at 37°C
Products: -
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Arg-Arg-beta-naphthylamide + H2O
Arg-Arg + beta-naphthylamine
-
Substrates: -
Products: -
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Arg-Arg-naphthylamide + H2O
?
-
Substrates: substrate used in the activity assay
Products: -
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Arg-Tyr-Leu-Pro-Thr + H2O
Arg-Tyr + Leu-Pro-Thr
Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu + H2O
?
-
Substrates: angiotensin III, action of goat brain DPP-III on the peptide is investigated, substrate is hydrolyzed
Products: -
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arginyl-arginyl-4-methoxy-beta-naphthylamide + H2O
Arg-Arg + 4-methoxy-beta-naphthylamine
-
Substrates: substrate used in the activity assay
Products: -
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Asp-Ala-beta-naphthylamide + H2O
Asp-Ala + beta-naphthylamine
-
Substrates: 0% activity
Products: -
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Asp-Arg-beta-naphthylamide + H2O
Asp-Arg + beta-naphthylamine
-
Substrates: 1.5% activity
Products: -
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Asp-Arg-Val-Tyr-Ile-His-Pro-Phe + H2O
?
-
Substrates: angiotensin II, action of goat brain DPP-III on the peptide is investigated, substrate is hydrolyzed
Products: -
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DRVYIHPF + H2O
IHPF + ?
Substrates: i.e. angiotensin II
Products: -
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enkephalin + H2O
?
-
Substrates: -
Products: -
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Gly-Ala-beta-naphthylamide + H2O
Gly-Ala + beta-naphthylamine
-
Substrates: 3.2% activity
Products: -
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Gly-Arg-2-naphthylamide + H2O
Gly-Arg + 2-naphthylamine
Substrates: -
Products: -
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Gly-Arg-2-naphtylamide + H2O
Gly-Arg + 2-naphthylamine
Gly-Arg-beta-naphthylamide + H2O
Gly-Arg + beta-naphthylamine
Gly-Gly-Phe-Leu + H2O
?
-
Substrates: -
Products: -
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Gly-Phe-2-naphthylamide + H2O
Gly-Phe + 2-naphthylamine
Substrates: assay at 37°C, pH 8.0
Products: -
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Gly-Phe-beta-naphthylamide + H2O
Gly-Phe + beta-naphthylamine
-
Substrates: 2.4% activity
Products: -
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Gly-Pro-4-methoxy-beta-naphthylamide + H2O
Gly-Pro + 4-methoxy-beta-naphthylamine
-
Substrates: 0% activity
Products: -
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His-Phe-beta-naphthylamide + H2O
His-Phe + beta-naphthylamine
-
Substrates: 0% activity
Products: -
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His-Ser-2-naphthylamide + H2O
His-Ser + 2-naphthylamine
Substrates: -
Products: -
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His-Ser-beta-naphthylamide + H2O
His-Ser + beta-naphthylamine
-
Substrates: 0% activity
Products: -
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IVYPW + H2O
YPW + ?
Substrates: -
Products: -
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L-Ala-L-Ala 2-naphthylamide + H2O
L-Ala-L-Ala + 2-naphthylamine
Substrates: -
Products: -
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L-Ala-L-Ala-2-naphthylamide + H2O
L-Ala-L-Ala + 2-naphthylamine
-
Substrates: 36.64% of the activiy with L-Arg-L-Arg-4-methoxy-2-naphthylamide
Products: -
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L-Arg-L-Arg 2-naphthylamide + H2O
L-Arg-L-Arg + 2-naphthylamine
Substrates: -
Products: -
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L-Arg-L-Arg-2-naphthylamide + H2O
L-Arg-L-Arg + 2-naphthylamine
L-Arg-L-Arg-4-methoxy-2-naphthylamide + H2O
L-Arg-L-Arg + 4-methoxy-2-naphthylamine
L-Asp-L-Ala-2-naphthylamide + H2O
L-Asp-L-Ala + 2-naphthylamine
-
Substrates: 8.67% of the activiy with L-Arg-L-Arg-4-methoxy-2-naphthylamide
Products: -
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L-Asp-L-Arg-2-naphthylamide + H2O
L-Asp-L-Arg + 2-naphthylamine
-
Substrates: 9.8% of the activiy with L-Arg-L-Arg-4-methoxy-2-naphthylamide
Products: -
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L-His-L-Ser-4-methoxy-2-naphthylamide + H2O
L-His-L-Ser + 4-methoxy-2-naphthylamine
-
Substrates: 58.46% of the activiy with L-Arg-L-Arg-4-methoxy-2-naphthylamide
Products: -
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L-Lys-L-Ala-2-naphthylamide + H2O
L-Lys-L-Ala + 2-naphthylamine
-
Substrates: activity of the cupric derivative for Lys-Ala-beta-naphthylamide is about 30% of that of the wild-type enzyme
Products: -
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L-Ser-L-Tyr-2-naphthylamide + H2O
L-Ser-L-Tyr + 2-naphthylamine
-
Substrates: 7.35% of the activiy with L-Arg-L-Arg-4-methoxy-2-naphthylamide
Products: -
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Leu-Ala-beta-naphthylamide + H2O
Leu-Ala + beta-naphthylamine
-
Substrates: 5.0% activity
Products: -
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Leu-enkephalin + H2O
Tyr-Gly + Gly-Phe-Leu
Leu-Gly-2-naphthylamide + H2O
Leu-Gly + 2-naphthylamine
Lys-Ala-2-naphthylamide + H2O
Lys-Ala + 2-naphthylamine
Lys-Ala-4-methoxy-2-naphthylamide + H2O
Lys-Ala + 4-methoxy-2-naphthylamine
Lys-Ala-4-methoxy-beta-naphthylamide + H2O
Lys-Ala + 4-methoxy-beta-naphthylamine
-
Substrates: 5.0% activity
Products: -
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Lys-Arg-2-naphtylamide + H2O
Lys-Arg + 2-naphthylamine
-
Substrates: -
Products: -
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Lys-Arg-beta-naphthylamide + H2O
Lys-Arg + beta-naphthylamine
-
Substrates: 8% of the activity with Arg-Arg-beta-naphthylamide
Products: -
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Met-Arg-Phe-Ala + H2O
Met-Arg + Phe-Ala
-
Substrates: -
Products: -
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Met-enkephalin + H2O
?
