Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Cyclohexene oxide | using a post-natal day 4 Fischer 344 rat whole ovary culture system, inhibition of mEH using cyclohexene oxide during 4-vinylcyclohexene exposure results in a greater loss of primordial and small primary follicles relative to 4-vinylcyclohexene-treated ovaries. Also, relative to controls, mEH mRNA is increased on day 4 of 4-vinylcyclohexene exposure, followed by increased mEH protein after 6 days. Inhibition of PI3K signaling increases mEH mRNA and protein expression | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
7,12-dimethylbenz[a]anthracene + 3 H2O | Rattus norvegicus | - |
7,12-dimethylbenz[a]anthracene-3,4-diol-1,2-epoxide | - |
? | |
cis-stilbene oxide + H2O | Rattus norvegicus | - |
(+)-(1R,2R)-1,2-diphenylethane-1,2-diol | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Rattus norvegicus | P07687 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
ovary | - |
Rattus norvegicus | - |
ovary | exposure to 4-vinylcyclohexene results in increased mRNA and protein expression of microsomal epoxide hydrolase, and an inactive tetrol metabolite 4-(1,2-dihydroxy)ethyl-1,2-dihydroxycyclohexane can be formed in mouse ovarian follicles, potentially through detoxification action of mEH | Mus musculus | - |
ovary | using a post-natal day 4 Fischer 344 rat whole ovary culture system, inhibition of mEH using cyclohexene oxide during 4-vinylcyclohexene exposure results in a greater loss of primordial and small primary follicles relative to 4-vinylcyclohexene-treated ovaries. Also, relative to controls, mEH mRNA is increased on day 4 of 4-vinylcyclohexene exposure, followed by increased mEH protein after 6 days. Inhibition of PI3K signaling increases mEH mRNA and protein expression | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-vinylcyclohexene + H2O | - |
Rattus norvegicus | ? | - |
? | |
4-vinylcyclohexene + H2O | - |
Mus musculus | ? | after exposure of ovary to 4-vinylcyclohexene, an inactive tetrol metabolite 4-(1,2-dihydroxy)ethyl-1,2-dihydroxycyclohexane can be formed, potentially through detoxification action of mEH | ? | |
7,12-dimethylbenz[a]anthracene + 3 H2O | - |
Rattus norvegicus | 7,12-dimethylbenz[a]anthracene-3,4-diol-1,2-epoxide | - |
? | |
7,12-dimethylbenz[a]anthracene + 3 H2O | - |
Mus musculus | 7,12-dimethylbenz[a]anthracene-3,4-diol-1,2-epoxide | bioactivation reaction | ? | |
cis-stilbene oxide + H2O | - |
Rattus norvegicus | (+)-(1R,2R)-1,2-diphenylethane-1,2-diol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
mEH | - |
Mus musculus |
mEH | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | enzyme mRNA and protein level do not change until 4 days after 4-vinylcyclohexene diepoxide exposure (0.03 mM) | additional information |
Mus musculus | exposure to 4-vinylcyclohexene results in increased mRNA and protein expression of microsomal epoxide hydrolase | up |
Rattus norvegicus | inhibition of PI3K signaling increases mEH mRNA and protein expression. In a post-natal day 4 Fischer 344 rat whole ovary culture system, mEH mRNA is increased on day 4 of 4-vinylcyclohexene exposure, followed by increased mEH protein after 6 days | up |
Rattus norvegicus | the enzyme's protein level is significantly increased by phosphatidyinositol-3 kinase inhibition by 221% on day 4 and 14% on day 6 relative to control-treated ovaries | up |