BRENDA - Enzyme Database show
show all sequences of 3.1.8.1

A novel thermostable arylesterase from the archaeon Sulfolobus solfataricus P1: purification, characterization, and expression

Park, Y.J.; Yoon, S.J.; Lee, H.B.; J. Bacteriol. 190, 8086-8095 (2008)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
3-[(3-cholamidopropyl)-dimethylammonio]-1-propanesulfonate
the enzyme is activated by 87% by incubation with 1% (w/v) 3-[(3-cholamidopropyl)-dimethylammonio]-1-propanesulfonate, at 30°C
Saccharolobus solfataricus
dimethyl sulfoxide
21% increase of activity at 50% (v/v) dimethyl sulfoxide, at 30°C
Saccharolobus solfataricus
ethanol
15% increase of activity at 50% (v/v) ethanol, at 30°C
Saccharolobus solfataricus
Lubrol
the enzyme is activated by 14% by incubation with 1% Lubrol, at 30°C
Saccharolobus solfataricus
paraoxon
115 increase of activita in the presence of 0.5 mM paraoxon, after 30 min at 30°C
Saccharolobus solfataricus
pyridoxal 5'-phosphate
110% activity in the presence of 5 mM pyridoxal 5'-phosphate, after 30 min at 30°C
Saccharolobus solfataricus
Tween 20
the enzyme is activated by 67% by incubation for 60 min with 1% (v/v) Tween 20 at 30°C
Saccharolobus solfataricus
Cloned(Commentary)
Commentary
Organism
expressed in Escherichia coli BL21(DE3) cells
Saccharolobus solfataricus
Engineering
Amino acid exchange
Commentary
Organism
C105S
mutant shows 24.0% activity compared to the wild type enzyme
Saccharolobus solfataricus
C107S
mutant shows 30.8% activity compared to the wild type enzyme
Saccharolobus solfataricus
C129S
mutant shows 3.6% activity compared to the wild type enzyme
Saccharolobus solfataricus
D251N
mutant shows 0.6% activity compared to the wild type enzyme
Saccharolobus solfataricus
H281N
mutant shows 19.4% activity compared to the wild type enzyme
Saccharolobus solfataricus
S156A
mutant shows 0.012% activity compared to the wild type enzyme
Saccharolobus solfataricus
Inhibitors
Inhibitors
Commentary
Organism
Structure
2-propanol
55% residual activity in the presence of 90% (v/v) 2-propanol, after 60 min at 70°C
Saccharolobus solfataricus
acetonitrile
43% residual activity in the presence of 90% (v/v) acetonitrile, after 60 min at 70°C
Saccharolobus solfataricus
diethyl dicarbonate
6% residual activity in the presence of 5 mM diethyl dicarbonate, after 30 min at 30°C
Saccharolobus solfataricus
diisopropylfluorophosphate
complete inactivation at 5 mM diisopropylfluorophosphate, after 30 min at 30°C
Saccharolobus solfataricus
dimethyl sulfoxide
71% residual activity in the presence of 90% (v/v) dimethyl sulfoxide, after 60 min at 70°C
Saccharolobus solfataricus
EDTA
92% residual activity in the presence of 10 mM EDTA, after 30 min at 75°C
Saccharolobus solfataricus
eserine
92% residual activity in the presence of 5 mM eserine, after 30 min at 30°C
Saccharolobus solfataricus
ethanol
63% residual activity in the presence of 90% (v/v) ethanol, after 60 min at 70°C
Saccharolobus solfataricus
Hg2+
complete inactivation at 5 mM Hg2+, after 30 min at 30°C
Saccharolobus solfataricus
methanol
48% residual activity in the presence of 90% (v/v) methanol, after 60 min at 70°C
Saccharolobus solfataricus
NaCl
76% residual activity in the presence of 2 M NaCl, after 60 min at 70°C
Saccharolobus solfataricus
p-chloromercuribenzoate
23% residual activity in the presence of 5 mM p-chloromercuribenzoate, after 30 min at 30°C
Saccharolobus solfataricus
Phenylglyoxal
97% residual activity in the presence of 5 mM phenylglyoxal, after 30 min at 30°C
Saccharolobus solfataricus
phenylmethylsulfonyl fluoride
23% residual activity in the presence of 5 mM phenylmethylsulfonyl fluoride, after 30 min at 30°C
Saccharolobus solfataricus
SDS
about half of the activity is retained at 1% SDS after incubation for 60 min at 70°C, the addition of 5% SDS completely eliminates the enzyme activity at 70°C
Saccharolobus solfataricus
Triton X-100
11% residual activity in the presence of 5% (v/v) Tween 80, after 60 min at 70°C
Saccharolobus solfataricus
Tween 80
21% residual activity in the presence of 5% (v/v) Tween 80, after 60 min at 70°C
Saccharolobus solfataricus
Urea
88% residual activity in the presence of 8 M urea, after 60 min at 70°C
Saccharolobus solfataricus
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.005
-
paraoxon
recombinant wild type enzyme, in 100 mM sodium phosphate buffer (pH 7.0), at 60°C
Saccharolobus solfataricus
0.246
-
methyl paraoxon
recombinant wild type enzyme, in 100 mM sodium phosphate buffer (pH 7.0), at 60°C
Saccharolobus solfataricus
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
35175
-
1 * 35175, MALDI-TOF mass spectrometry
Saccharolobus solfataricus
35180
-
MALDI-TOF mass spectrometry
Saccharolobus solfataricus
37000
-
SDS-PAGE
Saccharolobus solfataricus
Organic Solvent Stability
Organic Solvent
Commentary
Organism
Triton X-100
after incubation for 60 min with Triton X-100 the enzyme activity is remarkably decreased with increasing temperature and concentration
Saccharolobus solfataricus
urea
the purified enzyme shows high stability against urea
Saccharolobus solfataricus
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Saccharolobus solfataricus
B5BLW5
-
-
Saccharolobus solfataricus P1
B5BLW5
-
-
Purification (Commentary)
Commentary
Organism
recombinant enzyme is purified by DEAE-cellulose column chromatography, butyl-Sepharose column chromatography, Q-Sepharose column chromatography, and hydroxyapatite column chromatography
Saccharolobus solfataricus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
methyl paraoxon + H2O
-
692889
Saccharolobus solfataricus
4-nitrophenol + dimethyl phosphate
-
-
-
?
paraoxon + H2O
paraoxon is the best substrate for the purified arylesterase
692889
Saccharolobus solfataricus
diethylphosphate + 4-nitrophenol
-
-
-
?
