Crystallization (Comment) | Organism |
---|---|
- |
Drosophila melanogaster |
in complex with inhibitors (3R,4R,5R)-3,4-dihydroxy-5-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)pyrrolidin-2-one and (3R,4R,5R)-3,4-dihydroxy-5-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)-1-methylpyrrolidin-2-one, to 1.08 A and 1.74 A resolution, respectively | Drosophila melanogaster |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(1S,2R,8R,8aR)-octahydroindolizine-1,2,8-triol | - |
Drosophila melanogaster | |
(2R,3R,4S)-2-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)pyrrolidine-3,4-diol | - |
Drosophila melanogaster | |
(2S,3R,4S)-2-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)pyrrolidine-3,4-diol | - |
Canavalia ensiformis | |
(2S,3R,4S)-2-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)pyrrolidine-3,4-diol | - |
Drosophila melanogaster | |
(2S,3R,4S)-2-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)pyrrolidine-3,4-diol | - |
Homo sapiens | |
(2S,3R,4S)-2-[([(1R)-2-[(4-bromophenyl)(hydroxy)methoxy]-1-phenylethyl]amino)methyl]pyrrolidine-3,4-diol | - |
Homo sapiens | |
(3R,4R,5R)-3,4-dihydroxy-5-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)-1-methylpyrrolidin-2-one | - |
Drosophila melanogaster | |
(3R,4R,5R)-3,4-dihydroxy-5-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)pyrrolidin-2-one | - |
Drosophila melanogaster | |
(3R,4R,5S)-3,4-dihydroxy-5-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)-1-methylpyrrolidin-2-one | competitive inhibitor | Canavalia ensiformis | |
(3R,4R,5S)-3,4-dihydroxy-5-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)-1-methylpyrrolidin-2-one | competitive inhibitor | Drosophila melanogaster | |
(3R,4R,5S)-3,4-dihydroxy-5-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)-1-methylpyrrolidin-2-one | - |
Homo sapiens | |
(3R,4R,5S)-3,4-dihydroxy-5-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)pyrrolidin-2-one | competitve inhibitor | Canavalia ensiformis | |
(3R,4R,5S)-3,4-dihydroxy-5-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)pyrrolidin-2-one | competitve inhibitor | Drosophila melanogaster | |
(3R,4R,5S)-3,4-dihydroxy-5-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)pyrrolidin-2-one | competitve inhibitor | Homo sapiens | |
(3R,4R,5S)-5-[([(1R)-2-[(4-bromophenyl)(hydroxy)methoxy]-1-phenylethyl]amino)methyl]-3,4-dihydroxy-1-methylpyrrolidin-2-one | - |
Homo sapiens | |
(3R,4R,5S)-5-[([(1R)-2-[(4-bromophenyl)(hydroxy)methoxy]-1-phenylethyl]amino)methyl]-3,4-dihydroxypyrrolidin-2-one | - |
Homo sapiens | |
mannostatin | - |
Homo sapiens | |
swainsonine | competitve inhibitor | Canavalia ensiformis | |
swainsonine | competitve inhibitor | Drosophila melanogaster | |
swainsonine | competitve inhibitor | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.55 | - |
4-methylumbelliferyl-alpha-D-mannopyranoside | extracted from endothelial cells HCEC | Homo sapiens | |
0.65 | - |
4-methylumbelliferyl-alpha-D-mannopyranoside | extracted from human glioblastoma cells LNZ308 | Homo sapiens | |
1.065 | - |
4-methylumbelliferyl-alpha-D-mannopyranoside | extracted from human glioblastoma cells LN18 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
Golgi apparatus | - |
Drosophila melanogaster | 5794 | - |
Golgi apparatus | - |
Homo sapiens | 5794 | - |
Golgi apparatus | - |
Canavalia ensiformis | 5794 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Canavalia ensiformis | - |
- |
- |
Drosophila melanogaster | - |
- |
- |
Drosophila melanogaster | Q24451 | isoform GMII | - |
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Drosophila melanogaster |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endothelial cell line | HCEC | Homo sapiens | - |
