Literature summary for 3.2.1.113 extracted from

Tu, H.C.; Hsiao, Y.C.; Yang, W.Y.; Tsai, S.L.; Lin, H.K.; Liao, C.Y.; Lu, J.W.; Chou, Y.T.; Wang, H.D.; Yuh, C.H.
Up-regulation of Golgi alpha-mannosidase IA and down-regulation of Golgi alpha-mannosidase IC activates unfolded protein response during hepatocarcinogenesis (2017), Hepatol. Commun., 1, 230-247 .

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
Golgi apparatus	-	Homo sapiens	5794	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P33908	-	-
Homo sapiens	Q9NR34	-	-

Synonyms

Synonyms	Comment	Organism
MAN1A1	-	Homo sapiens
MAN1C1	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	aberrant regulation of alpha-1,2 mannosidases can result in cancer. MAN1C1 plays a role in tumor suppression in hepatocarcinogenesis. Down-regulation of MAN1C activates unfolded protein response during hepatocarcinogenesis	Homo sapiens
malfunction	aberrant regulation of alpha-1,2 mannosidases can result in cancer. Upregulation of MAN1A1 activates unfolded protein response during hepatocarcinogenesis	Homo sapiens
physiological function	key enzyme in N-glycosylation is required for the formation of mature glycoproteins in eukaryotes. MAN1A1 represents an oncogene. Upregulation of MAN1A1 activates unfolded protein response during hepatocarcinogenesis	Homo sapiens
physiological function	key enzymes in N-glycosylation is required for the formation of mature glycoproteins in eukaryotes. MAN1C1 plays a role in tumor suppression in hepatocarcinogenesis. Down-regulation of MAN1C activates unfolded protein response during hepatocarcinogenesis	Homo sapiens

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Release 2023.1 (January 2023)