Subunits
Subunits
Commentary
Organism
monomer
1 * 35175, MALDI-TOF mass spectrometry
Saccharolobus solfataricus
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
94
-
-
Saccharolobus solfataricus
Temperature Stability [°C]
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
50
94
the enzyme retains 52% of its activity after 50 h of incubation at 90°C, the enzyme is rapidly inactivated above 94°C, most of the enzyme activity is maintained for 5 days at 50°C, the enzyme activity gradually decreases with time at higher temperatures, approximately 70% of the enzyme activity remains after 5 days at 70°C, and 52% of it is still preserved after 50 h at 90°C, however, at 90°C after 5 days, the enzyme is completely inactivated
Saccharolobus solfataricus
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
342
-
methyl paraoxon
recombinant wild type enzyme, in 100 mM sodium phosphate buffer (pH 7.0), at 60°C
Saccharolobus solfataricus
597
-
paraoxon
recombinant wild type enzyme, in 100 mM sodium phosphate buffer (pH 7.0), at 60°C
Saccharolobus solfataricus
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7
-
-
Saccharolobus solfataricus
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
3-[(3-cholamidopropyl)-dimethylammonio]-1-propanesulfonate
the enzyme is activated by 87% by incubation with 1% (w/v) 3-[(3-cholamidopropyl)-dimethylammonio]-1-propanesulfonate, at 30°C
Saccharolobus solfataricus
dimethyl sulfoxide
21% increase of activity at 50% (v/v) dimethyl sulfoxide, at 30°C
Saccharolobus solfataricus
ethanol
15% increase of activity at 50% (v/v) ethanol, at 30°C
Saccharolobus solfataricus
Lubrol
the enzyme is activated by 14% by incubation with 1% Lubrol, at 30°C
Saccharolobus solfataricus
paraoxon
115 increase of activita in the presence of 0.5 mM paraoxon, after 30 min at 30°C
Saccharolobus solfataricus
pyridoxal 5'-phosphate
110% activity in the presence of 5 mM pyridoxal 5'-phosphate, after 30 min at 30°C
Saccharolobus solfataricus
Tween 20
the enzyme is activated by 67% by incubation for 60 min with 1% (v/v) Tween 20 at 30°C
Saccharolobus solfataricus
Cloned(Commentary) (protein specific)
Commentary
Organism
expressed in Escherichia coli BL21(DE3) cells
Saccharolobus solfataricus
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
C105S
mutant shows 24.0% activity compared to the wild type enzyme
Saccharolobus solfataricus
C107S
mutant shows 30.8% activity compared to the wild type enzyme
Saccharolobus solfataricus
C129S
mutant shows 3.6% activity compared to the wild type enzyme
Saccharolobus solfataricus
D251N
mutant shows 0.6% activity compared to the wild type enzyme
Saccharolobus solfataricus
H281N
mutant shows 19.4% activity compared to the wild type enzyme
Saccharolobus solfataricus
S156A
mutant shows 0.012% activity compared to the wild type enzyme
Saccharolobus solfataricus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
2-propanol
55% residual activity in the presence of 90% (v/v) 2-propanol, after 60 min at 70°C
Saccharolobus solfataricus
acetonitrile
43% residual activity in the presence of 90% (v/v) acetonitrile, after 60 min at 70°C
Saccharolobus solfataricus
diethyl dicarbonate
6% residual activity in the presence of 5 mM diethyl dicarbonate, after 30 min at 30°C
Saccharolobus solfataricus
diisopropylfluorophosphate
complete inactivation at 5 mM diisopropylfluorophosphate, after 30 min at 30°C
Saccharolobus solfataricus
dimethyl sulfoxide
71% residual activity in the presence of 90% (v/v) dimethyl sulfoxide, after 60 min at 70°C
Saccharolobus solfataricus
EDTA
92% residual activity in the presence of 10 mM EDTA, after 30 min at 75°C
Saccharolobus solfataricus
eserine
92% residual activity in the presence of 5 mM eserine, after 30 min at 30°C
Saccharolobus solfataricus
ethanol
63% residual activity in the presence of 90% (v/v) ethanol, after 60 min at 70°C
Saccharolobus solfataricus
Hg2+
complete inactivation at 5 mM Hg2+, after 30 min at 30°C
Saccharolobus solfataricus
methanol
48% residual activity in the presence of 90% (v/v) methanol, after 60 min at 70°C
Saccharolobus solfataricus
NaCl
76% residual activity in the presence of 2 M NaCl, after 60 min at 70°C
Saccharolobus solfataricus
p-chloromercuribenzoate
23% residual activity in the presence of 5 mM p-chloromercuribenzoate, after 30 min at 30°C
Saccharolobus solfataricus
Phenylglyoxal
97% residual activity in the presence of 5 mM phenylglyoxal, after 30 min at 30°C
Saccharolobus solfataricus
phenylmethylsulfonyl fluoride
23% residual activity in the presence of 5 mM phenylmethylsulfonyl fluoride, after 30 min at 30°C
Saccharolobus solfataricus
SDS
about half of the activity is retained at 1% SDS after incubation for 60 min at 70°C, the addition of 5% SDS completely eliminates the enzyme activity at 70°C
Saccharolobus solfataricus
Triton X-100
11% residual activity in the presence of 5% (v/v) Tween 80, after 60 min at 70°C
Saccharolobus solfataricus
Tween 80
21% residual activity in the presence of 5% (v/v) Tween 80, after 60 min at 70°C
Saccharolobus solfataricus
Urea
88% residual activity in the presence of 8 M urea, after 60 min at 70°C
Saccharolobus solfataricus
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.005
-
paraoxon
recombinant wild type enzyme, in 100 mM sodium phosphate buffer (pH 7.0), at 60°C
Saccharolobus solfataricus
0.246
-
methyl paraoxon
recombinant wild type enzyme, in 100 mM sodium phosphate buffer (pH 7.0), at 60°C
Saccharolobus solfataricus
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
35175
-
1 * 35175, MALDI-TOF mass spectrometry
Saccharolobus solfataricus
35180
-
MALDI-TOF mass spectrometry
Saccharolobus solfataricus
37000
-
SDS-PAGE
Saccharolobus solfataricus
Organic Solvent Stability (protein specific)
Organic Solvent
Commentary
Organism
Triton X-100
after incubation for 60 min with Triton X-100 the enzyme activity is remarkably decreased with increasing temperature and concentration
Saccharolobus solfataricus
urea
the purified enzyme shows high stability against urea
Saccharolobus solfataricus
Purification (Commentary) (protein specific)
Commentary
Organism
recombinant enzyme is purified by DEAE-cellulose column chromatography, butyl-Sepharose column chromatography, Q-Sepharose column chromatography, and hydroxyapatite column chromatography
Saccharolobus solfataricus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
methyl paraoxon + H2O
-
692889
Saccharolobus solfataricus
4-nitrophenol + dimethyl phosphate
-
-
-
?
paraoxon + H2O
paraoxon is the best substrate for the purified arylesterase
692889
Saccharolobus solfataricus
diethylphosphate + 4-nitrophenol
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
monomer
1 * 35175, MALDI-TOF mass spectrometry
Saccharolobus solfataricus
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
94
-
-
Saccharolobus solfataricus
Temperature Stability [°C] (protein specific)
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
50
94
the enzyme retains 52% of its activity after 50 h of incubation at 90°C, the enzyme is rapidly inactivated above 94°C, most of the enzyme activity is maintained for 5 days at 50°C, the enzyme activity gradually decreases with time at higher temperatures, approximately 70% of the enzyme activity remains after 5 days at 70°C, and 52% of it is still preserved after 50 h at 90°C, however, at 90°C after 5 days, the enzyme is completely inactivated
Saccharolobus solfataricus
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
342
-
methyl paraoxon
recombinant wild type enzyme, in 100 mM sodium phosphate buffer (pH 7.0), at 60°C
Saccharolobus solfataricus
597
-
paraoxon
recombinant wild type enzyme, in 100 mM sodium phosphate buffer (pH 7.0), at 60°C
Saccharolobus solfataricus
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7
-
-
Saccharolobus solfataricus
Other publictions for EC 3.1.8.1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
749829
Zhang
The crystal structure of the ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618, Mycobacterium tuberculosis H37Rv
Biochem. Biophys. Res. Commun.
510
224-229
2019
-
-
1
1
-
-
-
1
-
2
-
3
-
7
-
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1
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-
-
-
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3
2
1
-
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1
-
-
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1
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1
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1
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3
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1
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3
2
1
-
-
-
1
-
-
-
-
2
2
-
-
-
749938
Bigley
Transition State Analysis of ...
Sphingobium sp. TCM1
Biochemistry
58
1246-1259
2019
-
-
-
-
-
-
-
27
-
1
-
-
-
2
-
-
-
1
-
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29
-
1
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-
26
1
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-
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27
-
1
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29
-
1
-
-
26
1
-
-
-
-
-
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26
26
750549
Gudla
Organophosphate hydrolase int ...
Sphingobium fuliginis
FEBS Lett.
593
581-593
2019
-
-
1
-
5
-
-
-
1
2
-
2
-
3
-
-
1
-
-
2
-
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3
1
-
-
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-
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1
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5
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1
2
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2
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1
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2
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3
1
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3
3
-
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749640
Haque
-
Cloning of an organophosphoru ...
Lactobacillus sakei, Lactobacillus sakei WCP904
Appl. Biol. Chem.
61
643-651
2018
-
-
1
-
-
-
-
-
-
-
-
13
-
2
-
-
1
-
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-
1
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15
2
1
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1
-
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-
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1
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-
-
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-
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13
-
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1
-
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1
-
15
2
1
-
-
-
1
-
-
-
-
1
1
-
-
-
749924
Bigley
Multiple reaction products fr ...
Sphingobium sp. TCM1
Biochemistry
57
1842-1846
2018
-
-
-
-
-
-
-
14
-
1
-
1
-
2
-
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17
-
1
-
-
14
1
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14
-
1
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1
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17
-
1
-
-
14
1
-
-
-
-
-
-
-
14
14
750194
Restaino
High yield production and pur ...
Saccharolobus solfataricus, Sulfolobus acidocaldarius
BMC Biotechnol.
18
18
2018
-
2
2
-
3
-
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-
-
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2
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2
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2
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5
-
2
2
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2
2
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2
2
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3
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2
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2
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5
-
2
2
-
-
2
2
-
-
-
1
1
-
-
-
750428
Bizon
The effect of divalent metal ...
Homo sapiens
Environ. Toxicol. Pharmacol.
58
77-83
2018
-
-
-
-
-
-
3
-
-
1
-
-
-
3
-
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-
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1
-
1
1
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-
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3
-
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1
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1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
750511
Perla-Kajan
Paraoxonase 1 Q192R genotype ...
Homo sapiens
FASEB J.
32
6019
2018
-
-
-
-
1
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-
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-
-
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1
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1
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1
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1
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1
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1
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751626
Zhang
Theoretical studies on cataly ...
