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Information on EC - soluble epoxide hydrolase

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EC Tree
     3 Hydrolases
         3.3 Acting on ether bonds
             3.3.2 Ether hydrolases
       soluble epoxide hydrolase
IUBMB Comments
Catalyses the hydrolysis of trans-substituted epoxides, such as trans-stilbene oxide, as well as various aliphatic epoxides derived from fatty-acid metabolism . It is involved in the metabolism of arachidonic epoxides (epoxyicosatrienoic acids; EETs) and linoleic acid epoxides. The EETs, which are endogenous chemical mediators, act at the vascular, renal and cardiac levels to regulate blood pressure [4,5]. The enzyme from mammals is a bifunctional enzyme: the C-terminal domain exhibits epoxide-hydrolase activity and the N-terminal domain has the activity of EC, lipid-phosphate phosphatase [1,2]. Like EC, microsomal epoxide hydrolase, it is probable that the reaction involves the formation of an hydroxyalkyl---enzyme intermediate [4,6]. The enzyme can also use leukotriene A4, the substrate of EC, leukotriene-A4 hydrolase, but it forms 5,6-dihydroxy-7,9,11,14-icosatetraenoic acid rather than leukotriene B4 as the product [9,10]. In vertebrates, five epoxide-hydrolase enzymes have been identified to date: EC (leukotriene-A4 hydrolase), EC (hepoxilin-epoxide hydrolase), EC (microsomal epoxide hydrolase), EC (soluble epoxide hydrolase) and EC (cholesterol 5,6-oxide hydrolase) .
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The enzyme appears in viruses and cellular organisms
Reaction Schemes
AnEH, BNSEH1, CEH, Cterm-EH, Cytosolic epoxide hydrolase, EC, EC, EET-metabolizing enzyme, EH, EH3, more
an epoxide + H2O = a glycol
show the reaction diagram