Cloned (Comment) | Organism |
---|---|
recombinant expression of N-terminally His-tagged enzyme in Drosophila melanogaster S2 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
acarbose | - |
Homo sapiens | |
blintol | selenium analogue of salacinol | Homo sapiens | |
de-O-sulfonated kotalanol | isolated from Salacia reticulata | Homo sapiens | |
kotalanol | isolated from Salacia reticulata | Homo sapiens | |
miglitol | - |
Homo sapiens | |
additional information | inhibition profiles of the individual N- and C-terminal catalytic subunits of the enzyme by clinical glucosidase inhibitors, acarbose and miglitol, and glucosidase inhibitors from an Ayurvedic remedy used for the treatment of type II diabetes, overview | Homo sapiens | |
salacinol | isolated from Salacia reticulata | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P14410 | - |
- |
Purification (Comment) | Organism |
---|---|
recombinant N-terminally His-tagged enzyme from Drosophila melanogaster S2 cells by copper affinity chromatography and ion exchange chromatography | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
small intestine | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme is active with maltose, maltotriose, and sucrose, only the N-terminal catalytic domain acts as alpha-1,6-glucosidase | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
More | the enzyme belongs to the family 31 of glycoside hydrolases | Homo sapiens |
sucrase-isomaltase | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000012 | - |
de-O-sulfonated kotalanol | N-terminal cataklytic domain, pH and temperature not specified in the publication | Homo sapiens | |
0.000148 | - |
miglitol | N-terminal cataklytic domain, pH and temperature not specified in the publication | Homo sapiens | |
0.00016 | - |
blintol | N-terminal cataklytic domain, pH and temperature not specified in the publication | Homo sapiens | |
0.000277 | - |
salacinol | N-terminal cataklytic domain, pH and temperature not specified in the publication | Homo sapiens | |
0.0006 | - |
kotalanol | N-terminal cataklytic domain, pH and temperature not specified in the publication | Homo sapiens | |
0.014 | - |
acarbose | N-terminal cataklytic domain, pH and temperature not specified in the publication | Homo sapiens |