Oryctolagus cuniculus
Molecules
23
0000
2018
-
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1
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3
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1
2
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1
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1
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1
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1
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2
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1
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3
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1
2
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1
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1
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2
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3
3
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-
-
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Homo sapiens
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Transcriptional regulation of ...
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Alteration of paraoxonase, ar ...
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Expression and purification o ...
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Expression of recombinant org ...
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An efficient thermostable org ...
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Invitro evaluation of the cat ...
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Zsiros
Paraoxonase-1 arylesterase ac ...
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Zargari
The common variant Q192R at t ...
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750558
Santillan
New and highly active microbi ...
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Farnoosh
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Aggarwal
Toward understanding the cata ...
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Chambers
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Abulimite
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Bigley
Variants of phosphotriesteras ...
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Zuo
Engineering Pseudomonas putid ...
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Biodegradation
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Le
Rational design of paraoxonas ...
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Cebi
The activities of serum parao ...
Homo sapiens
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1
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752094
Bajaj
Expression and purification o ...
Homo sapiens
Protein Expr. Purif.
115
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2015
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1
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1
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752173
Korkmaz
Paraoxonase and arylesterase ...
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Scand. J. Clin. Lab. Invest.
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259-264
2015
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1
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729013
Erzengin
Purification and characterizat ...
Bos taurus
Appl. Biochem. Biotechnol.
173
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2014
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1
3
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1
1
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729075
Sirotkina
Rhodococcus lactonase with org ...
Rhodococcus erythropolis, Rhodococcus erythropolis AC-1514D, Rhodococcus ruber, Rhodococcus ruber AC-1513D
Appl. Microbiol. Biotechnol.
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2647-2656
2014
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729147
Jeong
Rational design of organophosp ...
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Biochem. Biophys. Res. Commun.
449
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2014
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8
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2
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2
2
729324
Bajaj
Interplay between amino acid r ...
Homo sapiens
Biochimie
105
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2014
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1
1
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4
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4
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1
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1
1
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4
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1
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4
4
729353
Dedeoglu
Purification of Holstein bull ...
Bos taurus
Biol. Trace Elem. Res.
158
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1
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1
1
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5
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5
5
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1
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1
1
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1
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1
1
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1
1
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729510
Bzdrenga
SacPox from the thermoacidophi ...
Sulfolobus acidocaldarius, Sulfolobus acidocaldarius DSM 639
BMC Res. Notes
7
333
2014
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3
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3
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3
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1
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1
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3
3
729582
Kim
Enhanced activity and stabilit ...
Brevundimonas diminuta
Chem. Commun. (Camb. )
50
5345-5348
2014
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730097
Kallnik
Characterization of a phosphot ...
Vulcanisaeta moutnovskia
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2014
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5
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6
1
1
1
3
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730115
Kirbas
Paraoxonase and arylesterase a ...
Homo sapiens
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2014
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1
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730173
Kati
Serum paraoxonase and aryleste ...
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17-21
2014
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1
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731001
Jackson
Use of OpdA, an organophosphor ...
Agrobacterium tumefaciens
Toxicology
317
1-5
2014
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1
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724723
Porzio
Mn2+ modulates the kinetic pro ...
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Chem. Biol. Interact.
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2013
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3
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2
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2
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1
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2
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1
1
3
2
2
2
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2
2
728912
Gotthard
Crystallization and preliminar ...
Pseudomonas pseudoalcaligenes
Acta Crystallogr. Sect. F
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73-76
2013
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729541
Kartkaya
Investigation of the possible ...
Rattus norvegicus
Cell Biochem. Funct.
31
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2013
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730114
Kirbas
Serum paraoxonase and aryleste ...
Homo sapiens
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1106-1109
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730898
Bajaj
Characterization of human para ...
Homo sapiens
Protein Sci.
22
1799-1807
2013
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730929
Olama
Evaluation of paraoxonase and ...
Homo sapiens
Rheumatol. Int.
33
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2013
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Sayin
Effects of some metals on para ...
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2012
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Arslan
In vitro efficacy of some catt ...
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726306
Hiblot
Structural and enzymatic chara ...
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PLoS One
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726484
Hiblot
Characterisation of the organo ...
Saccharolobus solfataricus, Saccharolobus solfataricus P2
Sci. Rep.
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Erzengin
In vitro inhibition effect of ...
Homo sapiens
Appl. Biochem. Biotechnol.
168
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2012
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730208
Ben-David
Catalytic versatility and back ...
synthetic construct
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418
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730265
Muthukrishnan
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synthetic construct
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730945
Tekin Koruk
The activity of paraoxonase an ...
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Scand. J. Clin. Lab. Invest.
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513-517
2012
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709584
Fairchild
Computational characterization ...
Homo sapiens
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1
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3
-
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1
-
-
-
-
-
-
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-
-
-
714002
Harisa
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L-arginine ameliorates arylest ...
Rattus norvegicus
Asian J. Biochem.
6
263-272
2011
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1
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2
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1
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2
-
-
1
-
-
-
-
-
-
-
-
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1
-
-
1
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-
714112
Valiyaveettil
Protective efficacy of catalyt ...
Homo sapiens, Oryctolagus cuniculus
Biochem. Pharmacol.
81
800-809
2011
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2
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2
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2
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2
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6
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2
-
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2
-
2
-
-
6
-
-
-
-
-
-
-
-
-
-
-
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-
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714759
Moghtaderi
Serum paraoxonase and aryleste ...
Homo sapiens
Clin. Biochem.
44
288-292
2011
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1
-
-
-
-
-
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2
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2
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1
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1
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-
2
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
714893
Hashemi
Serum paraoxonase and aryleste ...
Homo sapiens
Eur. J. Endocrinol.
164
219-222
2011
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1
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-
-
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1
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1
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1
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1
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1
-
-
1
-
-
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1
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1
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715735
Bayrak
Differential hydrolysis of hom ...
Homo sapiens
J. Chromatogr. B
879
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2011
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2
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2
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1
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2
4
-
1
1
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2
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1
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-
1
-
2
4
-
1
1
-
-
-
-
-
-
-
-
-
-
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-
2
2
715738
Duygu
Serum paraoxonase and aryleste ...
Homo sapiens
J. Clin. Lab. Anal.
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311-316
2011
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-
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3
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2
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1
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2
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-
1
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
716956
Valiyaveettil
In vitro efficacy of paraoxona ...
Homo sapiens, Oryctolagus cuniculus
Toxicol. In Vitro
25
905-913
2011
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1
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-
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3
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2
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2
-
-
2
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-
2
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7
2
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3
-
-
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1
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-
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-
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3
-
2
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-
2
-
2
-
-
7
2
-
-
-
3
-
-
-
-
-
-
-
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3
3
716957
Trovaslet-Leroy
Organophosphate hydrolases as ...
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Toxicol. Lett.
206
14-23
2011
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1
1
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1
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1
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4
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2
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-
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8
-
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3
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1
1
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-
1
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1
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2
-
-
-
-
8
-
-
-
3
-
-
-
-
-
-
-
-
-
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-
723853
Gotthard
Crystallization and preliminar ...
Sulfolobus islandicus, Sulfolobus islandicus M.16.4
Acta Crystallogr. Sect. F
67
354-357
2011
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1
1
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5
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1
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-
-
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-
-
-
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-
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-
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-
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1
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1
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-
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-
1
-
-
-
-
-
-
-
-
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693321
Pasca
Paraoxonase 1 activities and p ...
Homo sapiens
J. Cell. Mol. Med.
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2010
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1
1
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1
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-
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-
1
-
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-
-
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-
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-
1
1
-
1
-
-
-
-
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-
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-
-
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707214
Samra
Synthesis of cholesterol-conju ...
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Appl. Biochem. Biotechnol.
162
671-686
2010
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-
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-
-
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20
1
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1
1
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2
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-
1
-
-
2
2
1
1
1
1
-
1
-
1
-
1
-
-
1
-
-
-
-
-
-
-
-
-
20
-
1
-
1
1
-
-
-
-
1
-
2
2
1
1
1
1
-
1
-
1
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1
1
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708094
Ashani
Stereo-specific synthesis of a ...
synthetic construct
Chem. Biol. Interact.
187
362-369
2010
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1
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2
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1
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1
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1
4
-
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-
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8
-
-
-
-
-
-
-
-
1
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
4
-
-
-
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8
-
-
-
-
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8
8
708095
Otto
Purification and characterizat ...
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Chem. Biol. Interact.
187
388-392
2010
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1
1
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-
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2
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3
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3
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1
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1
5
1
-
-
-
2
-
-
-
-
-
-
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-
1
1
-
-
-
-
-
-
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2
-
-
3
-
-
-
-
1
-
-
-
1
5
1
-
-
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2
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1
1
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4
4
709264
Renault
Integrative analytical approac ...
