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Literature summary for 3.2.2.27 extracted from
- Crystal structure of family 4 uracil-DNA glycosylase from Sulfolobus tokodaii and a function of tyrosine 170 in DNA binding (2015), FEBS Lett., 589, 2675-2682 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli | Sulfurisphaera tokodaii |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| free enzyme and in complex with uracil | Sulfurisphaera tokodaii |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| L169A | the mutant retains most of the wild type activity | Sulfurisphaera tokodaii |
| N171A | the mutant retains most of the wild type activity | Sulfurisphaera tokodaii |
| Y170A | inactive | Sulfurisphaera tokodaii |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sulfurisphaera tokodaii | Q96YD0 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Sulfurisphaera tokodaii |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| uracil-containing DNA + H2O | - |
Sulfurisphaera tokodaii | uracil + DNA with abasic site | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| family 4 uracil-DNA glycosylase | - |
Sulfurisphaera tokodaii |
| UDG | - |
Sulfurisphaera tokodaii |
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Release 2023.1 (January 2023)
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