Literature summary for 3.3.2.10 extracted from

Kim, I.H.; Tsai, H.J.; Nishi, K.; Kasagami, T.; Morisseau, C.; Hammock, B.D.
1,3-disubstituted ureas functionalized with ether groups are potent inhibitors of the soluble epoxide hydrolase with improved pharmacokinetic properties (2007), J. Med. Chem., 50, 5217-5226.

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Inhibitors

Inhibitors	Comment	Organism	Structure
1-adamantan-1-yl-3-(5-(2-[2-(2,2,2-trifluoroethoxy)ethoxy]-ethoxy)pentyl)urea	-	Homo sapiens
1-adamantan-1-yl-3-(5-(2-[2-(4-ethylphenoxy)ethoxy]-ethoxy)pentyl)urea	-	Homo sapiens
1-adamantan-1-yl-3-(5-butoxypentyl)urea	-	Homo sapiens
1-adamantan-1-yl-3-(5-hexoxypropyl)urea	-	Homo sapiens
1-adamantan-1-yl-3-(5-pentoxybutyl)urea	-	Homo sapiens
1-adamantan-1-yl-3-(5-propyloxyhexyl)urea	-	Homo sapiens
1-adamantan-1-yl-3-(5-[4-propyloxy]butyl)-urea	-	Homo sapiens
1-adamantan-1-yl-3-(5-[4-propyloxy]propyl)-urea	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0000014	-	30°C, pH 7.0	Homo sapiens	1-adamantan-1-yl-3-(5-(2-[2-(2,2,2-trifluoroethoxy)ethoxy]-ethoxy)pentyl)urea
0.0000017	-	30°C, pH 7.0	Homo sapiens	1-adamantan-1-yl-3-(5-(2-[2-(4-ethylphenoxy)ethoxy]-ethoxy)pentyl)urea
0.0000023	-	30°C, pH 7.0	Homo sapiens	1-adamantan-1-yl-3-(5-[4-propyloxy]butyl)-urea
0.0000025	-	30°C, pH 7.0	Homo sapiens	1-adamantan-1-yl-3-(5-[4-propyloxy]propyl)-urea
0.0000037	-	30°C, pH 7.0	Homo sapiens	1-adamantan-1-yl-3-(5-propyloxyhexyl)urea
0.0000041	-	30°C, pH 7.0	Homo sapiens	1-adamantan-1-yl-3-(5-butoxypentyl)urea
0.0000044	-	30°C, pH 7.0	Homo sapiens	1-adamantan-1-yl-3-(5-pentoxybutyl)urea
0.0000056	-	30°C, pH 7.0	Homo sapiens	1-adamantan-1-yl-3-(5-hexoxypropyl)urea

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Release 2023.1 (January 2023)