Homo sapiens, synthetic construct
J. Chromatogr. B
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1346-1355
2010
3
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1
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1
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2
2
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-
-
-
-
-
-
-
-
-
-
-
3
-
1
-
1
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-
-
1
-
-
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2
-
-
-
-
-
1
-
1
-
2
2
-
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3
3
713690
Cole
The toxicity of mixtures of sp ...
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660
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1
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3
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-
1
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1
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3
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-
-
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-
-
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-
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2
2
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714045
Valiyaveettil
Efficient hydrolysis of the ch ...
Homo sapiens, Oryctolagus cuniculus
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403
97-102
2010
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2
1
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2
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4
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2
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6
-
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8
2
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-
-
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
2
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-
-
-
-
-
-
-
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2
-
6
-
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8
2
-
-
-
-
-
-
-
-
-
2
2
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714216
Tsai
Stereoselective hydrolysis of ...
Homo sapiens
Biochemistry
49
7978-7987
2010
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1
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10
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1
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1
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1
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20
1
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58
-
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-
-
-
-
-
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1
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-
10
-
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-
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1
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1
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20
1
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-
58
-
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55
714895
Cayir
-
Serum paraoxonase and aryleste ...
Homo sapiens
Eur. J. Gen. Med.
7
398-403
2010
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1
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1
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-
-
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-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
1
-
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1
-
-
-
-
-
-
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2
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2
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715315
Schofield
Generation of a mutagenized or ...
Flavobacterium sp., Flavobacterium sp. ATCC 27551
J. Appl. Microbiol.
109
548-557
2010
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1
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8
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1
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22
-
14
1
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-
-
10
-
-
-
-
-
-
-
-
-
1
-
-
8
-
-
-
-
10
-
-
1
-
-
-
-
1
-
-
22
-
14
1
-
-
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10
-
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10
10
715744
Kockar
Differential effects of some a ...
Homo sapiens
J. Enzyme Inhib. Med. Chem.
25
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2010
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1
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1
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
716817
Lu
Catalytic biomaterials: Engine ...
Flavobacterium sp., Flavobacterium sp. ATCC 27 551
Protein Eng. Des. Sel.
23
559-566
2010
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1
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1
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2
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1
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1
-
8
1
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-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
1
-
8
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
724003
Ng
Characterization of a phosphot ...
Saccharolobus solfataricus, Saccharolobus solfataricus P2
Appl. Environ. Microbiol.
77
1181-1186
2010
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1
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-
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1
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1
1
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11
3
-
1
-
-
-
-
-
2
1
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
1
1
-
-
3
-
1
-
-
-
-
2
1
-
-
-
1
-
-
-
-
-
-
-
-
1
1
724576
Merone
Improving the promiscuous nerv ...
Saccharolobus solfataricus, Saccharolobus solfataricus P2
Bioresour. Technol.
101
9204-9212
2010
1
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1
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7
1
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6
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8
-
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-
-
-
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4
1
1
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6
1
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-
-
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1
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1
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-
7
1
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-
-
6
-
-
-
-
-
-
-
-
-
-
-
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4
1
1
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6
1
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8
8
724867
Mandrich
Hyperthermophilic phosphotries ...
Saccharolobus solfataricus, Sulfolobus acidocaldarius
Environ. Technol.
31
1115-1127
2010
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2
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6
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-
-
-
-
-
-
-
-
-
-
-
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2
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
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-
-
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-
-
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-
-
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690419
Kanamori-Kataoka
Paraoxonase activity against n ...
Homo sapiens
Anal. Biochem.
385
94-100
2009
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1
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7
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1
1
-
-
2
-
1
1
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4
4
1
7
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
7
-
1
1
-
-
-
1
1
-
4
4
1
7
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
690676
Efrat
Di-oleoyl phosphatidylcholine ...
Mus musculus
Atherosclerosis
202
461-469
2009
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1
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1
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1
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1
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1
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1
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1
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691852
Barim
Ghrelin, paraoxonase and aryle ...
Homo sapiens
Clin. Biochem.
42
1076-1081
2009
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-
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1
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1
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1
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1
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1
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-
-
-
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-
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-
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-
-
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-
-
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1
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1
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-
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1
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1
-
-
-
-
-
-
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-
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-
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691855
Kasprzak
Arylesterase and paraoxonase a ...
Homo sapiens
Clin. Biochem.
42
50-56
2009
-
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-
-
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1
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1
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1
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1
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2
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1
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-
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-
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692541
Camuzcuoglu
Serum paraoxonase and aryleste ...
Homo sapiens
Gynecol. Oncol.
112
481-485
2009
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1
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1
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1
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5
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693357
Aksoy
Serum lipid profile, oxidative ...
Homo sapiens
J. Clin. Lab. Anal.
23
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2009
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
695051
Hu
In silico analyses of substrat ...
Homo sapiens
Proteins
75
486-498
2009
-
-
1
-
9
-
-
1
-
1
-
1
-
2
-
1
-
-
-
3
-
-
2
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
9
-
-
-
-
1
-
1
-
1
-
-
1
-
-
3
-
-
2
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
695193
Richter
Paraoxonase 1 (PON1) status an ...
Homo sapiens
Toxicol. Appl. Pharmacol.
235
1-9
2009
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
702421
Nguyen
Oxidative inactivation of lact ...
Homo sapiens
Biochim. Biophys. Acta
1790
155-160
2009
-
-
-
-
-
-
5
-
-
1
1
-
-
1
-
-
1
-
-
1
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
1
1
-
-
-
-
1
-
1
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
707155
Popa
Anti-inflammatory therapy with ...
Homo sapiens
Ann. Rheum. Dis.
68
868-872
2009
1
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
707276
Hawwa
Structural basis for thermosta ...
Geobacillus stearothermophilus 10, Geobacillus stearothermophilus
Arch. Biochem. Biophys.
488
109-120
2009
1
-
1
1
-
-
-
3
-
1
1
-
-
5
-
-
1
-
-
-
-
1
6
1
-
-
1
3
-
-
-
-
-
-
-
1
-
1
-
1
-
-
-
-
-
3
-
1
1
-
-
-
-
1
-
-
-
1
6
1
-
-
1
3
-
-
-
-
-
-
-
-
3
3
709262
Gencer
Purification human PON1Q192 an ...
Homo sapiens
J. Chromatogr. B
877
134-140
2009
-
-
-
-
-
-
7
2
-
1
1
-
-
1
-
-
1
-
-
1
4
1
1
1
-
-
-
-
-
-
-
-
-
-
12
-
-
-
-
-
-
-
12
7
-
2
-
1
1
-
-
-
-
1
-
1
4
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
709291
Ekinci
Effect of some analgesics on p ...
Homo sapiens
J. Enzyme Inhib. Med. Chem.
24
1034-1039
2009
-
-
-
-
-
-
6
-
-
1
-
-
-
2
-
-
1
-
-
2
1
-
1
-
-
-
-
-
-
-
-
-
6
-
6
-
-
-
-
-
-
-
6
6
6
-
-
1
-
-
-
-
-
1
-
2
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
709292
Carletti
Update on biochemical properti ...
Brevundimonas diminuta
J. Enzyme Inhib. Med. Chem.
24
1045-1055
2009
2
1
1
-
3
-
3
5
-
3
2
-
-
2
-
-
1
-
-
-
-
-
2
1
-
-
-
5
-
-
-
-
6
-
1
2
1
1
-
-
3
-
1
3
6
5
-
3
2
-
-
-
-
1
-
-
-
-
2
1
-
-
-
5
-
-
-
-
-
-
-
-
5
5
709755
Camuzcuoglu
Decreased paraoxonase and aryl ...
Homo sapiens
J. Womens Health (Larchmt)
18
1435-1439
2009
-
-
-
-
-
-
-
-
-
1
-
-
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
719426
Del Vecchio
Structural determinants of the ...
Saccharolobus solfataricus, Saccharolobus solfataricus P2
Extremophiles
13
461-470
2009
-
-
-
-
-
-
-
-
-
-
-
-
1
10
-
-
-
-
1
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
677893
Aslan
Serum paraoxonase-1 activity i ...
Homo sapiens
Atherosclerosis
196
270-274
2008
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
679262
Can Demirdoegen
Paraoxonase/arylesterase ratio ...
Homo sapiens
Clin. Biochem.
41
1-9
2008
-
-
-
-
2
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
681465
Jackson
In crystallo capture of a Mich ...