-
Substrates: -
Products: -
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Phe-Arg-2-naphthylamide + H2O
Phe-Arg + 2-naphthylamine
Phe-Arg-2-naphtylamide + H2O
Phe-Arg + 2-naphthylamine
Phe-Arg-beta-naphthylamide + H2O
Phe-Arg + beta-naphthylamine
-
Substrates: 17.6% activity
Products: -
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Pro-Arg-2-naphthylamide + H2O
Pro-Arg + 2-naphthylamine
Pro-Arg-2-naphtylamide + H2O
Pro-Arg + 2-naphthylamine
Substrates: 143% of the activity with Arg-Arg-2-naphtylamide
Products: -
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proctolin + H2O
Arg-Tyr + Leu-Pro-Thr
Substrates: -
Products: -
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proctolin + H2O
Tyr-Leu + ?
-
Substrates: -
Products: -
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Ser-Met-beta-naphthylamide + H2O
Ser-Met + beta-naphthylamine
-
Substrates: 0% activity
Products: -
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Ser-Tyr-beta-naphthylamide + H2O
Ser-Tyr + beta-naphthylamine
-
Substrates: 0% activity
Products: -
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Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly + H2O
?
-
Substrates: ACTH, action of goat brain DPP-III on the peptide is investigated, substrate is hydrolyzed
Products: -
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Trp-Met-Asp-Phe-NH2 + H2O
?
-
Substrates: -
Products: -
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Trp-Met-Asp-Phe-NH2 + H2O
Trp-Met + Asp-Phe-NH2
-
Substrates: gastrin tetrapeptide amide, action of goat brain DPP-III on the peptide is investigated, substrate is hydrolyzed
Products: -
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Tyr-Gly-Gly-Phe + H2O
Tyr-Gly + Gly-Phe
Tyr-Gly-Gly-Phe-Leu + H2O
Tyr-Gly + Gly-Phe-Leu
Tyr-Gly-Gly-Phe-Met + H2O
?
Substrates: -
Products: -
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Tyr-Pro-Trp-Phe-NH2 + H2O
Tyr-Pro + Trp-Phe-NH2
-
Substrates: endomorphin-1
Products: -
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VVYPW + H2O
YPW + ?
Substrates: i.e. tynorphin
Products: -
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additional information
?
-
Ala-Ala-2-naphthylamide + H2O
Ala-Ala + 2-naphthylamine
Substrates: -
Products: -
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Ala-Ala-2-naphthylamide + H2O
Ala-Ala + 2-naphthylamine
-
Substrates: -
Products: -
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Ala-Ala-2-naphthylamide + H2O
Ala-Ala + 2-naphthylamine
-
Substrates: poor substrate
Products: -
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Ala-Ala-2-naphthylamide + H2O
Ala-Ala + 2-naphthylamine
Substrates: -
Products: -
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Ala-Ala-2-naphthylamide + H2O
Ala-Ala + 2-naphthylamine
-
Substrates: poor substrate
Products: -
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Ala-Ala-2-naphthylamide + H2O
Ala-Ala + 2-naphthylamine
-
Substrates: -
Products: -
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Ala-Ala-2-naphthylamide + H2O
Ala-Ala + 2-naphthylamine
Substrates: -
Products: -
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Ala-Ala-2-naphtylamide + H2O
Ala-Ala + 2-naphthylamine
Substrates: 103% of the activity with Arg-Arg-2-naphtylamide
Products: -
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Ala-Ala-2-naphtylamide + H2O
Ala-Ala + 2-naphthylamine
Substrates: 103% of the activity with Arg-Arg-2-naphtylamide
Products: -
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Ala-Arg-2-naphthylamide + H2O
Ala-Arg + 2-naphthylamine
Substrates: -
Products: -
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Ala-Arg-2-naphthylamide + H2O
Ala-Arg + 2-naphthylamine
-
Substrates: -
Products: -
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Ala-Arg-2-naphthylamide + H2O
Ala-Arg + 2-naphthylamine
Substrates: poor substrate
Products: -
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Ala-Arg-2-naphthylamide + H2O
Ala-Arg + 2-naphthylamine
Substrates: -
Products: -
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Ala-Arg-2-naphthylamide + H2O
Ala-Arg + 2-naphthylamine
Substrates: -
Products: -
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Ala-Arg-2-naphthylamide + H2O
Ala-Arg + 2-naphthylamine
-
Substrates: -
Products: -
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Ala-Arg-2-naphtylamide + H2O
Ala-Arg + 2-naphthylamine
Substrates: 65% of the activity with Arg-Arg-2-naphtylamide
Products: -
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Ala-Arg-2-naphtylamide + H2O
Ala-Arg + 2-naphthylamine
Substrates: 65% of the activity with Arg-Arg-2-naphtylamide
Products: -
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angiotensin II + H2O
Asp-Arg + Val-Tyr + Ile-His + Pro-Phe
-
Substrates: -
Products: -
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angiotensin II + H2O
Asp-Arg + Val-Tyr + Ile-His + Pro-Phe
-
Substrates: -
Products: -
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angiotensin II + H2O
Asp-Arg + Val-Tyr + Ile-His + Pro-Phe
-
Substrates: -
Products: -
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angiotensin II + H2O
Asp-Arg + Val-Tyr + Ile-His + Pro-Phe
-
Substrates: -
