Crystallization (Comment) | Organism |
---|---|
to 1.6 A resolution, structure of the closed-conformation of ERAP1 with inhibitor Nalpha-(2-[[(1-amino-3-phenylpropyl)(hydroxy)phosphoryl]methyl]pent-4-ynoyl)-D-phenylalaninamide bound in its active site. Inhibitor Nalpha-(2-[[(1-amino-3-phenylpropyl)(hydroxy)phosphoryl]methyl]pent-4-ynoyl)-D-phenylalaninamide is coordinated to the zinc ion via its phosphinic group with a geometry that imitates a transition state analogue | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Nalpha-(2-[[(1-amino-3-phenylpropyl)(hydroxy)phosphoryl]methyl]pent-4-ynoyl)-D-phenylalaninamide | potent phosphinic pseudopeptide inhibitor | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9NZ08 | isoform ERAP1 | - |