Agrobacterium tumefaciens
J. Mol. Biol.
375
1189-1196
2008
-
-
-
1
-
-
-
1
-
3
-
-
-
2
-
-
-
1
-
-
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
3
-
-
-
-
-
-
-
-
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
690390
Farid
Decreased serum paraoxonase-1 ...
Rattus norvegicus
Am. J. Trop. Med. Hyg.
78
770-776
2008
-
-
-
-
-
-
1
-
-
-
-
-
-
5
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
690495
Abd-Allah
Nitrite-mediated inactivation ...
Homo sapiens
Appl. Biochem. Biotechnol.
150
281-288
2008
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
690957
Blum
Inhibitory potency against hum ...
Homo sapiens
Biochemistry
47
5216-5224
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
1
-
-
7
-
-
30
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
7
-
-
30
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
691845
Kotur-Stevuljevic
PON1 status is influenced by o ...
Homo sapiens
Clin. Biochem.
41
1067-1073
2008
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
691848
Alici
Intravenous anesthetics inhibi ...
Homo sapiens
Clin. Biochem.
41
1384-1390
2008
-
-
-
-
-
-
3
-
-
-
1
-
-
2
-
-
1
-
-
2
-
-
1
1
-
-
-
-
-
-
-
-
3
-
3
-
-
-
-
-
-
-
3
3
3
-
-
-
1
-
-
-
-
1
-
2
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
691849
Schulpis
Maternal chronic hepatitis B v ...
Homo sapiens
Clin. Biochem.
41
282-287
2008
-
-
-
-
2
-
-
-
-
-
-
-
-
3
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
691850
Yildiz
Paraoxonase and arylesterase a ...
Homo sapiens
Clin. Biochem.
41
779-784
2008
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
691863
Garces
High-density lipoprotein chole ...
Homo sapiens
Clin. Chem. Lab. Med.
46
809-813
2008
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
691868
Kotani
Reduced paraoxonase 1/aryleste ...
Homo sapiens
Clin. Chim. Acta
395
184-185
2008
-
1
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
691995
van den Berg
Paraoxonase 1 phenotype distri ...
Homo sapiens
Diabet. Med.
25
186-193
2008
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
692441
Marsillach
Immunohistochemical analysis o ...
Mus musculus
Free Radic. Biol. Med.
45
146-157
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
28
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
28
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
692445
Liu
Comparison of the ability of p ...
Homo sapiens
Free Radic. Biol. Med.
45
743-748
2008
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
692574
Parker-Katiraee
Dynamic variation in allele-sp ...
Mus musculus
Hum. Mol. Genet.
17
3263-3270
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
692732
Rock
Consumption of wonderful varie ...
Homo sapiens
J. Agric. Food Chem.
56
8704-8713
2008
1
-
-
-
-
1
1
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
692889
Park
A novel thermostable arylester ...
Saccharolobus solfataricus, Saccharolobus solfataricus P1
J. Bacteriol.
190
8086-8095
2008
7
-
1
-
6
-
18
2
-
-
3
-
2
2
-
-
1
-
-
-
-
-
2
1
1
-
1
2
1
-
-
-
-
-
-
7
-
1
-
-
6
-
-
18
-
2
-
-
3
-
2
-
-
1
-
-
-
-
2
1
1
-
1
2
1
-
-
-
-
-
-
-
-
-
693354
Stoltz
Drosophila are protected from ...
Homo sapiens
J. Clin. Invest.
118
3123-3131
2008
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
693517
Jaichander
Induction of paraoxonase 1 and ...
Homo sapiens, Mus musculus
J. Lipid Res.
49
2142-2148
2008
4
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
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693606
Chungjatupornchai
Biodegradation of organophosph ...
Flavobacterium sp.
J. Microbiol. Biotechnol.
18
946-951
2008
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1
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4
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1
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693642
Elias
Structural basis for natural l ...
Saccharolobus solfataricus
J. Mol. Biol.
379
1017-1028
2008
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1
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3
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3
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1
1
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-
694369
Wills
Paraoxonase 1 (PON1) organopho ...
Homo sapiens
Neurology
70
929-934
2008
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1
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1
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2
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694871
Stevens
Engineered recombinant human p ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
105
12780-12784
2008
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1
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3
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1
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2
1
3
-
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694950
Reeves
Balancing the stability and th ...
Brevundimonas diminuta
Protein Eng. Des. Sel.
21
405-412
2008
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1
1
4
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10
-
2
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1
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1
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5
1
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10
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1
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1
4
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10
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2
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1
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5
1
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10
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-
697248
Hsu
Evaluation of organophosphorus ...
Escherichia coli, Homo sapiens
Chem. Biodivers.
5
1401-1411
2008
-
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1
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7
-
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1
2
1
1
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2
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1
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1
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23
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1
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1
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7
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1
2
1
1
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1
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1
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23
-
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1
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-
677378
Elias
Crystallization and preliminar ...
Saccharolobus solfataricus, Saccharolobus solfataricus MT-4 / DSM 5833
Acta Crystallogr. Sect. F
63
553-555
2007
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1
1
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23
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1
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1
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2
-
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-
677515
Walker
Photonic crystal sensor for or ...
Homo sapiens
Anal. Bioanal. Chem.
389
2115-2124
2007
-
1
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1
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1
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1
-
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1
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-
-
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-
-
-
-
677570
Saruhan
Age-related paraoxonase activi ...
Homo sapiens
Ann. N. Y. Acad. Sci.
1100
218-222
2007
-
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1
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1
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1
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1
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1
1
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3
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1
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1
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1
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1
1
-
3
-
-
-
-
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-
-
-
-
-
-
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-
677884
Muacevic-Katanec
Clinical study on the effect o ...
Homo sapiens
Arzneimittelforschung
57
647-653
2007
1
-
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-
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1
1
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1
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2
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2
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2
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1
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1
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1
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1
1
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1
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2
-
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2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
677892
Santanam
Aspirin is a substrate for par ...
Homo sapiens
Atherosclerosis
191
272-275
2007
-
-
-
-
-
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2
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1
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1
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1
-
1
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-
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1
-
-
-
-
-
-
-
-
-
678109
Rochu
Stabilization of the active fo ...
Homo sapiens
Biochem. Soc. Trans.
35
1616-1620
2007
-
1
1
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-
1
-
-
1
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1
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1
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1
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1
2
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1
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1
1
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1
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1
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1
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1
-
1
2
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
678464
Rochu
Stability of highly purified h ...
Homo sapiens
Biochim. Biophys. Acta
1774
874-883
2007
-
-
-
-
-
-
-
-
-
-
-
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1
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1
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1
1
1
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2
-
1
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-
1
-
-
1
1
1
-
2
-
1
-
-
-
-
-
-
-
-
-
679182
Sirivarasai
Paraoxonase (PON1) polymorphis ...
Homo sapiens
Chem. Biol. Interact.
168
184-192
2007
-
-
1
-
2
-
-
-
-
1
-
1
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2
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1
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2
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1
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1
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1
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2
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1
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1
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1
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
679293
Schulpis
The effect of diet on paraoxon ...
Homo sapiens
Clin. Endocrinol. (Oxf.)
67
687-692
2007
-
-
-
-
-
-
-
-
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1
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1
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1
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1
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1
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
679306
Isik
Paraoxonase and arylesterase l ...
Homo sapiens
Clin. Rheumatol.
26
342-348
2007
-
-
-
-
-
-
-
-
-
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1
-
1
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1
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2
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1
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1
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1
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
679634
Schulpis
Serum paraoxonase/arylesterase ...
Homo sapiens
Eur. J. Clin. Nutr.
61
803-808
2007
-
-
-
-
-
-
-
-
-
-
-
-
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2
-
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1
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1
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1
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1
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
679759
Yeung
Direct detection of stereospec ...
Homo sapiens
FEBS J.
274
1183-1191
2007
-
1
-
-
-
-
-
1
-
1
-
-
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2
-
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-
-
3
-
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4
1
1
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1
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1
-
-
-
-
-
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1
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1
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-
-
3
-
-
4
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
681264
Gaidukov
The development of human sera ...
Homo sapiens
J. Lipid Res.
48
1637-1646
2007
-
-
-
-
-
-
-
-
-
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1
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2
-
-
-
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-
1
1
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2
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1
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1
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
724478
Porzio
A new phosphotriesterase from ...
Sulfolobus acidocaldarius, Sulfolobus acidocaldarius DSM 639
Biochimie
89
625-636
2007
-
-
1
-
-
-
-
1
-
1
3
-
-
8
-
-
1
-
-
-
-
-
8
1
1
1
4
1
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
1
3
-
-
-
-
1
-
-
-
-
8
1
1
1
4
1
1
1
-
-
-
-
-
-
2
2
664153
Sinan
Amphenicol and macrolide deriv ...
