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Literature summary for 3.13.2.1 extracted from
- Mycobacterium tuberculosis S-adenosyl-l-homocysteine hydrolase is negatively regulated by Ser/Thr phosphorylation (2013), Biochem. Biophys. Res. Commun., 430, 858-864.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli BL21(DE3)Star cells | Mycobacterium tuberculosis |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0185 | - |
S-adenosyl-L-homocysteine | at pH 7.0 and 37°C | Mycobacterium tuberculosis |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 50000 | - |
x * 50000, SDS-PAGE | Mycobacterium tuberculosis |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-homocysteine + H2O | Mycobacterium tuberculosis | - |
L-homocysteine + adenosine | - |
? | |
| S-adenosyl-L-homocysteine + H2O | Mycobacterium tuberculosis H37Rv | - |
L-homocysteine + adenosine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycobacterium tuberculosis | - |
- |
- |
| Mycobacterium tuberculosis H37Rv | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | phosphorylation at Thr2 and Thr221 negatively affects enzymatic activity | Mycobacterium tuberculosis |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| TALON metal affinity resin column chromatography | Mycobacterium tuberculosis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-homocysteine + H2O | - |
Mycobacterium tuberculosis | L-homocysteine + adenosine | - |
? | |
| S-adenosyl-L-homocysteine + H2O | - |
Mycobacterium tuberculosis H37Rv | L-homocysteine + adenosine | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 50000, SDS-PAGE | Mycobacterium tuberculosis |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AHCY | - |
Mycobacterium tuberculosis |
| S-adenosylhomocysteine hydrolase | - |
Mycobacterium tuberculosis |
| SAHH | - |
Mycobacterium tuberculosis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Mycobacterium tuberculosis | |
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Release 2023.1 (January 2023)
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