glioblastoma cell line | LNZ 308 | Homo sapiens | - |
LN-18 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-methyl-umbelliferyl-alpha-D-mannopyranoside + H2O | 30 min, 37°C | Homo sapiens | 4-methyl-umbelliferone + alpha-D-mannopyranose | - |
? | |
4-methylumbelliferyl alpha-D-mannoside + H2O | - |
Homo sapiens | 4-methylumbelliferone + alpha-D-mannose | - |
? | |
4-nitrophenyl-alpha-D-mannopyranoside + H2O | 30 min, 37°C | Canavalia ensiformis | 4-nitrophenol + alpha-D-mannopyranose | - |
? | |
4-nitrophenyl-alpha-D-mannopyranoside + H2O | 30 min, 20°C | Drosophila melanogaster | 4-nitrophenol + alpha-D-mannose | - |
? |
Synonyms | Comment | Organism |
---|---|---|
alpha-mannosidase II | - |
Drosophila melanogaster |
alpha-mannosidase II | - |
Homo sapiens |
alpha-mannosidase II | - |
Canavalia ensiformis |
dGMII | - |
Drosophila melanogaster |
human type II alpha-mannosidase | - |
Homo sapiens |
jack bean alpha-mannosidase | - |
Canavalia ensiformis |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
20 | - |
- |
Drosophila melanogaster |
37 | - |
- |
Homo sapiens |
37 | - |
- |
Canavalia ensiformis |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00002 | - |
swainsonine | - |
Drosophila melanogaster | |
0.00002 | - |
(1S,2R,8R,8aR)-octahydroindolizine-1,2,8-triol | 20C, pH 6.8 | Drosophila melanogaster | |
0.000135 | - |
(2S,3R,4S)-2-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)pyrrolidine-3,4-diol | - |
Canavalia ensiformis | |
0.000155 | - |
swainsonine | - |
Canavalia ensiformis | |
0.000206 | - |
(3R,4R,5S)-3,4-dihydroxy-5-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)-1-methylpyrrolidin-2-one | - |
Canavalia ensiformis | |
0.00055 | - |
(3R,4R,5S)-3,4-dihydroxy-5-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)-1-methylpyrrolidin-2-one | extracted from human glioblastoma cells LNZ308 | Homo sapiens | |
0.00067 | - |
(3R,4R,5S)-3,4-dihydroxy-5-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)-1-methylpyrrolidin-2-one | extracted from endothelial cells HCEC | Homo sapiens | |
0.001 | - |
(3R,4R,5S)-3,4-dihydroxy-5-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)-1-methylpyrrolidin-2-one | - |
Drosophila melanogaster | |
0.001 | - |
(3R,4R,5R)-3,4-dihydroxy-5-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)-1-methylpyrrolidin-2-one | 20C, pH 6.8 | Drosophila melanogaster | |
0.0032 | - |
(3R,4R,5S)-3,4-dihydroxy-5-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)-1-methylpyrrolidin-2-one | extracted from human glioblastoma cells LN18 | Homo sapiens | |
0.004 | - |
(3R,4R,5S)-3,4-dihydroxy-5-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)pyrrolidin-2-one | - |
Canavalia ensiformis | |
0.022 | - |
(3R,4R,5S)-3,4-dihydroxy-5-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)pyrrolidin-2-one | - |
Drosophila melanogaster | |
0.022 | - |
(3R,4R,5R)-3,4-dihydroxy-5-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)pyrrolidin-2-one | 20C, pH 6.8 | Drosophila melanogaster | |
0.0233 | - |
(2S,3R,4S)-2-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)pyrrolidine-3,4-diol | extracted from endothelial cells HCEC | Homo sapiens | |
0.0325 | - |
(2S,3R,4S)-2-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)pyrrolidine-3,4-diol | extracted from human glioblastoma cells LN18 | Homo sapiens | |
0.0415 | - |
(2S,3R,4S)-2-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)pyrrolidine-3,4-diol | extracted from human glioblastoma cells LNZ308 | Homo sapiens | |
0.067 | - |
(2S,3R,4S)-2-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)pyrrolidine-3,4-diol | - |
Drosophila melanogaster | |
0.067 | - |