Products: -
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Arg-Arg-2-naphthylamide + H2O
Arg-Arg + 2-naphthylamine
Substrates: -
Products: -
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Arg-Arg-2-naphthylamide + H2O
Arg-Arg + 2-naphthylamine
-
Substrates: -
Products: -
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Arg-Arg-2-naphthylamide + H2O
Arg-Arg + 2-naphthylamine
Substrates: -
Products: -
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Arg-Arg-2-naphthylamide + H2O
Arg-Arg + 2-naphthylamine
Substrates: -
Products: -
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Arg-Arg-2-naphthylamide + H2O
Arg-Arg + 2-naphthylamine
-
Substrates: -
Products: -
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Arg-Arg-2-naphthylamide + H2O
Arg-Arg + 2-naphthylamine
-
Substrates: -
Products: -
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Arg-Arg-2-naphthylamide + H2O
Arg-Arg + 2-naphthylamine
Substrates: -
Products: -
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Arg-Arg-2-naphthylamide + H2O
Arg-Arg + 2-naphthylamine
-
Substrates: -
Products: -
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Arg-Arg-2-naphthylamide + H2O
Arg-Arg + 2-naphthylamine
Substrates: -
Products: -
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Arg-Arg-2-naphthylamide + H2O
Arg-Arg + 2-naphthylamine
Substrates: preferred substrate
Products: -
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Arg-Arg-2-naphthylamide + H2O
Arg-Arg + 2-naphthylamine
-
Substrates: substrate used in the activity assay
Products: -
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Arg-Arg-2-naphthylamide + H2O
Arg-Arg + 2-naphthylamine
Substrates: substrate used in the activity assay
Products: -
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Arg-Arg-2-naphthylamide + H2O
Arg-Arg + 2-naphthylamine
Substrates: assay at 37°C, pH 8.0
Products: -
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Arg-Arg-2-naphthylamide + H2O
Arg-Arg + 2-naphthylamine
Substrates: -
Products: -
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Arg-Arg-2-naphthylamide + H2O
Arg-Arg + 2-naphthylamine
Substrates: -
Products: -
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Arg-Arg-2-naphthylamide + H2O
Arg-Arg + 2-naphthylamine
-
Substrates: -
Products: -
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Arg-Arg-2-naphthylamide + H2O
Arg-Arg + 2-naphthylamine
-
Substrates: -
Products: -
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Arg-Arg-2-naphthylamide + H2O
Arg-Arg + 2-naphthylamine
Substrates: assay at pH 8.0, 37°C
Products: -
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Arg-Arg-2-naphthylamide + H2O
Arg-Arg + 2-naphthylamine
Schistosoma sp.
-
Substrates: -
Products: -
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Arg-Arg-2-naphthylamide + H2O
Arg-Arg + 2-naphthylamine
-
Substrates: -
Products: -
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Arg-Arg-2-naphtylamide + H2O
Arg-Arg + 2-naphthylamine
Substrates: -
Products: -
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Arg-Arg-2-naphtylamide + H2O
Arg-Arg + 2-naphthylamine
Substrates: -
Products: -
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Arg-Arg-4-methoxy-2-naphthylamide + H2O
Arg-Arg + 4-methoxy-2-naphthylamine
-
Substrates: -
Products: -
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Arg-Arg-4-methoxy-2-naphthylamide + H2O
Arg-Arg + 4-methoxy-2-naphthylamine
-
Substrates: -
Products: -
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Arg-Arg-4-methoxy-2-naphthylamide + H2O
Arg-Arg + 4-methoxy-2-naphthylamine
-
Substrates: -
Products: -
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Arg-Tyr-Leu-Pro-Thr + H2O
Arg-Tyr + Leu-Pro-Thr
-
Substrates: -
Products: -
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Arg-Tyr-Leu-Pro-Thr + H2O
Arg-Tyr + Leu-Pro-Thr
Substrates: -
Products: -
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Arg-Tyr-Leu-Pro-Thr + H2O
Arg-Tyr + Leu-Pro-Thr
-
Substrates: i.e. proctolin
Products: -
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Gly-Arg-2-naphtylamide + H2O
Gly-Arg + 2-naphthylamine
Substrates: 167% of the activity with Arg-Arg-2-naphtylamide
Products: -
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Gly-Arg-2-naphtylamide + H2O
Gly-Arg + 2-naphthylamine
Substrates: 167% of the activity with Arg-Arg-2-naphtylamide
Products: -
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Gly-Arg-beta-naphthylamide + H2O
Gly-Arg + beta-naphthylamine
-
Substrates: 11.8% activity
Products: -
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Gly-Arg-beta-naphthylamide + H2O
Gly-Arg + beta-naphthylamine
-
Substrates: 6.1% of the activity with Arg-Arg-beta-naphthylamide
Products: -
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L-Arg-L-Arg-2-naphthylamide + H2O
L-Arg-L-Arg + 2-naphthylamine
Substrates: binding free energy calculations reveal tighter binding of the preferred synthetic substrate Arg-Arg-2-naphtylamide to the closed than to the open enzyme conformation. The electrostatic component of the free energy of solvation is higher for the closed protein than for its less compact form
Products: -