Homo sapiens
Biochemistry (Moscow)
71
46-50
2006
-
-
-
-
-
-
2
2
1
-
1
-
-
2
-
-
1
-
-
4
1
-
3
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
2
1
-
1
-
-
-
-
1
-
4
1
-
3
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
665745
Khersonsky
The histidine 115-histidine 13 ...
Homo sapiens
J. Biol. Chem.
281
7649-7656
2006
-
-
-
-
8
-
-
4
1
1
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
7
1
-
-
-
-
-
-
-
-
-
-
-
8
-
-
-
-
4
1
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
7
1
-
-
-
-
-
-
-
-
-
665987
Briseno-Roa
Analogues with fluorescent lea ...
Brevundimonas diminuta, Homo sapiens
J. Med. Chem.
49
246-255
2006
-
-
-
-
-
-
-
2
1
-
-
1
-
3
-
-
-
-
-
1
2
-
22
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
1
-
-
1
-
-
-
-
-
1
2
-
22
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
666809
Cho
Functional analysis of organop ...
Escherichia coli, Escherichia coli K-12, Escherichia coli K-12 XL1-Blue
Protein Eng. Des. Sel.
19
99-105
2006
-
-
2
-
17
-
-
3
-
2
-
-
-
3
-
-
1
-
-
-
1
-
15
-
2
-
-
2
2
-
-
-
-
-
-
-
-
2
-
-
17
-
-
-
-
3
-
2
-
-
-
-
-
1
-
-
1
-
15
-
2
-
-
2
2
-
-
-
-
-
-
-
-
-
669966
Thomas-Moya
Effects of caloric restriction ...
Rattus norvegicus
J. Nutr. Biochem.
17
197-203
2006
-
2
-
-
-
-
-
-
-
-
-
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3
-
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-
2
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-
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-
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2
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-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
670110
Pasca
High levels of homocysteine an ...
Homo sapiens
Life Sci.
78
2244-2248
2006
-
1
-
-
-
-
-
-
-
-
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2
-
-
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-
-
2
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-
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-
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-
1
-
-
-
-
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-
-
-
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-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
677297
Sumegova
Activity of paraoxonase 1 (PON ...
Homo sapiens
Acta Biochim. Pol.
53
783-787
2006
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
677411
Juretic
Paraoxonase/arylesterase in se ...
Homo sapiens
Acta Pharm.
56
59-68
2006
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
677718
Efremenko
Purification of His6-organopho ...
Brevundimonas diminuta
Appl. Microbiol. Biotechnol.
70
558-563
2006
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
678032
Jackson
Anomalous scattering analysis ...
Agrobacterium tumefaciens
Biochem. J.
397
501-508
2006
-
-
1
1
-
-
-
2
-
4
-
-
-
3
-
-
1
1
-
-
2
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
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1
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1
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-
-
678354
Votchitseva
Properties of hexahistidine-ta ...
Brevundimonas diminuta, Brevundimonas diminuta VKM B-1297
Biochemistry (Moscow)
71
167-172
2006
-
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1
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7
-
6
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3
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1
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6
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2
1
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1
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2
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1
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7
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6
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6
-
2
1
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2
1
-
2
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-
678376
Nguyen
Preferable stimulation of PON1 ...
Homo sapiens
Biochim. Biophys. Acta
1758
499-508
2006
4
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5
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1
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1
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1
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-
678489
Sinan
Novel purification strategy fo ...
Homo sapiens
Biochimie
88
565-574
2006
-
-
-
-
-
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2
1
1
1
1
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3
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1
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5
1
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1
1
1
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1
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3
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3
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3
2
3
1
1
1
1
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1
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5
1
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1
1
1
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1
-
-
-
-
-
-
-
-
-
679074
Forrest
-
Activity and lifetime of organ ...
Homo sapiens
Catal. Today
120
30-34
2006
-
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1
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1
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1
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679530
Catano
Distribution of paraoxonase-1 ...
Homo sapiens
Environ. Mol. Mutagen.
47
699-706
2006
-
-
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1
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1
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680347
Blum
Binding of a designed substrat ...
Loligo vulgaris
J. Am. Chem. Soc.
128
12750-12757
2006
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-
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4
-
1
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1
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2
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1
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1
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3
-
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681055
Renault
Tandem purification of two HDL ...
Homo sapiens
J. Chromatogr. B
836
15-21
2006
-
-
-
-
-
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1
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1
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1
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1
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1
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1
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2
-
1
-
-
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1
-
-
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-
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-
-
-
-
681730
Park
Differential effect of lysopho ...
Homo sapiens
Lipids
41
371-380
2006
1
-
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-
5
1
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1
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1
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1
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1
1
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1
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2
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1
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1
1
-
-
-
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-
-
-
-
-
682648
Chu
Expression of organophosphorus ...
Pseudomonas pseudoalcaligenes, Pseudomonas pseudoalcaligenes C2-1
Protein Expr. Purif.
49
9-14
2006
-
-
1
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4
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3
1
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5
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1
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1
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1
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1
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2
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1
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4
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3
1
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1
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-
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1
1
1
1
1
-
1
1
2
-
-
-
-
-
-
-
682846
Votchitseva
-
Insertion of an unnatural amin ...
Brevundimonas diminuta
Russ. Chem. Bull.
55
369-374
2006
1
-
1
-
1
1
-
3
-
-
-
-
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1
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1
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2
1
2
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4
2
2
2
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2
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1
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1
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1
1
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3
-
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1
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-
-
-
2
1
2
-
4
2
2
2
-
2
-
-
-
-
-
-
683351
Huang
Aminopeptidase P mediated deto ...
Escherichia coli
Chembiochem
7
506-514
2006
-
-
-
-
5
-
-
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1
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1
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8
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5
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8
-
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-
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-
-
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-
663774
Grimsley
Structural and mutational stud ...
Brevundimonas diminuta
Arch. Biochem. Biophys.
442
169-179
2005
-
1
1
1
1
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1
3
-
1
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1
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1
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1
1
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1
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2
1
1
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2
1
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2
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1
1
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1
1
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1
2
3
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1
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1
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1
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1
-
2
1
1
-
-
2
1
-
-
-
-
-
-
-
-
-
664064
Gaidukov
High affinity, stability, and ...
Homo sapiens
Biochemistry
44
11843-11854
2005
1
-
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-
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2
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1
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-
1
-
-
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-
3
-
-
-
-
-
-
-
-
-
-
664111
Khersonsky
Structure-reactivity studies o ...
Homo sapiens
Biochemistry
44
6371-6382
2005
-
-
-
-
-
-
-
15
-
-
-
-
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3
-
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-
16
-
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-
32
-
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-
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-
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-
15
-
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-
16
-
-
-
-
32
-
-
-
-
-
-
-
-
-
-
664439
Lei
Improved degradation of organo ...
Pseudomonas putida, Pseudomonas putida JS444
Biotechnol. Prog.
21
678-681
2005
-
-
-
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1
-
-
-
-
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2
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6
-
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1
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10
-
1
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1
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1
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2
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-
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1
-
-
10
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
664630
Costa
Measurement of paraoxonase (PO ...
Homo sapiens
Clin. Chim. Acta
352
37-47
2005
-
1
-
-
1
-
-
-
1
-
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1
-
1
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2
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3
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-
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1
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1
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1
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1
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2
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
664885
Yeung
Analysis of active-site amino- ...
Homo sapiens
FEBS J.
272
2225-2230
2005
-
-
-
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3
-
2
4
-
-
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4
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3
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1
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4
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3
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4
4
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3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
665960
Draganov
Human paraoxonases (PON1, PON2 ...
Homo sapiens
J. Lipid Res.
46
1239-1247
2005
-
-
1
-
-
-
-
-
-
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5
-
-
2
-
1
1
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-
1
4
2
5
1
1
-
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-
1
-
-
-
-
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2
-
-
-
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5
-
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2
2
-
1
4
2
5
2
2
-
-
-
2
-
-
-
-
-
-
-
-
-
666183
Miyamoto
Bovine paraoxonase 1 activitie ...
Bos taurus
J. Vet. Med. Sci.
67
243-248
2005
-
-
-
-
-
-
-
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1
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1
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1
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1
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1
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1
1
1
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-
1
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-
-
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-
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-
-
1
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1
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-
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1
-
1
-
-
1
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
666526
Jackson
The effects of substrate orien ...
Agrobacterium tumefaciens
Org. Biomol. Chem.
3
4343-4350
2005
-
2
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
1
-
-
-
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6
-
-
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-
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-
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2
-
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1
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-
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-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
666808
Roodveldt
Directed evolution of phosphot ...
Brevundimonas diminuta
Protein Eng. Des. Sel.
