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Information on EC - soluble epoxide hydrolase

for references in articles please use BRENDA:EC3.3.2.10

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IUBMB Comments

Catalyses the hydrolysis of trans-substituted epoxides, such as trans-stilbene oxide, as well as various aliphatic epoxides derived from fatty-acid metabolism . It is involved in the metabolism of arachidonic epoxides (epoxyicosatrienoic acids; EETs) and linoleic acid epoxides. The EETs, which are endogenous chemical mediators, act at the vascular, renal and cardiac levels to regulate blood pressure [4,5]. The enzyme from mammals is a bifunctional enzyme: the C-terminal domain exhibits epoxide-hydrolase activity and the N-terminal domain has the activity of EC, lipid-phosphate phosphatase [1,2]. Like EC, microsomal epoxide hydrolase, it is probable that the reaction involves the formation of an hydroxyalkyl—enzyme intermediate [4,6]. The enzyme can also use leukotriene A4, the substrate of EC, leukotriene-A4 hydrolase, but it forms 5,6-dihydroxy-7,9,11,14-icosatetraenoic acid rather than leukotriene B4 as the product [9,10]. In vertebrates, five epoxide-hydrolase enzymes have been identified to date: EC (leukotriene-A4 hydrolase), EC (hepoxilin-epoxide hydrolase), EC (microsomal epoxide hydrolase), EC (soluble epoxide hydrolase) and EC (cholesterol 5,6-oxide hydrolase) .

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Reaction Schemes

epoxide hydrolase, soluble epoxide hydrolase, ephx2, cytosolic epoxide hydrolase, epoxide hydrolase 1, epoxide hydrolase 2, ephx3, teso hydrolase, hepoxilin hydrolase, epxh1, more

an epoxide + H2O = a glycol
show the reaction diagram
2-methylpropene degradation, arachidonate metabolites biosynthesis, docosahexaenoate metabolites biosynthesis, icosapentaenoate metabolites biosynthesis, linoleate metabolites biosynthesis, maresin biosynthesis, poly-hydroxy fatty acids biosynthesis