D11A |
inactive |
Homo sapiens |
D11N |
mutant with strongly reduced phosphatase activity of sEH (2fold decrease in Km and 9fold decrease in kcat compared to the wild type enzyme), the N-terminal domain has phosphatase activity, the C-terminal domain has epoxide hydrolase activity |
Homo sapiens |
D184A |
the mutation results in a complete loss of the phosphatase activity of sEH, the N-terminal domain has phosphatase activity, the C-terminal domain has epoxide hydrolase activity |
Homo sapiens |
D184N |
the mutation results in a complete loss of the phosphatase activity of sEH, the N-terminal domain has phosphatase activity, the C-terminal domain has epoxide hydrolase activity |
Homo sapiens |
D185A |
the mutation leads to a completely inactive sEH phosphatase, the N-terminal domain has phosphatase activity, the C-terminal domain has epoxide hydrolase activity |
Homo sapiens |
D185A |
the mutation results in a complete loss of the phosphatase activity of sEH, the N-terminal domain has phosphatase activity, the C-terminal domain has epoxide hydrolase activity |
Homo sapiens |
D185N |
the mutation reduces Vmax of the enzyme to 35% while leaving the Km unchanged, the N-terminal domain has phosphatase activity, the C-terminal domain has epoxide hydrolase activity |
Homo sapiens |
D9A |
the mutation results in a complete loss of the phosphatase activity of sEH, the N-terminal domain has phosphatase activity, the C-terminal domain has epoxide hydrolase activity |
Homo sapiens |
D9N |
the mutation results in a complete loss of the phosphatase activity of sEH, the N-terminal domain has phosphatase activity, the C-terminal domain has epoxide hydrolase activity |
Homo sapiens |
K160A |
the mutation results in a complete loss of the phosphatase activity of sEH, the N-terminal domain has phosphatase activity, the C-terminal domain has epoxide hydrolase activity |
Homo sapiens |
K160N |
the mutation results in a complete loss of the phosphatase activity of sEH, the N-terminal domain has phosphatase activity, the C-terminal domain has epoxide hydrolase activity |
Homo sapiens |
K160R |
the mutation results in a complete loss of the phosphatase activity of sEH, the N-terminal domain has phosphatase activity, the C-terminal domain has epoxide hydrolase activity |
Homo sapiens |
N123D |
the mutation results in a complete loss of the phosphatase activity of sEH, the N-terminal domain has phosphatase activity, the C-terminal domain has epoxide hydrolase activity |
Homo sapiens |
N124D |
mutant with strongly reduced phosphatase activity of she, the N-terminal domain has phosphatase activity, the C-terminal domain has epoxide hydrolase activity |
Homo sapiens |
N189A |
the mutation results in a complete loss of the phosphatase activity of sEH, the N-terminal domain has phosphatase activity, the C-terminal domain has epoxide hydrolase activity |
Homo sapiens |
N189D |
the mutation results in a complete loss of the phosphatase activity of sEH, the N-terminal domain has phosphatase activity, the C-terminal domain has epoxide hydrolase activity |
Homo sapiens |
T123A |
mutant with strongly reduced phosphatase activity of she, the N-terminal domain has phosphatase activity, the C-terminal domain has epoxide hydrolase activity |
Homo sapiens |
T123N |
mutant with strongly reduced phosphatase activity of sEH, the N-terminal domain has phosphatase activity, the C-terminal domain has epoxide hydrolase activity |
Homo sapiens |