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L-Arg-L-Arg-2-naphthylamide + H2O
L-Arg-L-Arg + 2-naphthylamine
-
Substrates: -
Products: -
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L-Arg-L-Arg-4-methoxy-2-naphthylamide + H2O
L-Arg-L-Arg + 4-methoxy-2-naphthylamine
-
Substrates: -
Products: -
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L-Arg-L-Arg-4-methoxy-2-naphthylamide + H2O
L-Arg-L-Arg + 4-methoxy-2-naphthylamine
-
Substrates: -
Products: -
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Leu-enkephalin + H2O
Tyr-Gly + Gly-Phe-Leu
-
Substrates: -
Products: -
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Leu-enkephalin + H2O
Tyr-Gly + Gly-Phe-Leu
-
Substrates: -
Products: -
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Leu-enkephalin + H2O
Tyr-Gly + Gly-Phe-Leu
-
Substrates: -
Products: -
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Leu-Gly-2-naphthylamide + H2O
Leu-Gly + 2-naphthylamine
-
Substrates: no reaction
Products: -
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Leu-Gly-2-naphthylamide + H2O
Leu-Gly + 2-naphthylamine
-
Substrates: -
Products: -
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Leu-Gly-2-naphthylamide + H2O
Leu-Gly + 2-naphthylamine
-
Substrates: -
Products: -
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Lys-Ala-2-naphthylamide + H2O
Lys-Ala + 2-naphthylamine
-
Substrates: -
Products: -
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Lys-Ala-2-naphthylamide + H2O
Lys-Ala + 2-naphthylamine
-
Substrates: -
Products: -
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Lys-Ala-4-methoxy-2-naphthylamide + H2O
Lys-Ala + 4-methoxy-2-naphthylamine
-
Substrates: poor substrate
Products: -
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Lys-Ala-4-methoxy-2-naphthylamide + H2O
Lys-Ala + 4-methoxy-2-naphthylamine
-
Substrates: -
Products: -
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Lys-Ala-4-methoxy-2-naphthylamide + H2O
Lys-Ala + 4-methoxy-2-naphthylamine
-
Substrates: poor substrate
Products: -
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Phe-Arg-2-naphthylamide + H2O
Phe-Arg + 2-naphthylamine
Substrates: poor substrate
Products: -
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Phe-Arg-2-naphthylamide + H2O
Phe-Arg + 2-naphthylamine
Substrates: -
Products: -
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Phe-Arg-2-naphthylamide + H2O
Phe-Arg + 2-naphthylamine
Substrates: -
Products: -
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Phe-Arg-2-naphtylamide + H2O
Phe-Arg + 2-naphthylamine
Substrates: 129% of the activity with Arg-Arg-2-naphtylamide
Products: -
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Phe-Arg-2-naphtylamide + H2O
Phe-Arg + 2-naphthylamine
Substrates: 129% of the activity with Arg-Arg-2-naphtylamide
Products: -
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Pro-Arg-2-naphthylamide + H2O
Pro-Arg + 2-naphthylamine
Substrates: -
Products: -
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Pro-Arg-2-naphthylamide + H2O
Pro-Arg + 2-naphthylamine
Substrates: -
Products: -
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Tyr-Gly-Gly-Phe + H2O
Tyr-Gly + Gly-Phe
-
Substrates: enkephalin, action of goat brain DPP-III on the peptide is investigated, substrate is hydrolyzed
Products: -
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Tyr-Gly-Gly-Phe + H2O
Tyr-Gly + Gly-Phe
-
Substrates: -
Products: -
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Tyr-Gly-Gly-Phe-Leu + H2O
Tyr-Gly + Gly-Phe-Leu
-
Substrates: Leu-enkephalin, action of goat brain DPP-III on the peptide is investigated, substrate is hydrolyzed
Products: -
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Tyr-Gly-Gly-Phe-Leu + H2O
Tyr-Gly + Gly-Phe-Leu
-
Substrates: -
Products: -
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additional information
?
-
Substrates: enzyme additionally hydrolyzes isopentenyl diphosphate and dephosphorylates purine nucleotides ADP, dGDP, dGTP, and 8-oxo-dATP with strong preference for oxidized dATP
Products: -
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additional information
?
-
-
Substrates: enzyme additionally hydrolyzes isopentenyl diphosphate and dephosphorylates purine nucleotides ADP, dGDP, dGTP, and 8-oxo-dATP with strong preference for oxidized dATP
Products: -
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additional information
?
-
-
Substrates: polypeptides having unsubstituted N-termini, Gly4, Glu4, tripeptides and bonds involving proline are resistant
Products: -
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additional information
?
-
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Substrates: polypeptides having unsubstituted N-termini, Gly4, Glu4, tripeptides and bonds involving proline are resistant
Products: -
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additional information
?
-
-
Substrates: Ala-Ala-Ala, action of goat brain DPP-III on the peptide is investigated, substrate is not hydrolyzed
Products: no activity
?
additional information
?
-
-
Substrates: Gly-Phe-Leu, action of goat brain DPP-III on the peptide is investigated, substrate is not hydrolyzed
Products: no activity
?
additional information
?