18
51-58
2005
-
-
1
-
-
-
-
1
-
-
1
-
-
3
-
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1
-
-
1
-
-
1
1
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-
-
5
-
-
-
-
-
-
-
-
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1
-
-
-
-
-
-
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1
-
-
1
-
-
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1
-
1
-
-
1
1
-
-
-
6
-
-
-
-
-
-
-
-
-
-
667551
Kiderlen
Formation and disposition of d ...
Homo sapiens
Biochem. Pharmacol.
69
1853-1867
2005
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
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1
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-
-
-
-
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-
-
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-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667552
Costa
Modulation of paraoxonase (PON ...
Homo sapiens
Biochem. Pharmacol.
69
541-550
2005
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
671006
Kilic
Serum arylesterase and paraoxo ...
Homo sapiens
World J. Gastroenterol.
11
7351-7354
2005
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
3
-
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1
-
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-
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-
-
-
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-
-
1
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
679723
Merone
A thermostable phosphotriester ...
Saccharolobus solfataricus, Saccharolobus solfataricus MT-4 / DSM 5833
Extremophiles
9
297-305
2005
-
-
1
-
-
-
3
3
-
3
3
-
-
24
-
-
1
-
-
-
2
-
6
1
1
1
3
2
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
3
-
3
-
3
3
-
-
-
-
1
-
-
2
-
6
1
1
1
3
2
1
1
-
-
-
-
-
-
-
-
663614
Soukharev
A fluorogenic substrate for de ...
Homo sapiens
Anal. Biochem.
327
140-148
2004
-
-
1
-
-
-
-
3
-
2
-
-
-
2
-
-
-
-
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
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-
-
3
-
2
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
663698
Cho
Altering the substrate specifi ...
Escherichia coli K-12, Escherichia coli K-12 XL1-Blue
Appl. Environ. Microbiol.
70
4681-4685
2004
-
-
1
-
7
-
-
7
-
1
-
-
-
2
-
-
1
-
-
-
6
-
13
-
1
-
-
8
1
-
-
-
-
-
-
-
-
1
-
-
7
-
-
-
-
7
-
1
-
-
-
-
-
1
-
-
6
-
13
-
1
-
-
8
1
-
-
-
-
-
-
-
-
-
663804
Herkenhoff
Effect of organophosphorus hyd ...
Brevundimonas diminuta
Arch. Toxicol.
78
338-343
2004
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
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-
-
-
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-
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-
-
-
-
-
-
-
-
-
-
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-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
664037
Aubert
Mechanism for the hydrolysis o ...
Brevundimonas diminuta
Biochemistry
43
5707-5715
2004
-
-
1
-
7
-
-
13
-
2
-
-
-
2
-
-
1
1
-
-
-
-
4
-
1
-
-
12
1
1
-
-
-
-
-
-
-
1
-
-
7
-
-
-
-
13
-
2
-
-
-
-
-
1
-
-
-
-
4
-
1
-
-
12
1
1
-
-
-
-
-
-
-
-
664184
Yeung
Structure/function analyses of ...
Homo sapiens
Biochim. Biophys. Acta
1702
67-77
2004
-
-
1
-
22
-
-
7
1
1
-
-
-
4
-
-
1
1
-
3
-
-
2
1
1
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
43
-
-
-
-
7
1
1
-
-
-
-
-
2
-
3
-
-
2
1
1
-
-
-
2
-
-
-
-
-
-
-
-
-
664620
Bergmeier
Distribution spectrum of parao ...
Homo sapiens
Clin. Chem.
50
2309-2315
2004
-
-
1
-
1
-
-
-
1
1
-
1
-
1
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
1
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
664771
Liu
-
Purification and characterizat ...
Purpureocillium lilacinum, Purpureocillium lilacinum BP303
Enzyme Microb. Technol.
34
297-303
2004
6
-
-
-
-
-
7
8
1
-
1
-
-
2
-
-
1
-
-
-
2
-
14
1
1
1
4
7
1
1
-
-
-
1
-
6
-
-
-
-
-
-
-
7
-
8
1
-
1
-
-
-
-
1
-
-
2
-
14
1
1
1
4
7
1
1
-
1
-
-
-
-
-
-
665027
James
The importance of high-density ...
Homo sapiens, Mus musculus
Free Radic. Biol. Med.
37
1986-1994
2004
-
-
1
-
1
1
-
-
2
-
-
2
-
2
-
-
1
-
-
4
-
-
4
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
1
-
-
-
-
2
-
-
2
-
-
-
1
-
4
-
-
4
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
666426
Harel
Structure and evolution of the ...
Homo sapiens
Nat. Struct. Mol. Biol.
11
412-419
2004
-
-
1
1
-
-
-
1
1
1
-
1
-
3
-
-
1
1
-
4
-
-
2
1
-
-
-
-
1
1
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
1
1
1
-
1
-
-
-
1
-
4
-
-
2
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
666714
Aharoni
Directed evolution of mammalia ...
Homo sapiens, Mus musculus, Oryctolagus cuniculus
Proc. Natl. Acad. Sci. USA
101
482-487
2004
-
-
1
-
-
-
-
14
-
-
-
-
-
4
-
-
1
-
-
-
-
-
12
-
-
-
-
22
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
14
-
-
-
-
-
-
-
2
-
-
-
-
12
-
-
-
-
22
-
-
-
-
-
-
-
-
-
-
666813
Fu
Expression, purification, and ...
Plesiomonas sp., Plesiomonas sp. M6
Protein Expr. Purif.
36
170-176
2004
-
-
1
-
-
-
-
-
-
-
2
-
-
6
-
1
1
-
-
-
1
-
2
2
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
1
1
-
-
1
-
2
2
1
-
-
-
1
-
-
-
-
-
-
-
-
-
646529
Serhatlioglu
Levels of paraoxonase and aryl ...
Homo sapiens
Cell Biochem. Funct.
21
371-375
2003
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
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-
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-
-
-
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-
1
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-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
646531
Ahmed
Paraoxonase-1 reduces monocyte ...
Homo sapiens
Cardiovasc. Res.
57
225-231
2003
-
1
-
-
-
-
-
-
-
-
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1
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1
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1
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1
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1
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-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646539
Costa
Polymorphisms of paraoxonase ( ...
Homo sapiens
J. Toxicol. Clin. Toxicol.
41
37-45
2003
-
1
-
-
-
-
-
-
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1
-
1
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-
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-
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1
1
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-
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1
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-
-
-
-
-
-
-
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-
1
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-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
649767
Rodrigo
Identification of paraoxonase ...
Rattus norvegicus
Biochem. J.
376
261-268
2003
-
-
-
-
-
-
-
-
1
-
1
-
-
6
-
-
1
-
-
2
-
1
1
1
1
-
2
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
1
-
2
-
1
1
1
1
-
2
-
1
-
1
-
-
-
-
-
-
-
646518
Cho
Bacterial cell surface display ...
Escherichia coli
Appl. Environ. Microbiol.
68
2026-2030
2002
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
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-
1
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-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646520
Josse
Oligomeric states of the deter ...
Homo sapiens
J. Biol. Chem.
277
33386-33397
2002
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646522
Deakin
Enzymatically active paraoxona ...
Homo sapiens
J. Biol. Chem.
277
4301-4308
2002
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646532
Ahmed
Multiple substrates for paraox ...
Homo sapiens
Biochem. Biophys. Res. Commun.
290
391-396
2002
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
678836
Walker
Metabolic engineering of Pseud ...
Pseudomonas putida, Pseudomonas putida KT 2442
Biotechnol. Bioeng.
78
715-721
2002
-
-
1
-
1
-
-
-
-
-
-
-
-
13
-
-
-
-
-
1
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646517
Efremenko
-
Organophosphate hydrolase - an ...
Brevundimonas diminuta, Flavobacterium sp., Rattus norvegicus
Russ. Chem. Bull. (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya)
50
1826-1832
2001
-
-
-
-
-
-
-
2
-
4
-
-
-
3
-
-
-
2
-
-
-
-
17
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
4
-
-
-
-
-
-
-
-
-
-
17
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646524
Ng
Paraoxonase-2 is a ubiquitousl ...
Homo sapiens
J. Biol. Chem.
276
44444-44449
2001
-
-
1
-
-
-
-
-
1
-
1
2
-
1
-
-
-
-
-
3
-
-
2
1
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
1
2
-
-
-
-
-
3
-
-
2
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
646528
La Du
Serum paraoxonase (PON1) isozy ...
Homo sapiens
Drug Metab. Dispos.
29
566-569
2001
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646533
Leviev
Decreased stability of the M54 ...
Homo sapiens
J. Lipid Res.
42
528-535
2001
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646540
Devorshak
Purification and characterizat ...
