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Literature summary for 3.13.2.1 extracted from
- S-Adenosylhomocysteine hydrolase from hamster liver: purification and kinetic properties (1983), Arch. Biochem. Biophys., 226, 65-72.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 3-deaza-(+/-)-aristeromycin | - |
Mesocricetus auratus |  |
| 3-deazaadenosine | - |
Mesocricetus auratus | |
| adenine | - |
Mesocricetus auratus | |
| S-adenosyl-L-homocysteine | - |
Mesocricetus auratus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (+/-)-aristeromycin | - |
Mesocricetus auratus | |
| 3-deaza-(+/-)-aristeromycin | - |
Mesocricetus auratus | |
| 3-Deazaadenine | - |
Mesocricetus auratus | |
| 3-deazaadenosine | - |
Mesocricetus auratus | |
| 3-deazaadenosylhomocysteine | - |
Mesocricetus auratus | |
| 3-deazaaristeromycylhomocysteine | - |
Mesocricetus auratus | |
| adenine | - |
Mesocricetus auratus | |
| S-adenosyl-L-homocysteine | - |
Mesocricetus auratus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.001 | - |
S-adenosyl-L-homocysteine | - |
Mesocricetus auratus | |
| 0.001 | - |
adenosine | - |
Mesocricetus auratus | |
| 0.001 | - |
3-deazaadenosine | - |
Mesocricetus auratus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 48000 | - |
4 * 48000, SDS-PAGE | Mesocricetus auratus |
| 200000 | - |
gradient gel electrophoresis | Mesocricetus auratus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-homocysteine + H2O | Mesocricetus auratus | - |
adenosine + L-homocysteine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mesocricetus auratus | - |
Golden Syrian hamster | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| 4666fold to homogeneity | Mesocricetus auratus |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 1.4 | - |
- |
Mesocricetus auratus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-deazaadenosine + L-homocysteine | - |
Mesocricetus auratus | 3-deazaadenosylhomocysteine | - |
? | |
| DL-homocysteine + 3-deazaadenosine | - |
Mesocricetus auratus | ? | - |
? | |
| DL-homocysteine + adenosine | - |
Mesocricetus auratus | S-adenosyl-DL-homocysteine | - |
? | |
| S-adenosyl-L-homocysteine + H2O | - |
Mesocricetus auratus | adenosine + L-homocysteine | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | 4 * 48000, SDS-PAGE | Mesocricetus auratus |
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