-
-
Substrates: -
Products: -
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additional information
?
-
-
Substrates: hydrolysis depending on type of amino acid and chain length
Products: -
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additional information
?
-
-
Substrates: enzyme prefers a hydrophobic residue at P1 position
Products: -
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additional information
?
-
-
Substrates: no substrates: Arg-4-methyl-beta-naphthylamide, Ser-beta-naphthylamide, Leu-beta-naphthylamide, Pro-beta-naphthylamide, Val-beta-naphthylamide, Asp-beta-naphthylamide, Ile-beta-naphthylamide, Phe-beta-naphthylamide, Tyr-beta-naphthylamide, Trp-beta-naphthylamide, Gly-beta-naphthylamide, Arg-Phe-Ala-beta-naphthylamide, Gly-Pro-Leu-beta-naphthylamide, benzyloxycarbonyl-Phe-Arg-4-methyl-beta-naphthylamide, N-benzoyl-DL-Arg-beta-naphthylamide
Products: -
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additional information
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-
Substrates: enzyme additionally hydrolyzes isopentenyl diphosphate and dephosphorylates purine nucleotides ADP, dGDP, dGTP, and 8-oxo-dATP with strong preference for oxidized dATP
Products: -
?
additional information
?
-
-
Substrates: enzyme additionally hydrolyzes isopentenyl diphosphate and dephosphorylates purine nucleotides ADP, dGDP, dGTP, and 8-oxo-dATP with strong preference for oxidized dATP
Products: -
?
additional information
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-
-
Substrates: -
Products: -
?
additional information
?
-
-
Substrates: hydrolysis depending on type of amino acid and chain length
Products: -
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additional information
?
-
-
Substrates: hydrolysis depending on type of amino acid and chain length
Products: -
?
additional information
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-
-
Substrates: enzyme prefers a hydrophobic residue at P1 position
Products: -
?
additional information
?
-
-
Substrates: no or very poor substrates: Gly-Phe-naphthylamide, Leu-Ala-2-naphthylamide, Ser-Met-2-naphthylamide, Gly-Ala-2-naphthylamide, Phe-Arg-2-naphthylamide, His-Phe-naphthylamide, Arg-4-methoxy-2-naphthylamide, Ser-2-naphthylamide, Leu-2-naphthylamide, Pro-2-naphthylamide, Val-2-naphthylamide, M-Gly-Arg-2-naphthylamide, Gly-Pro-Leu-2-naphthylamide, Val-Lys-Lys-Arg-4-methoxy-2-naphthylamide, benzoyl-DL-Arg-2-naphthylamide, Z-Arg-Arg-4-methoxy-2-naphthylamide
Products: -
?
additional information
additional information
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-
Substrates: Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu, angiotensin I, action of goat brain DPP-III on the peptide is investigated, substrate is not hydrolyzed
Products: no activity
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1,3-di-[5-(2-imidazolinyl)-2-benzimidazolyl]-2,4-di-o-chlorophenyl-cyclobutane dihydrochloride
-
-
1,3-di-[5-(2-imidazolinyl)-2-benzimidazolyl]-2,4-di-phenyl-cyclobutane dihydrochloride
-
-
1,3-di-[5-(2-imidazolinyl)-2-benzoimidazolyl]-2,4-di-(2-furyl)-cyclobutane dihydrochloride
-
-
1,3-di-[5-(2-imidazolinyl)-2-benzoimidazolyl]-2,4-di-(2-thienyl)-cyclobutane dihydrochloride
-
-
1,3-di-[5-(2-imidazolinyl)-2-benzoimidazolyl]-2,4-di-(2-thienyl)-cyclobutanedihydrochloride
-
-
1,3-di-[5-(N-amidino)-2-benzimidazolyl]-2,4-di-o-chlorophenyl-cyclobutane dihydrochloride
-
-
