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Literature summary for 3.13.2.1 extracted from

  • Huang, Y.; Wang, S.; Ding, X.; Wu, C.; Chen, J.; Hu, Z.; Du, X.; Wang, G.
    Inhibition of S-adenosyl-L-homocysteine hydrolase alleviates alloimmune response by down-regulating CD4+ T-cell activation in a mouse heart transplantation model (2020), Ann. Transl. Med., 8, 1582 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.13.2.1

Inhibitors

Inhibitors Comment Organism Structure
adenosine dialdehyde irreversible inhibitor Mus musculus
DZ2002 reversible inhibitor Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-homocysteine + H2O Mus musculus
-
 L-homocysteine + adenosine
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P50247
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-homocysteine + H2O
-
 Mus musculus L-homocysteine + adenosine
-
 ?

Synonyms

Synonyms Comment Organism
S-adenosyl-L-homocysteine hydrolase
-
 Mus musculus
SAHH
-
 Mus musculus

General Information

General Information Comment Organism
drug target adenosylhomocysteinase inhibitors are promising complementary therapeutic agents in organ transplantation. Inhibitors (AdOx and DZ2002) alleviate allograft rejection in cardiac transplantation by inhibition of CD4+ T alloimmune response Mus musculus