(2R,3R,4S)-2-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)pyrrolidine-3,4-diol | 20C, pH 6.8 | Drosophila melanogaster |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00001 | - |
extracted from endothelial cells HCEC | Homo sapiens | swainsonine | |
0.00002 | - |
extracted from human glioblastoma cells LNZ308 | Homo sapiens | swainsonine | |
0.00005 | - |
extracted from human glioblastoma cells LN18 | Homo sapiens | swainsonine | |
0.0005 | - |
extracted from endothelial cells HCEC | Homo sapiens | (3R,4R,5S)-3,4-dihydroxy-5-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)-1-methylpyrrolidin-2-one | |
0.0005 | - |
extracted from human glioblastoma cells LNZ308 | Homo sapiens | (3R,4R,5S)-3,4-dihydroxy-5-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)-1-methylpyrrolidin-2-one | |
0.00075 | - |
extracted from endothelial cells HCEC | Homo sapiens | (3R,4R,5S)-5-[([(1R)-2-[(4-bromophenyl)(hydroxy)methoxy]-1-phenylethyl]amino)methyl]-3,4-dihydroxy-1-methylpyrrolidin-2-one | |
0.002 | - |
extracted from human glioblastoma cells LN18 | Homo sapiens | (3R,4R,5S)-3,4-dihydroxy-5-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)-1-methylpyrrolidin-2-one | |
0.0075 | - |
extracted from human glioblastoma cells LNZ308 | Homo sapiens | (3R,4R,5S)-5-[([(1R)-2-[(4-bromophenyl)(hydroxy)methoxy]-1-phenylethyl]amino)methyl]-3,4-dihydroxy-1-methylpyrrolidin-2-one | |
0.025 | - |
extracted from endothelial cells HCEC | Homo sapiens | (2S,3R,4S)-2-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)pyrrolidine-3,4-diol | |
0.05 | - |
extracted from human glioblastoma cells LN18 | Homo sapiens | (2S,3R,4S)-2-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)pyrrolidine-3,4-diol | |
0.05 | - |
extracted from human glioblastoma cells LNZ308 | Homo sapiens | (2S,3R,4S)-2-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)pyrrolidine-3,4-diol | |
0.05 | - |
extracted from human glioblastoma cells LNZ308 | Homo sapiens | (3R,4R,5S)-3,4-dihydroxy-5-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)pyrrolidin-2-one | |
0.075 | - |
extracted from endothelial cells HCEC | Homo sapiens | (3R,4R,5S)-3,4-dihydroxy-5-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)pyrrolidin-2-one | |
0.075 | - |
extracted from endothelial cells HCEC | Homo sapiens | (2S,3R,4S)-2-[([(1R)-2-[(4-bromophenyl)(hydroxy)methoxy]-1-phenylethyl]amino)methyl]pyrrolidine-3,4-diol | |
0.075 | - |
extracted from endothelial cells HCEC | Homo sapiens | (3R,4R,5S)-5-[([(1R)-2-[(4-bromophenyl)(hydroxy)methoxy]-1-phenylethyl]amino)methyl]-3,4-dihydroxypyrrolidin-2-one | |
0.075 | - |
extracted from human glioblastoma cells LN18 | Homo sapiens | (3R,4R,5S)-5-[([(1R)-2-[(4-bromophenyl)(hydroxy)methoxy]-1-phenylethyl]amino)methyl]-3,4-dihydroxy-1-methylpyrrolidin-2-one | |
0.075 | - |
extracted from human glioblastoma cells LNZ308 | Homo sapiens | (2S,3R,4S)-2-[([(1R)-2-[(4-bromophenyl)(hydroxy)methoxy]-1-phenylethyl]amino)methyl]pyrrolidine-3,4-diol | |
0.15 | - |
extracted from human glioblastoma cells LNZ308 | Homo sapiens | (3R,4R,5S)-5-[([(1R)-2-[(4-bromophenyl)(hydroxy)methoxy]-1-phenylethyl]amino)methyl]-3,4-dihydroxypyrrolidin-2-one | |
0.2 | - |
extracted from human glioblastoma cells LN18 | Homo sapiens | (2S,3R,4S)-2-[([(1R)-2-[(4-bromophenyl)(hydroxy)methoxy]-1-phenylethyl]amino)methyl]pyrrolidine-3,4-diol | |
0.35 | - |
extracted from human glioblastoma cells LN18 | Homo sapiens | (3R,4R,5S)-3,4-dihydroxy-5-([[(1R)-2-hydroxy-1-phenylethyl]amino]methyl)pyrrolidin-2-one | |
0.75 | - |
extracted from human glioblastoma cells LN18 | Homo sapiens | (3R,4R,5S)-5-[([(1R)-2-[(4-bromophenyl)(hydroxy)methoxy]-1-phenylethyl]amino)methyl]-3,4-dihydroxypyrrolidin-2-one |