1,3-di-[5-(N-amidino)-2-benzimidazolyl]-2,4-di-phenyl-cyclobutane dihydrochloride
-
-
1,3-di-[5-(N-isopropylamidino)-2-benzimidazolyl]-2,4-di-o-chlorophenyl-cyclobutane dihydrochloride
-
-
1,3-di-[5-(N-isopropylamidino)-2-benzimidazolyl]-2,4-di-o-chlorophenylcyclobutane dihydrochloride
-
-
1,3-di-[5-(N-isopropylamidino)-2-benzimidazolyl]-2,4-di-phenyl-cyclobutane dihydrochloride
-
-
1-ethyl-3(3-dimethyl-amino-propyl)-carbodiimide*HCl
-
1.0 mM inhibitor, 29% inhibition, 5.0 mM inhibitor, 64% inhibition
2,2'-dithiodipyridine
-
1.0 mM inhibitor, 32% inhibition, 2.5 mM inhibitor, 98% inhibition
2,4,6-trinitrobenzene sufonic acid trihydrate
-
1.0 mM inhibitor, 52% inhibition, 2.5 mM inhibitor, 89% inhibition
2-(3H-imidazol-4-yl)-1H-benzoimidazole-5-carboxamidine hydrochloride
-
complete inhibition at 0.1 mM
2-(3H-imidazol-4-yl)-1H-benzoimidazole-5-imidazolinylamidine hydrochloride
-
complete inhibition at 0.1 mM
2-[(E)-2-phenylethenyl]-1H-benzimidazole
-
-
3,3'-dithiobis(6-nitrobenzoic acid)
-
13% residual activity at 2.5 mM, beta-mercaptoethanol and dithiothreitlol completely restores enzyme activity
4,4'-dithiodipyridine
inactivation of wild-type dipeptidyl peptidase III after incubation at pH 8.0 at 25°C, after 5 min incubation loss of 30% enzyme activity, after 15 min incubation loss of 62% enzyme activity
4-(2-aminoethyl) benzenesulfonyl fluoride
-
0.01 mM, 89% inhibition
4-Chlorobenzoic acid
-
0.5 mM, 42% inhibition
4-nitrophenyl iodoacetate
-
0.5 mM, 57% inhibition
5,5'-dithiobis(2-nitrobenzoate)
6-(4,5-dihydro-1H-imidazol-2-yl)-2-[(E)-2-phenylethenyl]-1H-benzimidazole
Acetyl-L-Leu-L-arginal
-
-
AEBSF
-
0.2 mM, 84% inhibition
alpha1 anti-trypsin
-
1.0 mM inhibitor, 61% inhibition
-
amastatin
-
30% inhibition at 0.1 mM
amino([(5-([(2R)-1-methoxy-3-(6-methylphenanthridin-8-yl)-1-oxopropan-2-yl]carbamoyl)-1H-pyrrol-2-yl)carbonyl]amino)methaniminium chloride
0.035 mM, 45% inhibition
amino[((5-[(2-([(2R)-1-methoxy-3-(6-methylphenanthridin-8-yl)-1-oxopropan-2-yl]amino)-2-oxoethyl)carbamoyl]-1H-pyrrol-2-yl)carbonyl)amino]methaniminium chloride
0.06 mM, 33% inhibition
Arg-Arg-2-naphthylamide
-
above 0.1 mM
benzamidine HCl
-
1.0 mM inhibitor, 29% inhibition, 5.0 mM inhibitor, 61% inhibition
bis-p-nitrophenyl phosphate
-
-
Ca2+
-
0.2 mM, 40% inhibition
Co2+
-
activation up to 50% at 0.001-0.0001 mM, inbhibitory above 0.002 mM
diisopropylfluorophosphate
dimethyl sulfoxide
-
inhibitory effect with more than 5% (v/v) dimethyl sulfoxide
DTNB
-
1.0 mM inhibitor, 54% inhibition, 2.5 mM inhibitor, 87% inhibition
E-64
-
i.e. L-trans-epoxysuccinyl-leucylamido(4-guanidino)butane, 10% inhibition at 0.1 mM
Egg white trypsin inhibitor
-
1.0 mM inhibitor, 34% inhibition
-
EGTA
96% inhibition in the presence of 1 mM EGTA, but 110% activity in the presence of the two inhibitors 1 mM EGTA and 1 mM Zn2+
ethanol
-
the enzyme loses about half of its activity at 5% (v/v) ethanol
Gly-L-Glu
-
36% inhibition at 1 mM
Gly-L-Phe
-
46% inhibition at 1 mM
Gly-L-Phe-L-Leu
-
non-competitive inhibitor, 82% inhibition at 1 mM
iodoacetic acid
-
1.0 mM inhibitor, 25% inhibition, 5.0 mM inhibitor, 48% inhibition
IVYPW
-
hemorphin.like peptide, non-competitive, 50% inhibition at 0.00016 mM
L-Ala-L-Ala-L-Ala
-
4% inhibition at 1 mM
L-Ala-L-Ala-L-Ala-L-Ala
-
58% inhibition at 0.5 mM
L-Arg-L-Phe
-
56% inhibition at 1 mM
L-Arg-L-Phe-L-Ala
-
competitive inhibitor, 99% inhibition at 1 mM
L-Arg-L-Trp
-
46% inhibition at 1 mM
L-Arg-L-Val
-
49% inhibition at 1 mM