Platynota idaeusalis
J. Biochem. Mol. Toxicol.
15
55-65
2001
1
-
-
-
-
-
4
-
-
3
1
-
-
1
-
-
1
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
4
-
-
-
3
1
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
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646541
Li
Stereoselective detoxification ...
Brevundimonas diminuta
Bioorg. Med. Chem.
9
2083-2091
2001
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1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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652704
Brushia
Baculovirus-mediated expressio ...
Homo sapiens
J. Lipid Res.
42
951-958
2001
3
-
1
-
-
-
-
2
-
-
1
-
-
2
-
1
1
-
-
1
-
1
2
1
-
-
-
-
-
-
-
-
-
-
-
3
-
1
-
-
-
-
-
-
-
2
-
-
1
-
-
-
1
1
-
1
-
1
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646523
Benning
The binding of substrate analo ...
Brevundimonas diminuta
J. Biol. Chem.
275
30556-30560
2000
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1
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-
1
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2
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-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
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646542
Mulbry
Characterization of a novel or ...
Pimelobacter simplex
Microbiol. Res.
154
285-288
2000
-
-
-
-
-
-
-
2
1
-
1
-
-
5
-
-
-
-
1
-
1
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
1
-
1
-
-
-
-
-
1
-
1
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
650953
Billecke
Human serum paraoxonase (PON1) ...
Homo sapiens
Drug Metab. Dispos.
28
1335-1342
2000
-
-
-
-
1
-
-
2
-
-
-
-
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2
-
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1
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
1
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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646521
Rodrigo
Identification of two rat live ...
Rattus norvegicus
Chem. Biol. Interact.
119-120
263-275
1999
-
-
-
-
-
-
6
2
1
1
1
-
-
1
-
-
1
-
-
1
-
-
1
1
1
-
-
-
1
-
-
-
-
-
10
-
-
-
-
-
-
-
10
6
-
2
1
1
1
-
-
-
-
1
-
1
-
-
1
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
646526
Costa
The role of paraoxonase (PON1) ...
Homo sapiens
Chem. Biol. Interact.
119-120
429-438
1999
-
-
-
-
-
-
-
-
-
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1
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8
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-
-
-
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1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646537
Doorn
Evidence that several conserve ...
Homo sapiens
Chem. Biol. Interact.
119-120
235-241
1999
-
-
-
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3
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1
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-
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-
-
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1
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-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
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35205
Gonzalo
Human liver paraoxonase (PON1) ...
Homo sapiens
J. Biochem. Mol. Toxicol.
12
61-69
1998
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1
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5
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1
-
-
-
2
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
1
1
-
-
-
-
-
1
-
5
-
-
1
-
-
-
2
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1
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35208
Aviram
Paraoxonase inhibits high-dens ...
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101
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1998
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1
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1
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-
2
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1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
1
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-
1
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1
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2
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1
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1
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35217
Pond
Purification of two rat hepati ...
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J. Pharmacol. Exp. Ther.
286
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1998
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1
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646544
Kuo
Calcium binding by human and r ...
Homo sapiens, Oryctolagus cuniculus
Drug Metab. Dispos.
26
653-660
1998
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35216
Nishio
Cigarette smoke extract inhibi ...
Homo sapiens
Biochem. Biophys. Res. Commun.
236
289-293
1997
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1
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1
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Rodrigo
Purification and characterizat ...
Rattus norvegicus
Biochem. J.
321
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1997
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1
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1
1
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1
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2
1
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1
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35207
Reiner
Catalytic properties and distr ...
Homo sapiens
Toxicol. Lett.
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1995
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646525
Sorenson
Reconsideration of the catalyt ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
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1995
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646527
Kuo
Comparison of purified human a ...
Homo sapiens, Oryctolagus cuniculus
Drug Metab. Dispos.
23
935-944
1995
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646534
Banzon
Mechanism-based inactivation o ...
Brevundimonas diminuta
Biochemistry
34
743-749
1995
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5
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5
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35214
Huang
Solubilization and purificatio ...
Mus musculus
Biochem. Pharmacol.
48
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1994
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1
1
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3
1
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Lai
Bimetallic binding motifs in o ...
Escherichia coli
J. Biol. Chem.
269
16579-16584
1994
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1
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1
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646508
Gil
Differences in the kinetic pro ...
Rattus norvegicus
Biochem. Pharmacol.
48
1559-1568
1994
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1
9
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1
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1
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1
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9
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1
1
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4
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1
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1
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1
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35209
Gil
Rat liver paraoxonase: subcell ...
Rattus norvegicus
Chem. Biol. Interact.
87
149-154
1993
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10
1
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1
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1
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1
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10
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1
1
1
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1
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3
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1
1
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1
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1
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35210
Hernandez
Characterization of paraoxonas ...
Homo sapiens
Chem. Biol. Interact.
87
173-177
1993
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2
2
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1
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1
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2
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1
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1
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1
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2
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2
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1
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2
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1
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1
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1
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35218
Tanaka-Kawai
Molecular weight and substrate ...
Homo sapiens
Clin. Chim. Acta
215
127-138
1993
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2
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1
1
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2
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1
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1
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1
1
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646503
Dave
Characterization of organophos ...
Flavobacterium sp.
Chem. Biol. Interact.
87
55-68
1993
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3
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4
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4
-
-
-
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646509
La Du
Studies on human serum paraoxo ...
Homo sapiens
Chem. Biol. Interact.
87
25-34
1993
7
-
-
-
-
-
2
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1
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1
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1
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1
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7
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2
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1
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1
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1
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-
-
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646510
Gil
Partial purification of paraox ...
Rattus norvegicus
Chem. Biol. Interact.
87
69-75
1993
-
-
-
-
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-
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1
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1
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1
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1
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1
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-
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-
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1
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1
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1
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-
1
-
-
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-
-
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-
-
-
-
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35215
Haagen
A new automated method for phe ...
Homo sapiens
Eur. J. Clin. Chem. Clin. Biochem.
30
391-395
1992
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1
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1
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1
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1
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1
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1
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1
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-
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-
1
-
-
1
-
1
-
-
-
1
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-
-
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-
-
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35212
Gan
Purification of human serum pa ...
Homo sapiens
Drug Metab. Dispos.
19
100-106
1991
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-
-
-
-
-
1
2
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1
1
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1
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1
1
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1
2
-
1
1
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
2
-
1
1
-
-
-
1
1
-
1
2
-
1
1
1
-
-
-
1
-
-
1
-
-
-
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-
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35213
Smolen
Characteristics of the genetic ...
Homo sapiens
Drug Metab. Dispos.
19
107-112
1991
-
-
-
-
-
-
-
2
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1
1
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1
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1
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1
1
1
-
-
2
1
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
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1
1
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-
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1
-
-
1
1
1
-
-
2
1
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-
-
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35219
Furlong
Purification of rabbit and hum ...
Homo sapiens, Oryctolagus cuniculus
Biochemistry
30
10133-10140
1991
-
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-
-
-
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1
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4
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2
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2
4
1
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4
-
-
-
-
-
-
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-
-
-
-
-
-
-
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1
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-
-
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2
2
4
1
-
4
-
-
-
-
-
-
-
-
-
-
-
-
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646504
Mackness
Substrate specificity of human ...
Homo sapiens
Biochem. Soc. Trans.
19
304S
1991
-
-
-
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-
-
-
-
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2
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1
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2
1
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4
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
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-
-
-
-
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1
-
2
1
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646507
Hassett
Characterization of cDNA clone ...
Homo sapiens, Oryctolagus cuniculus
Biochemistry
30
10141-10149
1991
-
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2
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-
-
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4
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2
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4
-
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2
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2
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-
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-
-
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2
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4
-
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2
-
-
-
-
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-
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646513
Pellin
Distribution and some biochemi ...
Homo sapiens, Rattus norvegicus
Neurotoxicol. Teratol.
12
611-614
1990
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4
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1
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1
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4
-
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-
-
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1
-
1
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-
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-
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646516
Dumas
Inactivation of organophosphor ...
Brevundimonas diminuta
Arch. Biochem. Biophys.
277
155-159
1990
-
-
-
-
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1
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5
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4
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1
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5
-
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4
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646515
Little
Partial characterization of an ...
Rattus norvegicus
Biochem. Pharmacol.
38
23-29
1989
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1
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1
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4
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1
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1
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4
-
-
-
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35192
Mackness
Multiple forms of sheep serum ...
Ovis aries
Biochem. J.
250
539-545
1988
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-
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1
1
1
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1
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1
1
1
4
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
646500
Mackness
Distinction between A-esterase ...
Bos taurus, Felis catus, Homo sapiens, Hydrochoerus hydrochaeris, Meles taxus, Mus musculus, no activity in aves, Rattus norvegicus, Sus scrofa
Biochem. J.
245
293-296
1987
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8
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10
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8
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10
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-
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