L-Asp-L-Ala
-
25% inhibition at 1 mM
L-His-L-Leu
-
76% inhibition at 1 mM
L-His-L-Lys
-
41% inhibition at 1 mM
L-His-L-Phe
-
46% inhibition at 1 mM
L-His-L-Pro
-
16% inhibition at 1 mM
L-Ile-L-His
-
34% inhibition at 1 mM
L-Leu-L-Arg
-
complete inhibition at 0.5 mM
L-Leu-L-Trp
-
competitive inhibitor, 90% inhibition at 1 mM
L-Leu-L-Trp-L-Met
-
competitive inhibitor, 92% inhibition at 1 mM
L-Leu-L-Trp-L-Met-L-Arg-L-Phe-L-Ala
-
competitive inhibitor, complete inhibition at 1 mM
L-Lys-L-Ala
-
23% inhibition at 1 mM
L-Met-L-Arg
-
99% inhibition at 1 mM
L-Phe-L-Ala
-
41% inhibition at 1 mM
L-Phe-L-Arg
-
75% inhibition at 1 mM
L-Phe-L-Leu
-
58% inhibition at 1 mM
L-Phe-L-Met
-
85% inhibition at 1 mM
L-Pro-L-Arg-OH
-
54% inhibition at 1 mM
L-Pro-L-Glu
-
34% inhibition at 1 mM
L-Pro-L-Phe
-
56% inhibition at 1 mM
L-Ser-L-Met
-
32% inhibition at 1 mM
L-Trp-L-Met
-
competitive inhibitor, 94% inhibition at 1 mM
L-Trp-L-Met-L-Asp-L-Phe
-
82% inhibition at 1 mM
L-tryptophyl-L-methionyl-L-alpha-aspartyl-L-phenylalaninamide
-
competitive inhibition
L-Tyr-Gly
-
31% inhibition at 1 mM
L-Tyr-Gly-Gly-L-Phe
-
53% inhibition at 1 mM
L-Tyr-L-Ile
-
72% inhibition at 1 mM
L-tyrosyl-glycine hydroxamic acid
-
L-tyrosyl-L-phenylalanine hydroxamic acid
-
L-Val-L-Tyr
-
competitive inhibitor, 84% inhibition at 1 mM
Leu-enkephalin
-
i.e. L-Tyr-Gly-Gly-L-Phe-L-Leu, 92% inhibition at 1 mM, competitive inhibitor
Leu-Val-Val-Tyr-Pro-Trp-Thr-Gln-Arg
-
Leu-valorphin-Arg
Li+
-
73.0% residual activity at 0.1 mM
Met-enkephalin
-
i.e. L-Tyr-Gly-Gly-L-Phe-L-Met, 61% inhibition at 0.5 mM, competitive inhibitor
methyl N-[5-(carbamimidoylcarbamoyl)-1H-pyrrole-2-carbonyl]-3-[[(pyren-1-yl)methyl]amino]-D-alaninate
0.01 mM, 36% inhibition. Compound is not hydrolysed by enzyme, although the binding affinity is comparable with that of Arg-Arg-2-naphthylamide
N-hydroxy-succinimide
-
1.0 mM inhibitor, 30% inhibition, 5.0 mM inhibitor, 51% inhibition
Nalpha-tosyl-L-Phe-chloromethyl ketone
-
60% inhibition at 0.1 mM
p-aminophenyl mercuric acetate
-
1.0 mM inhibitor, 42% inhibition, 2.5 mM inhibitor, 94% inhibition
p-chloromercuriphenylsulfonic acid
-
-
p-Chlorophenylsulfonate
-
-
p-hydroxymercuriphenyl-sulfonic acid
-
1.0 mM inhibitor, 22% inhibition, 2.5 mM inhibitor, 96% inhibition
p-nitrocatecholsulfate
-
1.0 mM inhibitor, 37% inhibition, 5.0 mM inhibitor, 58% inhibition
Pb(CH3COO)2
-
1.0 mM inhibitor, 53% inhibition, 2.5 mM inhibitor, 97% inhibition
pepstatin
-
1 mM, 43% inhibition
pepstatin A
-
5.0 mM inhibitor, 92% inhibition
Phenylmethanesulfonylfluoride
probestin
-
85% inhibition at 0.1 mM
Propioxanthin A and B
-
-
-
Soybean trypsin inhibitor
-
1.0 mM inhibitor, 64% inhibition, 2.5 mM inhibitor, 76% inhibition
-
TLCK
-
1.0 mM inhibitor, 27% inhibition, 5.0 mM inhibitor, 63% inhibition
TPCK
-
1.0 mM inhibitor, 75% inhibition, 5.0 mM inhibitor, 88% inhibition
Tyr(SO3H)-Gly-Gly-Phe-Leu
-
-
Tyr-Ala-Gly-Phe-Leu
-
Ala2-Leu-enkephalin
Tyr-D-Ala-Gly-Phe-Leu
-
D-Ala2-Leu-enkephalin
Tyr-Gly-Gly-Phe
-
enkephalin fragment
Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile
-
dynorphin A 1-8
Tyr-Pro-Phe-Phe-NH2
-
endomorphin-2
Tyr-Pro-Phe-Val-Glu-Pro-Ile
-
human beta-casomorphin
Tyr-Pro-Trp-Phe-NH2
-
endomorphin-1
Urea
-
sensitive to very low concentrations of urea
Val-Val-Tyr-Pro-Trp-Thr-Gln
-
valorphin
WVYPW
-
hemorphin.like peptide, non-competitive, 50% inhibition at 0.00024 mM
1,10-phenanthroline
-
-
1,10-phenanthroline
Schistosoma sp.
-
-
1,10-phenanthroline
-
2.5 mM, 62% inhibition
2-mercaptoethanol
-
-
3,4-dichloroisocoumarin
-
-
3,4-dichloroisocoumarin
-
-
5,5'-dithiobis(2-nitrobenzoate)
-
-
5,5'-dithiobis(2-nitrobenzoate)
-
reactivation by DTT or 2-mercaptoethanol
5,5'-dithiobis(2-nitrobenzoate)
-
-
5,5'-dithiobis(2-nitrobenzoate)
-
-
5,5'-dithiobis(2-nitrobenzoate)
-
1 mM, 57% inhibition
6-(4,5-dihydro-1H-imidazol-2-yl)-2-[(E)-2-phenylethenyl]-1H-benzimidazole
-
-
6-(4,5-dihydro-1H-imidazol-2-yl)-2-[(E)-2-phenylethenyl]-1H-benzimidazole
0.01 mM, 97.8% inhibition
angiotensin II
-
-
angiotensin III
-
-
Aprotinin
-
1.0 mM inhibitor, 59% inhibition, 5.0 mM inhibitor, 99% inhibition
Arg-Arg
-
-
bestatin
-
10% inhibition at 0.1 mM
bestatin
-
35% inhibition at 0.1 mM
bestatin
-
0.01 mM, 41% inhibition
Cd2+
-
-
Cu2+
-
-
diisopropylfluorophosphate
-
-
diisopropylfluorophosphate
-
-
dithiothreitol
-
-
EDTA
-
-
EDTA
complete loss of activity
EDTA
-
1.0 mM inhibitor, 50% inhibition, 5.0 mM inhibitor, 64% inhibition
EDTA
-
49.2% residual activity at 1 mM
EDTA
-
67% inhibition at 5 mM
EDTA
-
10 mM, 60% inhibition
EDTA
-
1 mM, 19% inhibition
Gly-Gly-Phe-Leu
-
fragment of Leu-enkephalin
Gly-Gly-Phe-Leu
-
enkephalin fragment
Gly-Gly-Phe-Leu
-
fragment of Leu-enkephalin
H-Phe-Gly-NHOH
competitive
H-Phe-Gly-NHOH
competitive
H-Phe-Leu-NHOH
competitive
H-Phe-Leu-NHOH
competitive
H-Phe-Phe-NHOH
competitive
H-Phe-Phe-NHOH
competitive
H-Tyr-Phe-NHOH
competitive
H-Tyr-Phe-NHOH
competitive
Hg2+
-
11.1% residual activity at 0.1 mM
His-Phe-Arg-Trp
-
fragment of alpha-melanocyte-stimulating hormone
His-Phe-Arg-Trp
-
fragment of alpha-melanocyte-stimulating hormone
iodoacetamide
-
1.0 mM inhibitor, 27% inhibition, 5.0 mM inhibitor, 42% inhibition
iodoacetamide
-
0.1 mM, 57% inhibition
K+
-
82.0% residual activity at 0.1 mM
K+
-
0.2 mM, 40% inhibition
Leu-Trp-Met-Arg-Phe
-
-
leupeptin
-
1.0 mM inhibitor, 32% inhibition
leupeptin
-
10% inhibition at 0.1 mM
leupeptin
-
0.1 mM, 71% inhibition
leupeptin
-
0.005 mM, 78% inhibition
Lys-Val-Ile-Leu-Phe
-
fragment of hydra head activator
Lys-Val-Ile-Leu-Phe
-
fragment of hydra head activator
Mg2+
-
0.2 mM, 60% inhibition
Mn2+
-
0.2 mM, 80% inhibition
N-ethylmaleimide
-
1.0 mM inhibitor, 29% inhibition, 2.5 mM inhibitor, 88% inhibition, 5.0 mM inhibitor, 96% inhibition
N-ethylmaleimide
-
complete inhibition at 2 mM
N-ethylmaleimide
-
1 mM, 93% inhibition
Ni2+
-
12.4% residual activity at 0.1 mM
o-phenanthroline
complete loss of activity
o-phenanthroline
-
1.0 mM inhibitor, 46% inhibition, 2.5 mM inhibitor, 85% inhibition, 5.0 mM inhibitor, 96% inhibition
o-phenanthroline
-
93% inhibition at 1 mM
o-phenanthroline
-
1 mM, 70% inhibition
o-phenanthroline
-
50% inhibition at 0.1 mM
p-chloromercuribenzoate
-
-
p-chloromercuribenzoate
-
not with Leu-enkephalin as substrate
p-chloromercuribenzoate
-
-
p-chloromercuribenzoate
-
complete inhibition at 0.001 mM
p-chloromercuribenzoate
-
-
p-chloromercuribenzoate
-
-
p-hydroxymercuribenzoate
-
reactivation by reduced glutathione or mercaptoethanol
p-hydroxymercuribenzoate
-
-
Phenylmethanesulfonylfluoride
-
-
Phenylmethanesulfonylfluoride
-
-
PMSF
-
1.0 mM inhibitor, 53% inhibition, 2.5 mM inhibitor, 87% inhibition
PMSF
-
0.2 mM, 88% inhibition
PMSF
-
40% inhibition at 1 mM
PMSF
-
0.5 mM, 30% inhibition
Proctolin
-
-
puromycin
-
-
puromycin
-
1.0 mM inhibitor, 30% inhibition, 5.0 mM inhibitor, 58% inhibition
puromycin
-
15% inhibition at 0.1 mM
tynorphin
-
-
tynorphin
-
50% inhibition at 0.00062 mM
tynorphin
Val-Val-Tyr-Pro-Trp, 10 microM, 99% inhibition
tynorphin
-
i.e. VVYPW, 50% inhibition at 0.000086 mM, competitive
Tyr-Arg
-
-
Tyr-Gly-Gly-Phe-Leu
-
Leu-enkephalin
Tyr-Gly-Gly-Phe-Leu
-
Leu-enkephalin
Tyr-Gly-Gly-Phe-Met
-
Met-enkephalin
Tyr-Gly-Gly-Phe-Met
-
Met-enkephalin
Tyr-Phe-NHOH
-
Tyr-Tyr
-
-
Zn2+
-
-
Zn2+
-
50.3% residual activity at 1 mM
Zn2+
19% inhibition in the presence of 0.1 mM Zn2+, 99.8% inhibition in the presence of 1 mM Zn2+
Zn2+
-
50% inhibition at 0.032 mM
Zn2+
-
0.2 mM, 80% inhibition
Zn2+
-
50% inhibition at 0.001 mM
Zn2+
10 micromol, strong inhibition
additional information
activities in phosphate buffers are singnificantly lower than in Tris-Hcl buffer
-
additional information
-
activities in phosphate buffers are singnificantly lower than in Tris-Hcl buffer
-
additional information
-
not inhibited by beta-mercaptoethanol
-
additional information
-
structural requirements for inhibition by hemorphin-like peptides
-
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